Abstract
Titanium foams fabricated by a new powder metallurgical process have bimodal pore distribution architecture (i.e., macropores and micropores), mimicking natural bone. The mechanical properties of the titanium foam with low relative densities of approximately 0.20–0.30 are close to those of human cancellous bone. Also, mechanical properties of the titanium foams with high relative densities of approximately 0.50–0.65 are close to those of human cortical bone. Furthermore, titanium foams exhibit good ability to form a bonelike apatite layer throughout the foams after pretreatment with a simple thermochemical process and then immersion in a simulated body fluid. The present study illustrates the feasibility of using the titanium foams as implant materials in bone tissue engineering applications, highlighting their excellent biomechanical properties and bioactivity.
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References
D.F. Williams, in Titanium in Medicine, edited by D.M. Brunette, P. Tengvall, M. Textor, and P. Thomsen (Springer-Verlag, Heidelberg, Germany, 2001), p. 13.
T. Hanawa, in The Bone-Biomaterial Interface, edited by J.E. Davies (University of Toronto Press, 1991), p. 49.
T. Kokubo, K. Sawada, K. Hirakawa, C. Shimizu, T. Takamatsu, and Y. Hirasawa, J. Biomed. Mater. Res. 45, 363 (1999).
T. Kokubo, Thermochim. Acta 280/281, 479 (1996).
K. Wang, L. Gustavson, and J. Dumbleton, in Beta Titanium in the 1990’s, edited by D. Eylon, R.R. Boyer, and D.A. Koss (TMS, Warrendale, PA, 1993), pp. 49–60.
K. Wang, L. Gustavson, and J. Dumbleton, in Titanium ’92 Science and Technology, edited by F.H. Froes and I. Caplan (TMS, Warrendale, PA, 1992), pp. 2697–2704.
S.G. Steinemann, P.A. Mäusli, S. Szmukler-Moncler, O. Pohler, H.E. Hintermann, and S.M. Perren, in Titanium ’92 Science and Technology, edited by F.H. Froes and I. Caplan (TMS, Warrendale, PA, 1993), pp. 2689–2696.
Y. Okazaki, Y. Ito, A. Ito, and T. Tateishi, Mater. Trans. JIM 34, 1217 (1993).
P. Kovacs and J.A. Davidson, in Titanium ’92 Science and Technology, edited by F.H. Froes and I. Caplan (TMS, Warrendale, PA, 1993), pp. 2705–2712.
A.K. Mishra, J.A. Davidson, P. Kovacs, and R.A. Poggie, in Beta Titanium in the 1990’s, edited by D. Eylon, R.R. Boyer, and D.A. Koss (TMS, Warrendale, PA, 1993), pp. 61–72.
M. Niinomi, D. Kuroda, K. Fukunaga, M. Morinaga, Y. Kato, T. Yashiro, and A. Suzuki, Mater. Sci. Eng. A 263, 193 (1999).
T. Ahmed, M. Long, J. Silvestri, C. Ruiz, and H.J. Rack, presented at the 8th World Titanium Conference (Birmingham, U.K., October, 1995).
V.I. Sikavitsas, J.S. Temenoff, and A.G. Mikos, Biomater. 22, 2581 (2001).
K.A. Athanasiou, C.M. Agrawal, F.A. Barber, and S.S. Burkhart, Arthroscopy 14, 726 (1998).
S. Gogolewski, Injury 31, 28 (2000).
W.L. Murphy, D.H. Kohn, and D.J. Mooney, J. Biomed. Mater. Res. 50, 50 (2000).
M.E. Gomes, A.S. Ribeiro, P.B. Malafaya, R.L. Reis, and A.M. Cunha, Biomater. 22, 883 (2001).
J. Dong, H. Kojima, T. Uemura, M. Kikuchi, T. Tateishi, and J. Tananka, J. Biomed. Mater. Res. 57, 208 (2001).
D.W. Hutmacher, Biomater. 21, 2529 (2000).
U. Ripamonti and A.H. Reddi, Critical Reviews in Oral Biology and Medicine 8, 154 (1997).
M.W. Lawless, R.T. Laughlin, J.M. Kerpsack, and D. Pisut, J. Musculoskeletal Res. 4, 129 (2000).
H. Kienapfel, C. Sprey, A. Wilke, and P. Griss, J. Arthroplasty 14, 355 (1999).
Y.S. Chang, M. Oka, M. Kobayashi, H.O. Gu, Y. Ikada, Z.L. Li, and T. Nakamura, Biomater. 17, 1141 (1996).
K.H.W. Seah, R. Thampuran, and S.H. Teoh, Corros. Sci. 40, 547 (1998).
L.D. Zardiakas, D.E. Parsell, L.D. Dillon, D.W. Mitchell, L.A. Nunnery, and R. Poggie, J. Biomed. Mater. Res. 58, 180 (2001).
G. Magliulo, R. D’Amico, and M. Forino, J. Otolaryngol. 30, 330 (2001).
C.H. Hartwig, L. Rehák, S. Milz, K.U. Benner, W. Küsswetter, and G. Willmann, Biomed. Technol. 40, 99 (1995).
H. Elema, J.H. De Groot, A.J. Nijenhuis, A.J. Pennings, R.P.H. Veth, J. Klompmaker, and H.W.B. Jansen, Colloid Polymer Sci. 268, 1082 (1990).
Y. Yamada, K. Shimojima, Y. Sagaguchi, M. Mabuchi, M. Nakamura, T. Asahina, T. Mukai, H. Kanahashi, and K. Higashi, Adv. Eng. Mater. 2, 184 (2000).
C.E. Wen, M. Mabuchi, Y. Yamada, K. Shimojima, Y. Chino, and T. Asahina, Scripta Mater. 45, 1147 (2001).
H.M. Kim, F. Miyaji, T. Kokubo, and T. Nakamura, J. Biomed. Mater. Res. 32, 409 (1996).
T. Kokubo, H. Kushitani, S. Sakka, T. Kitsugi, and T. Yamamuro, J. Biomed. Mater. Res. 24, 721 (1990).
Y.S. Chang, M. Oka, T. Nakamura, and H.O. Gu, J. Biomed. Mater. Res. 30, 117 (1996).
C. Zhang, J.X. Wang, and X.D. Zhang, J. Biomed. Mater. Res. 52, 354 (2000).
F.G. Evans, Artif. Limbs 13, 37 (1969).
E.W. Morscher and W. Dick, Clin. Orthop. Rel. Res. 176, 77 (1986).
G. Heimke, R.J. Kolbe, and J.R. Latour, J. Mater. Sci. Med. 3, 204 (1992).
T. Mukai, H. Kanahashi, Y. Yamada, K. Shimojima, M. Mabuchi, T.G. Nieh, and K. Higashi, Scripta Mater. 41, 365 (1999).
Y. Yamada, K. Shimojima, Y. Sakaguchi, M. Mabuchi, M. Nakamura, T. Asahina, T. Mukai, H. Kanahashi, and K. Higashi, Mater. Sci. Eng. A 280, 225 (2000).
C.E. Wen, Y. Yamada, K. Shimojima, M. Mabuchi, M. Nakamura, T. Asahina, T. Aizawa, and K. Higashi, Mater. Trans. JIM 41, 1192 (2000).
H. Nakajima, S.K. Hyun, K. Ohashi, K. Ota, and K. Murakami, Colloids and Surfaces A: Physicochem. Eng. Aspects 179, 209 (2001).
T.G. Nieh, K. Higashi, and J. Wadsworth, Mater. Sci. Eng. A 283, 105 (2000).
L.G. Gibson and M.F. Ashby, Cellular Solids: Structure and Properties, 2nd ed. (Cambridge University Press, Cambridge, U.K., 1997), pp. 429–452.
M. Long and H.J. Rack, Biomater. 19, 1621 (1998).
M. Uchida, H.M. Kim, T. Kokubo, and T. Nakamura, J. Am. Ceram. Soc. 84, 2969 (2001).
B.D. Ratner, J. Biomed. Mater. Res. Appl. Biomater. 21, 59 (1987).
T. Hanawa, in The Bone-Biomaterial Interface, edited by J.E. Davies (University of Toronto Press, Toronto, Canada, 1991), pp. 49–61.
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Wen, C.E., Yamada, Y., Shimojima, K. et al. Novel titanium foam for bone tissue engineering. Journal of Materials Research 17, 2633–2639 (2002). https://doi.org/10.1557/JMR.2002.0382
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DOI: https://doi.org/10.1557/JMR.2002.0382