Multifunctionalized Microbubbles for Cancer Diagnosis and Therapy

Hao      Li; Jianhao      Wang; Gang      Huang; Ping      Wang; Rongqin      Zheng; Chao      Zhang; Qing      Jiang

Abstract

Microbubbles (MBs) are gas-filled hollow microparticles. Under the ultrasound field, the difference of acoustic characteristics between gas and plasma in the blood vessel will cause strong impedance mismatch and echogenicity to enhance ultrasonic grey scale imaging. The linear or nonlinear resonance of MB shell in the ultrasound field would lead to repeated expansion-contraction till destruction. In this case, the pre-loaded drug in the MB shell will be released in an accelerated manner triggered by the ultrasound at a probe–given site. Sonoporation effect of the cell membrane would also help increase the uptake of substances into cells. This paper is dedicated to review recent developments on MBs, especially multifunctionalized MBs, as a potential drug/gene delivery microdevices for both diagnosis and therapy of malignant tumors.

Keywords: Microbubbles, Multifunctionalization, Cancer diagnosis, Cancer therapy, Contrast-enhanced ultrasonic imaging, Drug delivery system, Tumor-targeting, prostatectomy tissues, Phospholipid Microbubbles.