Abstract
Cellulose is a natural linear biopolymer, which is constituted of an assembly of cellulose nanofibrils in a hierarchical order. Nanocelluloses in particular show great promise as a cost-effective advanced material for biomedical applications because of their biocompatibility, biodegradability, and low cytotoxicity. Moreover, with their chemical functionality they can be easily modified to yield useful products. While nature uses the hierarchical nanostructure of cellulose as the load-bearing constituent in plants, a significant amount of research has been directed toward the fabrication of advanced cellulosic materials with various nanostructures and functional properties. Such nanocelluloses are widely applied in medical implants, tissue engineering, drug delivery, wound healing, diagnostics, and other medical applications with real examples in this field. There are also emerging fields being developed to use nanocelluloses and their composites in more novel ways in biomedical applications such as 3D printing and magnetically responsive materials. In this mini-review, recent advances in the design and fabrication of nanocellulose-based materials and composites are presented with a special emphasis on their suitability for material requirements for biomedical applications as well as the new directions and challenges that the materials might face in the future.
Keywords: Nanocellulose, drug delivery, diagnostics, wound healing, implants, tissue engineering, bacterial cellulose, cellulose nanocrystals.
Current Medicinal Chemistry
Title:Nanocellulose and its Composites for Biomedical Applications
Volume: 24 Issue: 5
Author(s): Ahu Gumrah Dumanli*
Affiliation:
- Department of Chemistry, University of Cambridge, Cambridge,United Kingdom
Keywords: Nanocellulose, drug delivery, diagnostics, wound healing, implants, tissue engineering, bacterial cellulose, cellulose nanocrystals.
Abstract: Cellulose is a natural linear biopolymer, which is constituted of an assembly of cellulose nanofibrils in a hierarchical order. Nanocelluloses in particular show great promise as a cost-effective advanced material for biomedical applications because of their biocompatibility, biodegradability, and low cytotoxicity. Moreover, with their chemical functionality they can be easily modified to yield useful products. While nature uses the hierarchical nanostructure of cellulose as the load-bearing constituent in plants, a significant amount of research has been directed toward the fabrication of advanced cellulosic materials with various nanostructures and functional properties. Such nanocelluloses are widely applied in medical implants, tissue engineering, drug delivery, wound healing, diagnostics, and other medical applications with real examples in this field. There are also emerging fields being developed to use nanocelluloses and their composites in more novel ways in biomedical applications such as 3D printing and magnetically responsive materials. In this mini-review, recent advances in the design and fabrication of nanocellulose-based materials and composites are presented with a special emphasis on their suitability for material requirements for biomedical applications as well as the new directions and challenges that the materials might face in the future.
Export Options
About this article
Cite this article as:
Dumanli Gumrah Ahu*, Nanocellulose and its Composites for Biomedical Applications, Current Medicinal Chemistry 2017; 24 (5) . https://dx.doi.org/10.2174/0929867323666161014124008
DOI https://dx.doi.org/10.2174/0929867323666161014124008 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Statins and Infrainguinal Vascular Bypass Procedures
Current Vascular Pharmacology Nanomaterial Based Approaches for the Diagnosis and Therapy of Cardiovascular Diseases
Current Pharmaceutical Design Roles of IL-6-gp130 Signaling in Vascular Inflammation
Current Cardiology Reviews Editorial: Lipoprotein (a), More than Just Cholesterol?
Current Medicinal Chemistry A More Accurate Approach to Molecular Genetics Analysis in Vascular Disease
Cardiovascular & Hematological Disorders-Drug Targets Fenofibrate and Telmisartan in the Management of Abdominal Aortic Aneurysm
Current Drug Targets Minocycline Mediated Mitochondrial Cytoprotection: Premises for Therapy of Cerebrovascular and Neurodegenerative Diseases
Current Drug Targets Prospective for Diagnosis and Treatment of Diabetic Retinopathy
Current Pharmaceutical Design A Review of Artificial Intelligence in Cerebrovascular Disease Imaging: Applications and Challenges
Current Neuropharmacology Subject Index to Volume 9
Current Pharmaceutical Design MMP-9 Inhibitors in the Brain: Can Old Bullets Shoot New Targets?
Current Pharmaceutical Design Pharmacophore and 3D QSAR Study of TGFβ Inhibitors
Letters in Drug Design & Discovery Inhibitors of the Proteolytic Activity of Urokinase Type Plasminogen Activator
Current Pharmaceutical Design Protein-Energy Malnutrition Alters Thermoregulatory Homeostasis and the Response to Brain Ischemia
Current Neurovascular Research Immunotherapy, Vascular Pathology, and Microhemorrhages in Transgenic Mice
CNS & Neurological Disorders - Drug Targets Circulating miR-126 as a Potential Non-invasive Biomarker for Intracranial Aneurysmal Rupture: A Pilot Study
Current Neurovascular Research Sex Differences in Biomarkers for Predicting Cardiovascular and Coronary Events
Current Vascular Pharmacology New therapeutic effects of cilostazol in patients with ischemic disorders
Current Vascular Pharmacology Different Factors Influence Recanalisation Rate After Coiling in Ruptured and Unruptured Intracranial Aneurysms
CNS & Neurological Disorders - Drug Targets Renal Nerve Ablation for Hypertensive Patients with Chronic Kidney Disease
Current Vascular Pharmacology