Abstract
Expressed protein ligation has become a frequently used technique to insert non-standard amino acids into proteins. The technique has been adapted to insert selenocysteine residues in place of cysteine residue in proteins, taking advantage of the similarity in the chemistries of sulfur and selenium. This replacement can confer unique structural and catalytic properties to enzymes and proteins. The development of this technique also allows for naturally occurring selenoproteins to be produced semisynthetically.
Keywords: selenocysteine, expressed protein ligation, thioredoxin reductase, semisynthetic
Protein & Peptide Letters
Title: Incorporation of Selenocysteine into Proteins Using Peptide Ligation
Volume: 12 Issue: 8
Author(s): Robert J. Hondal
Affiliation:
Keywords: selenocysteine, expressed protein ligation, thioredoxin reductase, semisynthetic
Abstract: Expressed protein ligation has become a frequently used technique to insert non-standard amino acids into proteins. The technique has been adapted to insert selenocysteine residues in place of cysteine residue in proteins, taking advantage of the similarity in the chemistries of sulfur and selenium. This replacement can confer unique structural and catalytic properties to enzymes and proteins. The development of this technique also allows for naturally occurring selenoproteins to be produced semisynthetically.
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Cite this article as:
Hondal J. Robert, Incorporation of Selenocysteine into Proteins Using Peptide Ligation, Protein & Peptide Letters 2005; 12 (8) . https://dx.doi.org/10.2174/0929866054864319
DOI https://dx.doi.org/10.2174/0929866054864319 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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