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Practicality of Tetragonal Nano-Zirconia as a Prospective Sorbent in the Preparation of 99Mo/99mTc Generator for Biomedical Applications

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Abstract

The feasibility of using tetragonal nano-zirconia (t-ZrO2) as an effective sorbent for developing a 99Mo/99mTc chromatographic generator was demonstrated. The structural characteristics of the sorbent matrix were investigated by different analytical techniques such as XRD, BET surface area analysis, FT-IR, TEM etc. The material synthesized was nanocrystalline, in tetragonal phase with an average particle size of ~7 nm and a large surface area of 340 m2 g−1. The equilibrium sorption capacity of t-ZrO2 is >250 mg Mo g−1. The present study indicates that 99Mo is both strongly and selectively retained by t-ZrO2 at acidic pH and 99mTc could be readily eluted from it, using 0.9% NaCl solution. A 9.25 GBq (250 mCi) t-ZrO2 based chromatographic 99Mo/99mTc generator was developed and its performance was repeatedly evaluated for 10 days. 99mTc could be eluted with >85% yield having acceptable radionuclidic, radiochemical and chemical purity for clinical applications. The compatibility of the product in the preparation of 99mTc labeled formulations such as 99mTc-EC and 99mTc-DMSA was evaluated and found to be satisfactory.

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Acknowledgements

The authors are grateful to Prof. V. Venugopal, Director, Radiochemistry and Isotope Group, BARC for his valuable suggestions during the course of the work.

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Authors and Affiliations

  1. Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India

    Rubel Chakravarty, Ramu Ram, Ashutosh Dash & Meera Venkatesh

  2. Chemistry Division, Bhabha Atomic Research Centre, Mumbai, India

    Rakesh Shukla & Avesh Kumar Tyagi

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  1. Rubel Chakravarty
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  2. Rakesh Shukla
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  3. Ramu Ram
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  4. Avesh Kumar Tyagi
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  5. Ashutosh Dash
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  6. Meera Venkatesh
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Correspondence to Ashutosh Dash.

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Chakravarty, R., Shukla, R., Ram, R. et al. Practicality of Tetragonal Nano-Zirconia as a Prospective Sorbent in the Preparation of 99Mo/99mTc Generator for Biomedical Applications. Chroma 72, 875–884 (2010). https://doi.org/10.1365/s10337-010-1754-z

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  • DOI: https://doi.org/10.1365/s10337-010-1754-z

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