Abstract
Flow chemistry has attracted significant interest in pharmaceutical development, where substantial efforts have been directed toward the design of continuous processes. Here, we report a total synthesis of atropine in flow that features an unusual hydroxymethylation and separation of several byproducts with high structural similarity to atropine. Using a combination of careful pH control in three sequential liquid-liquid extractions and a functionalized resin, atropine is delivered by the flow system with >98% purity.
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Dai, C., Snead, D.R., Zhang, P. et al. Continuous-Flow Synthesis and Purification of Atropine with Sequential In-Line Separations of Structurally Similar Impurities. J Flow Chem 5, 133–138 (2015). https://doi.org/10.1556/1846.2015.00013
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DOI: https://doi.org/10.1556/1846.2015.00013