Abstract
Background: Recent studies have identified the correlation between dementia and certain vocal features, such as voice and speech changes. Vocal features may act as early markers of Alzheimer's disease (AD). Despite being present in non-pathological senescence and Mild Cognitive Impairment, especially in its amnesic subtype (aMCI), these voice- and speech-related symptoms are the first signs of AD. The purpose of this study is to verify whether these signs are related to deficits in lexical access, which appear early in AD.
Method: Anomic deficits in persons with MCI and AD are assessed through tests on verbal memory, denomination by confrontation, and verbal fluency. In addition, an acoustic analysis of speech is conducted in a reading task to identify the acoustic parameters associated with the groups analyzed, and their relation to the degree of anomic impairment observed in each one of them.
Results and Conclusions: The results show a direct relationship between the different acoustic parameters present in AD and the verbal fluency tests results.
Keywords: Alzheimer's disease, mild cognitive impairment, anomic aphasia, acoustic analysis, speech, memory.
Current Alzheimer Research
Title:Voice Markers of Lexical Access in Mild Cognitive Impairment and Alzheimer's Disease
Volume: 15 Issue: 2
Author(s): Juan J.G. Meilan*, Francisco Martinez-Sanchez, Juan Carro, Nuria Carcavilla and Olga Ivanova
Affiliation:
- Faculty of Psychology, University of Salamanca, Campus Ciudad Jardin-Avenida de la Merced 109-131, 37005 Salamanca,Spain
Keywords: Alzheimer's disease, mild cognitive impairment, anomic aphasia, acoustic analysis, speech, memory.
Abstract: Background: Recent studies have identified the correlation between dementia and certain vocal features, such as voice and speech changes. Vocal features may act as early markers of Alzheimer's disease (AD). Despite being present in non-pathological senescence and Mild Cognitive Impairment, especially in its amnesic subtype (aMCI), these voice- and speech-related symptoms are the first signs of AD. The purpose of this study is to verify whether these signs are related to deficits in lexical access, which appear early in AD.
Method: Anomic deficits in persons with MCI and AD are assessed through tests on verbal memory, denomination by confrontation, and verbal fluency. In addition, an acoustic analysis of speech is conducted in a reading task to identify the acoustic parameters associated with the groups analyzed, and their relation to the degree of anomic impairment observed in each one of them.
Results and Conclusions: The results show a direct relationship between the different acoustic parameters present in AD and the verbal fluency tests results.
Export Options
About this article
Cite this article as:
Meilan J.G. Juan*, Martinez-Sanchez Francisco, Carro Juan, Carcavilla Nuria and Ivanova Olga, Voice Markers of Lexical Access in Mild Cognitive Impairment and Alzheimer's Disease, Current Alzheimer Research 2018; 15 (2) . https://dx.doi.org/10.2174/1567205014666170829112439
DOI https://dx.doi.org/10.2174/1567205014666170829112439 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
New Advances in the Prevention, Diagnosis, Treatment, and Rehabilitation of Alzheimer's Disease
Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
Diagnostic and therapeutic biomarkers of dementia
Dementia affects 18 million people worldwide. Dementia is a syndrome of symptoms caused by brain disease, usually chronic or progressive, clinically characterized by multiple impairments of higher cortical functions such as memory, thinking, orientation, and learning. In addition, in the course of dementia, cognitive deficits are observed, which often hinder ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Medicinal Chemistry of the Epigenetic Diet and Caloric Restriction
Current Medicinal Chemistry SPECT Radiopharmaceuticals for Dementia
Current Radiopharmaceuticals NMDA Receptor Antagonists as Antidepressant and Antidementia Drugs: Recent Developments and Future Prospects
Current Medicinal Chemistry - Central Nervous System Agents Cannabis Epidemiology: A Selective Review
Current Pharmaceutical Design Impacting Neuronal and Vascular Cellular Signal Transduction through the Metabotropic Glutamate Receptor System
Medicinal Chemistry Reviews - Online (Discontinued) Microglial Proteases: Strategic Targets for Neuroprotective Agents
Current Neuropharmacology Cognitive Impairment and Diabetes
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery A Novel Prescription for Alzheimer’s Disease: Targeting Hypercoagulable States
Current Neurovascular Research A Review on the Effects of Testosterone Supplementation in Hypogonadal Men with Cognitive Impairment
Current Drug Targets Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes-A Possible Link
Current Neuropharmacology The Clinical Neuroscience of Post Stroke Depression
Current Neuropharmacology Oxidative Stress and Antioxidant Potential of One Hundred Medicinal Plants
Current Topics in Medicinal Chemistry Preface: What is Aging for? That Remains the Question
Current Aging Science Complications Associated with Recombinant Tissue Plasminogen Activator Therapy for Acute Ischaemic Stroke
CNS & Neurological Disorders - Drug Targets The Adult Patient with Eisenmenger Syndrome: A Medical Update after Dana Point Part II: Medical Treatment - Study Results
Current Cardiology Reviews Mechanisms of Cortical Neural Synchronization Related to Healthy and Impaired Consciousness: Evidence by Quantitative Electroencephalographic Studies
Current Pharmaceutical Design Administration of Exogenous Surfactant and Cytosolic Phospholipase A2α Inhibitors may Help COVID-19 Infected Patients with Chronic Diseases
Coronaviruses Editorial Thematic Issue: Targeting Synaptic Dysfunction and Neural Connectivity in Neurological and Psychiatric Disorders
Current Pharmaceutical Design Delayed Treatment with Nicotinamide Inhibits Brain Energy Depletion,Improves Cerebral Microperfusion, Reduces Brain Infarct Volume, but does not Alter Neurobehavioral Outcome Following Permanent Focal Cerebral Ischemia in Sprague Dawley Rats
Current Neurovascular Research Therapeutic Potential of Hepatocyte Growth Factor for Treating Neurological Diseases
Current Drug Therapy