Path-dependent fatigue constitutive models for concrete tension, compression and rough crack shear are proposed and directly integrated with respect to time and deformational paths actualized in structural concrete. This approach is experimentally verified to be consistent with the fatigue life of materials and structural members under high repetition of forces. The mechanistic background of the extended truss model for fatigue design is also investigated. The coupling of fatigue loads with initial defects is simulated and its applicability is discussed as a versatile tool of performance assessment.