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Synthesis and characterization of novel substituted spiro[isobenzofuran-1(3H), 9’-xanthene]-3-ones

Patel Sachin.V. (Deparment of Chemistry, Sardar Patel University Gujarat, India)
Patel Manish P. (Deparment of Chemistry, Sardar Patel University Gujarat, India)
Patel Rangan G. (Deparment of Chemistry, Sardar Patel University Gujarat, India)

The ketoacid, 2-(4-diethylamino-2-hydroxybenzoyl)benzoic acid, prepared from N,N-diethyl-m-aminophenol and phthalic anhydride, was reacted with various substituted 3-[6-methoxybenzothiazol-2-yl]-4(3H)-quinazolinones in the presence of a dehydration condensing agent to afford novel spiro[isobenzofuran-1(3H),9’-xanthene]-3-ones. The benzothiazolyl quinazolinones were synthesized by reacting 2-amino-6-methoxybenzothiazole with various substituted benzoxazinones. All compounds were characterized by melting point determination, elemental analysis, infra- red spectroscopy NMR-spectroscopy and UV-visible sprectroscopy. All the fluoran compounds are colourless or nearly colourless and produce colour in the presence of acidic media.

Keywords: synthesis, ketoacid, fluoran, benzothiazolyl quinazolinone