Abstract
The use of continuous-flow chemistry has shown to be an important tool in improving API manufacture. In the present paper, we report the use of continuous-flow reactors in the synthesis of the bicyclic side chain of antiretroviral Darunavir.
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Leão, R.A.C., de Lopes, R.O., Bezerra, M.A.d. et al. Studies on the Continuous-Flow Synthesis of Nonpeptidal bis-Tetrahydrofuran Moiety of Darunavir. J Flow Chem 5, 216–219 (2015). https://doi.org/10.1556/1846.2015.00031
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DOI: https://doi.org/10.1556/1846.2015.00031