This work presents the generation and application of a process model which aims to increase the understanding of submerged entry nozzle (SEN) wear during continuous casting and its dependence on steel and slag compositions. An effective equilibrium reaction zone model was built and applied to calculate the equilibrium compositions of steel and slag at their common interface and in contact with the SEN. The results allow the estimation of the interface tension gradient responsible for Marangoni convection. Further, they include redox reactions at the slag/steel/refractory interface. Calculations were performed for a LC and a TRIP steel grade together with their respective mold fluxes. In both cases, the same SEN was used and the wear was assessed after service. In the case of the TRIP steel, the SEN showed by far lower wear and a less pronounced corrosion groove. The simulation showed that the interface tension difference responsible for Marangoni convection will be rather negligible for the case of TRIP steel, but it amounts to 150 mN/m for LC steel. Moreover, removal of carbon from the SEN zirconia-graphite sleeve will be caused by the reduction of silica in the slag. This is only possible at the three-phase boundary where the activity of the silicon formed is lowered by dissolution in the steel. Also, this effect is by far more distinct for LC steel and is in agreement with the different wear rate and corrosion groove. As a spin-off, the calculated interface tension might be interesting with respect to possible slag intrusion.