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Genes associated with addiction

Alcoholism, opiate, and cocaine addiction

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Abstract

Drug addiction is a complex disorder that has a large spectrum of causes. Vulnerability to addiction has been shown in twin studies to have a robust genetic component. This genetic basis for addiction has general and specific components for each drug abused. Although many genes have been implicated in drug addiction, only a handful have either been replicated to have an association or to have an identified functional mechanism related to specific effects of abused drugs. A few selected genetic variants that currently look promising for the study of alcohol, opiate, and cocaine addiction are discussed in this article.

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  1. Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, 10021, New York, NY

    Mary Jeanne Kreek, David A. Nielsen & K. Steven LaForge

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Kreek, M.J., Nielsen, D.A. & LaForge, K.S. Genes associated with addiction. Neuromol Med 5, 85–108 (2004). https://doi.org/10.1385/NMM:5:1:085

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