Abstract
This work describes the manufacturing of ribociclib following the concept of an end-to-end continuous-flow process. The active pharmaceutical ingredient (API) is produced in a two-step telescoped flow process with integrated in-line liquid-liquid extraction and semibatch crystallization.
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Porta, R; Benaglia, M.; Puglisi, A. Org. Process Res. Dev. 2016, 20, 2–25
Ley, S. V.; Fitzpatrick, D. E.; Myers, R. M.; Battilocchio, C.; Ingham, R. J. Angew. Chem., Int. Ed. 2015, 54, 10122–10135
Teoh, S.; Rathi, C.; Sharratt, P. Org. Process Res. Dev. 2016, 20, 414–431
Gutmann, B.; Cantillo, D.; Kappe, O. Angew. Chem., Int. Ed. 2015, 54, 6688–6728
Ott, D.; Kralisch, D.; Dencic, I.; Hessel, V.; Laribi, Y.; Perrichon, P. D.; Berguerand, C.; Kiwi-Minsker, L.; Loeb, P. ChemSusChem 2014, 7, 3521–3533
Elvira, K. S.; Casadevall I Solvas, X.; Wootton, R. C. R.; deMello, A. J. Nature Chem. 2013, 5, 905–915
Baumann, M.; Baxendale; I. R. Beilstein J. Org. Chem. 2015, 11, 1194–1219
Newman, S. G.; Jensen, K. F. Green Chem. 2013, 15, 1456–1472.
Ley, S. V.; Fitzpatrick, D. E.; Ingham, R. J.; Myers, R. M. Angew. Chem., Int. Ed. 2015, 54, 3449–3464
Plumb, K. Chem. Eng. Res. Des. 2005, 83, 730
Snead, D. R.; Jamison, T. F. Chem. Sci. 2013, 4, 2822–2827
Dencic, I.; Ott, D.; Kralisch, D.; Noel, T.; Meuldijk, J.; de Croon, M.; Hessel, V.; Laribi, Y.; Perrichon, P. Org. Process Res. Dev. 2014, 18, 1326–1338.
HiTec Zang. http://www.hitec-zang.com (accessed Jun 28, 2016).
Bronkhorst Schweiz. http://www.bronkhorst.ch/ (accessed Jun 28, 2016).
Besong, G.; Brain, C. T.; Brooks, C. A.; Congreve, M. S.; Dagostin, C.; He, G.; Hou, Y.; Howard, S.; Li, Y.; Lu, Y.; Mortenson, P.; Smith, T.; Sung, M.; Woodhead, S.; Wrona, W. WO2010/020675
Calienni, J. V.; Chen, G.-P.; Gong, B.; Kapa, P. K.; Saxena, V. US 2012/0115878
Sumi, N. J.; Kuenzi, B. M.; Knezevic, C. E.; Remsing Rix, L. L.; Rix, R. ACS Chem. Biol. 2015, 10, 2680–2686.
Calienni, J. V.; Chen, G.-P.; Gong, B.; Kapa, P. K.; Saxena, V. WO2012/064805A1##.
For example: (a) Latimer, D.; Wiebe, M. Green Chem. 2015, 8, 39–42
Qian, G.; Liu, B.; Tan, Q.; Zhang, S.; Yu, B. Eur. J. Org. Chem. 2014, 4837–4843
Ackermann, L.; Lygin, A. V. Org. Lett. 2012, 14, 764–767.
For example: (a) Islam, K.; Chin, H. F.; Olivares, A. O.; Saunders, L. P.; de La Cruz, E. M.; Kapoor, T. M. Angew. Chem., Int. Ed. 2010, 49, 8484–8488
Zucca, C.; Bravo, P.; Volonterio, A.; Zanda, M.; Wagner, A.; Mioskowski, C. Tetrahedron Lett. 2001, 42, 1033–1035.
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Pellegatti, L., Hafner, A. & Sedelmeier, J. A Two-Step Continuous-Flow Procedure towards Ribociclib. J Flow Chem 6, 198–201 (2016). https://doi.org/10.1556/1846.2016.00017
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DOI: https://doi.org/10.1556/1846.2016.00017