Acta Periodica Technologica 2010 Issue 41, Pages: 159-168
https://doi.org/10.2298/APT1041159J
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Chromatographic behavior and lipophilicity of s-triazine derivatives on silica gel impregnated with paraffin oil
Jevrić Lidija R.
Koprivica Gordana B.
Mišljenović Nevena M.
Jovanović Bratislav Ž.
The chromatographic behavior of four group of s-triazine derivatives (14
compounds) has been studied by TLC on silica gel impregnated with paraffin
oil. Retention mechanism has been determined using the following mobile
phases: water-acetone, water-acetonitrile, water-dioxane,
water-tetrahydrofuran, water-methanol and water-ethanol, by changing the
volume fraction of modifier in the mobile phase. On impregnated silica gel, a
reversed-phase chromatographic process occurs. Good correlation was obtained
between the retention constants, RM 0 (determined by linear extrapolation),
and slope, S, of chromatographic equations. There was also satisfactory
correlation between these retention constants and logP values calculated
using different theoretical methods. The study showed that the retention
constants can be used as a measure of lipophilicity of investigated
compounds.
Keywords: s-Triazine derivatives, RP-TLC, impregnated silica gel, multiple linear regression analysis, lipophilicity
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