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A multifunctional poly(acrylic acid)/gelatin hydrogel

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Abstract

A poly(acrylic acid)/gelatin interpenetrating network hydrogel was synthesized by aqueous solution polymerization. The influences of preparation conditions including cross-linker, initiator, gelatin content, and neutralization degree on the swelling ratios of the hydrogels are investigated. The swelling, mechanical strength, biodegradability, and drug-release properties of poly(acrylic acid)/gelatin hydrogel are evaluated. The hydrogel has excellent mechanical properties; tensile strength is 1500 kPa, and elongation at break is 887%, respectively. The in vitro biodegradation shows that an interpenetrating network structure exists in the poly(acrylic acid)/gelatin hybrid hydrogel. A release study indicates that the theophylline release from the hydrogel depends on the cross-linking density of the hydrogel and pH of the medium, and the drug diffusion obeys an anomalous transport model.

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Authors and Affiliations

  1. The Key Laboratory for Functional Materials of Fujian Higher Education Institute of Materials Physical Chemistry, Huaqiao University, Quanzhou, 362021, China

    Qunwei Tang, Jihuai Wu, Jianming Lin, Shijun Fan & De Hu

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  1. Qunwei Tang
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  2. Jihuai Wu
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  3. Jianming Lin
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  4. Shijun Fan
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  5. De Hu
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Correspondence to Jihuai Wu.

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Tang, Q., Wu, J., Lin, J. et al. A multifunctional poly(acrylic acid)/gelatin hydrogel. Journal of Materials Research 24, 1653–1661 (2009). https://doi.org/10.1557/jmr.2009.0210

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