Complete Response of a Patient with Advanced Primary Splenic Histiocytic Sarcoma by Treatment with Chemotherapeutic Drugs Selected Using the Collagen Gel Droplet-embedded Culture Drug Sensitivity Test

Yasunori Yamamoto; Yoichi Hiasa; Masashi Hirooka; Yohei Koizumi; Satoru Takeji; Yoshio Tokumoto; Eiji Tsubouchi; Yoshio Ikeda; Masanori Abe; Bunzo Matsuura; Morikazu Onji

doi:10.2169/internalmedicine.51.8325

CASE REPORTS

Complete Response of a Patient with Advanced Primary Splenic Histiocytic Sarcoma by Treatment with Chemotherapeutic Drugs Selected Using the Collagen Gel Droplet-embedded Culture Drug Sensitivity Test

Yasunori Yamamoto, Yoichi Hiasa, Masashi Hirooka, Yohei Koizumi, Satoru Takeji, Yoshio Tokumoto, Eiji Tsubouchi, Yoshio Ikeda, Masanori Abe, Bunzo Matsuura, Morikazu Onji

Author information

Yasunori Yamamoto
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
Yoichi Hiasa
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
Masashi Hirooka
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
Yohei Koizumi
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
Satoru Takeji
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
Yoshio Tokumoto
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
Eiji Tsubouchi
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
Yoshio Ikeda
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
Masanori Abe
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
Bunzo Matsuura
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
Morikazu Onji
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan

Keywords: splenic histiocytic sarcoma, collagen gel droplet-embedded culture drug sensitivity test, hepatic arterial infusion chemotherapy, mitomycin C, etoposide

JOURNAL OPEN ACCESS

2012 Volume 51 Issue 20 Pages 2893-2897

DOI https://doi.org/10.2169/internalmedicine.51.8325

Details

Abstract

A 69-year-old man presented with multiple nodules on the spleen and liver that had been detected by computed tomography (CT). A liver tumor biopsy was performed, and the patient was diagnosed to have histiocytic sarcoma (HS). Splenectomy was performed, and the chemosensitivity of the spleen tumor was measured using the collagen gel droplet-embedded culture drug sensitivity test (CD-DST). Hepatic arterial infusion chemotherapy was administered, based on the results of the CD-DST. The patient achieved complete remission (CR) after this therapy and remained alive without recurrence at the final follow-up. This is the first known case of CR in response to chemotherapy for advanced splenic HS.

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