A New Isocoumarin from Fermentation Products of Endophytic Fungus of Aspergillus versicolor

Bing-Kun Ji; Wei Dong; Yue-De Wang; Kun Zhou; Yin-Ke Li; Min Zhou; Gang Du; Qiu-Fen Hu; Yan-Qing Ye; Hai-Ying Yang

doi:10.14233/ajchem.2015.18732

Issue

Vol. 27 No. 10 (2015): Vol 27 Issue 10

Issue Published : June 22, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

A New Isocoumarin from Fermentation Products of Endophytic Fungus of Aspergillus versicolor

https://doi.org/10.14233/ajchem.2015.18732

Bing-Kun Ji

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Wei Dong

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Yue-De Wang

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Kun Zhou

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Yin-Ke Li

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Min Zhou

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Gang Du

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Qiu-Fen Hu

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Yan-Qing Ye

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Hai-Ying Yang

Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, P.R. China

Corresponding Author(s) : Hai-Ying Yang

huqiufena@aliyun.com

Asian Journal of Chemistry, Vol. 27 No. 10 (2015): Vol 27 Issue 10
Article Published : June 23, 2015

Abstract

A new isocoumarin, versicoumarin D, was isolated from the fermentation products of an endophytic fungus Aspergillus versicolor. Its structure was elucidated by spectroscopic methods, including extensive 1D NMR and 2D NMR techniques. Compound 1 was also tested for its cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3 and MCF7) and it showed high cytotoxicity against A549 and MCF7 cell with IC₅₀ values of 5.8 and 8.0 μM, respectively.

Keywords

Versicoumarin D Isocoumarin Aspergillus versicolor Cytotoxicity

Ji, B.-K., Dong, W., Wang, Y.-D., Zhou, K., Li, Y.-K., Zhou, M., … Yang, H.-Y. (2015). A New Isocoumarin from Fermentation Products of Endophytic Fungus of Aspergillus versicolor. Asian Journal of Chemistry, 27(10), 3915–3916. https://doi.org/10.14233/ajchem.2015.18732

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References

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References

Y. Liang, W. Zhao, J.P. Xu and J.D. Miller, Int. Biodeter. Biodegrad., 65, 217 (2011); doi:10.1016/j.ibiod.2010.11.005.

J.M. Restrepo-Florez, A. Bassi and M.R. Thompson, Int. Biodeter. Biodegrad., 88, 83 (2014); doi:10.1016/j.ibiod.2013.12.014.

R.X. Li, S.X. Chen, S.B. Niu, L.D. Guo, J. Yin and Y.S. Che, Fitoterapia, 96, 88 (2014); doi:10.1016/j.fitote.2014.04.013.

U.W. Hawas, A.A. El-Beih and A.M. El-Halawany, Arch. Pharm. Res., 35, 1749 (2012); doi:10.1007/s12272-012-1006-x.

M. Figueroa, H. Raja, J.O. Falkinham III, A.F. Adcock, D.J. Kroll, M.C. Wani, C.J. Pearce and N.H. Oberlies, J. Nat. Prod., 76, 1007 (2013); doi:10.1021/np3008842.

J. Qi, C.L. Shao, Z.Y. Li, L.S. Gan, X.M. Fu, W.T. Bian, H.Y. Zhao and C.Y. Wang, J. Nat. Prod., 76, 571 (2013); doi:10.1021/np3007556.

H.L. Jiang, X.H. Luo, X.Z. Wang, J.L. Yang, X.J. Yao, P. Crews, F.A. Valeriote and Q.X. Wu, Fitoterapia, 83, 1275 (2012); doi:10.1016/j.fitote.2012.06.005.

S.L. Luo, X.J. Huang, Y. Wang, R.W. Jiang, L. Wang, L.L. Bai, Q.L. Peng, C.L. Song, D.M. Zhang and W.C. Ye, Fitoterapia, 95, 115 (2014); doi:10.1016/j.fitote.2014.03.004.

J. Kornsakulkarn, C. Thongpanchang, S. Lapanun and K. Srichomthong, J. Nat. Prod., 72, 1341 (2009); doi:10.1021/np900082h.

K. Tianpanich, S. Prachya, S. Wiyakrutta, C. Mahidol, S. Ruchirawat and P. Kittakoop, J. Nat. Prod., 74, 79 (2011); doi:10.1021/np1003752.

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M. Shibano, H. Naito, M. Taniguchi, N.H. Wang and K. Baba, Chem. Pharm. Bull. (Tokyo), 54, 717 (2006); doi:10.1248/cpb.54.717.

Issue

Vol. 27 No. 10 (2015): Vol 27 Issue 10

A New Isocoumarin from Fermentation Products of Endophytic Fungus of Aspergillus versicolor

Corresponding Author(s) : Hai-Ying Yang

Abstract

Keywords

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