Vojnosanitetski pregled 2014 Volume 71, Issue 8, Pages: 780-783
https://doi.org/10.2298/VSP1408780P
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Cited by
Asymptomatic flow of Rosai-Dorfman disease
Petrović Dragan (Faculty of Medicine, Clinic of Stomatology, Department of Maxillofacial Surgery, Niš)
Mihailović Dragan (Faculty of Medicine, Clinic of Stomatology, Department of Pathology, Niš)
Petrović Slađana (Faculty of Medicine, Clinic of Stomatology, Department of Radiology, Niš)
Živković Nikola (Faculty of Medicine, Clinic of Stomatology, Department of Pathology, Niš)
Mijović Žaklina (Faculty of Medicine, Clinic of Stomatology, Department of Pathology, Niš)
Bjelaković Bojko (Faculty of Medicine, Clinic of Stomatology, Department of Pediatrics, Niš)
Kostić Miloš (Faculty of Medicine, Clinic of Stomatology, Department of Immunology, Niš)
Kesić Ljiljana (Faculty of Medicine, Clinic of Stomatology, Department of Oral Medicine, Niš)
Stanković Ana (Clinical Center of Niš, Clinic of Oncology, Niš)
Petrović Milica (Faculty of Medicine, Clinic of Stomatology, Department of Oral Medicine, Niš)
Vučković Ivica (Faculty of Medicine, Clinic of Stomatology, Department of Maxillofacial Surgery, Niš)
Introduction. Sinus histiocytosis with massive lymphadenopathy is a rare
benign self-limiting disease of unknown etiology. The salivary gland
involvement, indicating the extranodal character of the disease, often
presents a diagnostic dilemma requiring immunohistochemical staining of
surgically removed tumor to confirm the diagnosis. Case report. We report a
43-year-old man presented with an asymptomatic mass in the left mandibular
angle. On physical examination, the lesion was described as a painless,
mobile, firm-elastic consistency nodule, which measured 4 × 3 cm in diameter,
with normal overlying skin. A mass with the same characteristics, dimensions
2 × 2 cm, was also noted in the right parotid region. No other changes in
regional lymph nodes were detected. On macroscopic examination the lesion was
firm, multilobulated, yellowish and rounded, while on microscopic examination
the lesion was composed almost entirely of polygonal histiocytes with
abundant cytoplasm, emperipolesis, plasma cells arranged in sheets, and
lymphocytes scattered or within clusters. The observed histiocytes were found
to be CD68 and S100 protein positive. Conclusion. Rosai-Dorfman disease is a
beningn and frequently overlooked clinical and pathological entity that may
be misinterpreted as a neoplastic disease.
Keywords: histiocytosis, sinus, diagnosis, differential, immunohistochemistry, treatment outcome
Projekat Ministarstva nauke
Republike Srbije, br. 41017