Abstract
Continuous-flow synthesis of coumarin was realized in a tandem microflow system containing two microreactors in this study. Generally, better reaction yield (91%) and less side reaction were obtained in the flow system compared with conventional method. Interestingly, different reaction pathways were observed between continuous-flow system and batch methods.
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Li, X., Chen, A., Zhou, Y. et al. Two-Stage Flow Synthesis of Coumarin via O-Acetylation of Salicylaldehyde. J Flow Chem 5, 82–86 (2015). https://doi.org/10.1556/1846.2014.00043
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DOI: https://doi.org/10.1556/1846.2014.00043