Circadian rhythm of human salivary chromogranin A

Rei DEN; Masahiro TODA; Shingo NAGASAWA; Kazuyuki KITAMURA; Kanehisa MORIMOTO

doi:10.2220/biomedres.28.57

Communication

Circadian rhythm of human salivary chromogranin A

Rei DEN, Masahiro TODA, Shingo NAGASAWA, Kazuyuki KITAMURA, Kanehisa MORIMOTO

Author information

JOURNAL FREE ACCESS

2007 Volume 28 Issue 1 Pages 57-60

DOI https://doi.org/10.2220/biomedres.28.57

Details

Abstract

We investigated the circadian rhythm of chromogranin A (CgA) concentrations in saliva and blood samples from 40 male college students collected at 7 : 00, 8 : 00, 10 : 30, 12 : 30, 17 : 30, and 22 : 30. CgA concentrations were determined by ELISA. Salivary CgA levels peaked upon awakening, and then quickly decreased to the nadir after 1 hour and maintained a low level throughout the day. On the other hand, plasma CgA did not show any obvious circadian rhythm. These findings suggest that salivary and plasma CgA has different routes of secretion.

Corresponding author

Register with J-STAGE for free!