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Review

Advances in Halloysite Nanotubes–Polysaccharide Nanocomposite Preparation and Applications

by
Yang Wu
1,
Yongzhi Zhang
1,
Junping Ju
1,*,
Hao Yan
1,
Xiaoyu Huang
2 and
Yeqiang Tan
1,*
1
State Key Laboratory of Bio-fibers and Eco-textiles, Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, School of Materials Science and Engineering, Qingdao University, Qingdao 266071, China
2
Key Laboratory of Synthetic and Self-Assembly Chemistry for organic Functional Molecules, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
*
Authors to whom correspondence should be addressed.
Polymers 2019, 11(6), 987; https://doi.org/10.3390/polym11060987
Submission received: 18 April 2019 / Revised: 18 May 2019 / Accepted: 22 May 2019 / Published: 4 June 2019
(This article belongs to the Special Issue Polymer Clay Nano-composites)
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Abstract

:
Halloysite nanotubes (HNTs), novel 1D natural materials with a unique tubular nanostructure, large aspect ratio, biocompatibility, and high mechanical strength, are promising nanofillers to improve the properties of polymers. In this review, we summarize the recent progress toward the development of polysaccharide-HNTs composites, paying attention to the main existence forms and wastewater treatment application particularly. The purification of HNTs and fabrication of the composites are discussed first. Polysaccharides, such as alginate, chitosan, starch, and cellulose, reinforced with HNTs show improved mechanical, thermal, and swelling properties. Finally, we summarize the unique characteristics of polysaccharide-HNTs composites and review the recent development of the practical applications.

1. Introduction

Nanofillers recently have drawn extensive attention from academic and industrial fields due to their unique performance [1]. The traditional materials, such as black carbon, graphite, silica, and silicate, can significantly improve the mechanical properties, thermal stability, and permeability of various polymers [2,3]. Nowadays, clay mineral nanofillers with large aspect ratios, high strength, and relatively low density have attracted intense research interest [4]. Clay minerals, natural materials with proven biocompatibility and abundant storage, exhibit unique properties for various applications [5]. The majority of the research concerning clay minerals is devoted to kaolinite [6], montmorillonite [7], and illite [8]. In recent years, halloysite nanotubes (HNTs), 1D natural materials with a unique tubular nanostructure, large aspect ratio, biocompatibility, and high mechanical strength, have arisen as promising nanofillers to improve the properties of polymers [9,10].
Halloysite was first proposed by Berthier (1826) [11]. Raw halloysite, which is usually white, is exploited from natural sediments and is easily processed into powder. The sizes of halloysite depend on its specific geological deposit, as reported in the literature on the basis of microscopy [12] and scattering techniques [13]. It possesses several typical morphologies, such as spherical, sheet-like, and tubular particles due to the diversity of crystallization conditions and geological occurrence. Among them, the tubular structure is the most common and valuable [14]. The tubular structure is caused by lattice mismatch between adjacent silicone dioxide and aluminum oxide layers [15]. The molecular formula of HNTs is Al2Si2O5(OH)4·nH2O, where n represents hydration or dehydration. HNTs are hydrated when n equals 2 and are dehydrated when n equals 0 [16,17,18,19]. Compared with traditional nanofillers, such as carbon nanotubes (CNTs) [20] and boron nitride nanotubes (BNNTs) [21], HNTs have a prominent advantage, which is that they are far less expensive [22]. The length of HNTs ranges from 100 to 2000 nm, with the inner diameter from 10 to 30 nm and the outer diameter from 30 to 50 nm. In terms of functional groups, HNTs contain a large amount of hydroxyl groups situated between layers and on the surface, respectively. Due to the multi-layer structure, most of the hydroxyl groups are inner groups. In addition, the inner surfaces of the HNTs are positively charged, while the outer surfaces are negatively charged [12,23]. The detailed data of HNTs are listed in Table 1 [14,24].
Although the characteristics above generate excellent mechanical, thermal, and regenerable properties, the direct application of HNTs is limited. The drawbacks include difficulty in dissolving, brittleness, and low permeability [25]. With abundantly renewable sources and charming properties, including inherent biocompatibility, polysaccharides have attracted rising attention, and they have been widely applied to the medical [26], textile [27], and food fields, among others [28,29]. By preparing polysaccharide-HNTs composites, we can overcome these shortcomings. Due to the stable tubular morphology, charge distribution, the specific origin, and unique crystal structure, HNTs can be dispersed into single particles easily and the lumen diameter of HNTs fits well to macromolecule and protein diameters, causing the good combination between polysaccharides and HNTs [30,31,32]. The present research mainly focuses on alginate [33,34], chitosan [35], starch [36], cellulose [37], pectin, and carrageenan [38].
Although general properties of polysaccharide/halloysite nanotube composites and biomedical applications have been reviewed earlier by Liu et al. [39], we review the recent progress toward the development of polysaccharide-HNTs composites, paying attention to the main existence forms, wastewater treatment, and food packaging applications particularly. Through this review, we have a better understanding of unique characteristics of polysaccharide-HNTs composites, which can be helpful to the continuous expansion of their application in the future.

2. Preparation of Polysaccharide-HNTs Composites

2.1. Purification

Raw halloysite has impurities, such as quartz, illite, and perlite, since it is exploited directly from natural deposits. Therefore, the aggregate nanotubes should be separated to purify the HNTs before use in practical applications [40]. The traditional method of purification is the dispersion-centrifugation-drying technique. Firstly, we slowly added HNTs powder into deionized water under heating and mild stirring conditions. Then, the solution was further processed by lavation with deionized water three times and centrifugation. Finally, the pure HNTs were obtained after desiccation [41]. Figure 1 showed FE-SEM (Left) photos of HNTs and schematic illustration of crystalline structure (Right) of HNTs.

2.2. HNTs/Polysaccharide Preparations and Formulations

Using traditional processing techniques, HNTs can be mixed with most polysaccharides, such as alginate, chitosan, starch, cellulose, and carrageenan. The purpose of different fabrication methods is to enhance the interfacial interactions and dispersibility. In this section, we introduce the main existence forms of polysaccharide-HNTs composites.

2.2.1. Hydrogels

The hydrophilic structure of hydrogels enables them to hold large amounts of water in the three-dimensional networks. Due to the characteristics of high hygroscopicity and low stiffness, hydrogels are usually described as soft and wet materials [43,44]. Chan et al. prepared a HNTs/alginate hydrogel and the effects of HNTs on the physicochemical, thermal, mechanical, and mass transfer properties of alginate hydrogel beads were investigated in detail [45]. It was found that HNTs filled the interspace in the alginate matrix and allowed more efficient load transfer. The HNTs were embedded in the layers of alginate hydrogel networks and they had little effect on the size and on the shape of the alginate beads. The mechanism for enhanced mechanical strength could be attributed to physical interaction between the alginate and HNTs, and the mechanical strength could be improved at lower HNTs loading if chemical interactions were present. Zhou et al. reported alginate/HNTs composite hydrogels via solution mixing and subsequent cross-linking with calcium ions [46]. The static and shear viscosity of composite solutions increases with the increase of HNTs. The rheological behaviors of alginate/HNTs solutions were a shear thinning and fit with the power law model. Due to the good dispersion ability of HNTs, polysaccharides and HNTs are mixed easily via interfacial interactions, such as electrostatic and hydrogen bonding interactions, contributing to the formation of homogeneous composites and enhanced properties. Fourier-transform infrared spectroscopy (FTIR) and X-ray powder diffraction (XRD) are applied to study the interfacial interactions between alginate and HNTs. As shown in Figure 2b, the peaks at 1419 cm−1 shifted to higher wave numbers and no new peaks appeared in the composites, which indicated that hydrogen bond interactions occur between HNTs and alginate but no chemical reaction occurs. The XRD patterns of composites (Figure 2c) were very similar to HNTs no new diffraction peak occurring, which suggested the crystal structure of HNTs was retained in the composites.
The effect of HNTs on the swelling ratios of the polysaccharide/HNTs composites were investigated in NaCl and water solution. Compared with pure sodium alginate (SA) hydrogel, the SA/HNTs composite hydrogels showed low swelling ratios with the same conditions for soaking time, which gradually decreased with the increasing HNTs loading. This result was attributed to the hydrophilic polymer content in the composite hydrogels decreasing with the addition of HNTs, and the water adsorption of HNTs was lower than SA. In addition, the HNTs used as physical crosslinking points for alginate through the hydrogen bond interactions can greatly improve entanglement of the alginate and lower the mobility of the chains, resulting in water absorption being greatly decreased [47]. Sinem et al. reported a cryogenic technique to modify HNTs. The inner and outer diameters and the surface area of HNTs were evidently increased without disturbing the inherent tubular structure and wall features. Then, modified HNTs were mixed with chitosan to prepared composite hydrogels, showing remarkedly improved mechanical and swelling properties compared with pure chitosan hydrogel [48]. Sharifzadeh et al. synthesized carrageenan/HNTs nanocomposite hydrogels via physical crosslinking. The chemical structure confirmed by FTIR spectroscopy revealed the formation of physical interaction between carrageenan and HNTs in the hydrogels. It was revealed that the thermal stability and swelling of the nanocomposite hydrogels had significantly been improved due to the incorporation of HNTs compared with the pure carrageenan hydrogel [49]. The reasons why HNTs can improve the thermal stability of composites are as follows. The degradation temperature of HNTs is approximately 400 °C, which is higher than most of the polysaccharides. Then, the dispersed HNTs have a blocking effect on mass and heat transfer. Besides, the polysaccharide chains and degraded products enter the inner cavity of HNTs, delaying mass transport and improving the thermal stability. However, the good dispersion of HNTs into the hydrogel is urgently needed for the hydrogel fabrications to broaden their application. The HNTs functionalized via different types of silane coupling agents were used as a way to improve HNTs dispersal in the polymer matrix. Sabbagh et al. prepared novel chitosan/crosslinked oxidized starch hydrogels, which were embedded by modified or unmodified HNTs. Incorporation of HNTs significantly affected the swelling behavior and thermal properties of the hydrogel. The increase of the amine groups in HNTs modified with silane reagents made them react with oxidized starch, resulting in good dispersion in the structure of the hydrogel [50]. Figure 3 illustrates the formation of the bio-nanocomposite hydrogel.
The swelling ratio of the chitosan/HNTs hydrogel also decreased compared with the pure chitosan hydrogel, due to the introduction of HNTs content causing the chitosan to contract more [51]. The cellulose/HNTs composite showed a similar variation trend [52].

2.2.2. Films

Regenerated cellulose/HNTs nanocomposite films were fabricated in 1-butyl-3-methylimidazolium chloride ionic liquid by solution casting method. Figure 4 showed the cross-sectional FE-SEM images of the cellulose and 6 wt.% HNTs-filled nanocomposite films. The HNTs were well dispersed in cellulose due to good interaction between cellulose and HNTs. Young’s modulus and the tensile strength of nanocomposite films were improved by 100% and 55.3%, respectively, when the loading of HNTs was 6 wt.%, which was owing to tubular geometry and the higher stiffness of the HNTs. The addition of HNTs also improved the thermal stability and char yield of regenerated cellulose, but moisture absorption capacity of the nanocomposites in constant relative humidity was reduced due to the addition of HNTs [53].
Kim et al. reported transparent cellulose-obtained films from cellulose/HNTs solutions. The HNTs could uniformly been dispersed in cellulose because of the repulsive force from its surface charge, and the hydrogen bonding from HNTs and cellulose broke the chain-to-chain interactions of cellulose. The haze of the film was increased due to the introduction of HNTs but the diffuse transmittance could be retained [54].
Chang et al. prepared dispersed starch/HNTs composite films by using amylose to wrap the HNTs by ball-milling [55], in order to solve the agglomeration of HNTs. However, the extraction of amylose is expensive and complicated. In one work, polyethylene glycol (PEG) was used as a dispersing agent to mill, modify, and disperse HNTs in different solvents, and certain amounts of glycerin and modified HNTs suspension were added into the slurry. The composite films were obtained after stirring and casting on the stainless-steel plate. SEM of treated HNTs and HNTs/starch films with 3 wt.% (c and d) and 7 wt.% HNTs were shown in Figure 5. The HNTs are evenly distributed in the starch matrix. Due to the action of PEG, the treated HNTs were well dispersed in the starch matrix and the tensile strength of the film was effectively improved [56,57]. In another work, chitosan/starch/HNTs ternary nanocomposite films were developed through solution casting method. The interactions between chitosan, starch, and halloysite nanotubes were confirmed by FTIR results. Water absorption capacity, folding strength, and hemocompatibility were remarkedly enhanced owing to the addition of halloysite nanotubes [58]. Then, chitosan-HNTs composites were combined with modified cellulose to produce composite films using a solution casting method [59]; the excellent film formation and increase in surface roughness of the nanocomposite were confirmed by morphological and surface analysis. The kappa carrageenan/HNTs bio-nanocomposite films with enhanced tensile properties were successfully fabricated [60].
A functional bio-nanocomposite film both with antioxidant and antimicrobial active molecules was successfully prepared by the filling of a pectin matrix with modified HNTs containing peppermint oil. Importantly, the prepared functional film was considered a biocompatible material for packaging applications because of it was composed of eco-compatible molecules [61]. Makaremi et al. developed functional films with antimicrobial properties that can be extended over time by dispersing a HNTs/salicylic acid hybrid into the pectin matrix [62]. Moreover, it was demonstrated that the vacuum pumping in/out procedure can optimize the halloysite loading from the aqueous solution because of the water confinement mechanism [63]. Accordingly, the attained knowledge can offer new routes in the preparation of effective delivery systems based on HNTs.

2.2.3. Fibers

Fibers based on polysaccharides with high performance or special functions are becoming an emerging hotspot in both academic and industrial circles, exhibiting great potential in multiple fields.
HNTs can be well-dispersed in some ionic liquids. Song et al. firstly reported fabrication of microcrystalline cellulose/HNTs composite fibers from cellulose/ionic liquid/HNTs solutions by a wet-spinning method. Figure 6 showed schematic apparatus of nanocomposite fibers and SEM images of the morphology of fibers. The uniform dispersion of HNTs in the cellulose matrix was further confirmed by FTIR and wide-angle X-ray diffraction (WAXD) spectra. In addition, the homogeneous dispersion of HNTs and strong interfacial adhesion between HNTs and cellulose chains dramatically enhanced the moisture barrier property of cellulose fibers. Mechanical and thermal properties of HNTs nanocomposite fibers were greatly enhanced due to the uniform orientation of the well dispersed HNTs and great interactions from cellulose and HNTs caused by hydrogen bonding, van der Waals, and electrostatic interactions. For example, the tensile strength of the fibers increases from 73.8 to 130.1 MPa with the addition of HNTs from 0 to 7 wt.% [64].
Silva et al. developed HNTs reinforced alginate nanofibrous scaffolds fabricated by electrospinning. The diameter of alginate-based nanofibers ranged from 40 to 522 nm with well-aligned HNTs, as shown in Figure 7. The HNTs were well dispersed in the alginate matrix with good uniaxial alignment. Compared to the alginate-based scaffolds without HNTs, the tensile strength and elastic modulus of HNTs-reinforced nanofibrous scaffolds were significantly improved by 3-fold and 2-fold, respectively, when 5% (w/w) HNTs was added. The incorporation of HNTs also enhanced the thermal stability of the nanofibrous scaffolds [65].

2.2.4. Plasticized Nanocomposites

Plasticized halloysite nanocomposites are commonly prepared via solvent casting method, but this is limited in the practical processing industries. Thus, the melt mixing technique will be more efficient and productive in a process industry workshop [66].
Schmitt et al. successfully developed plasticized HNTs/wheat starch nanocomposites by melt-extrusion for the first time. A higher loading (up to 6 wt.%) of HNTs were well-dispersed in a starch matrix. The interactions between external hydroxyl groups of halloysites and C-O-C groups of starch were formed. The thermal stability of the matrix was improved with the addition of HNTs. The tensile strength and Young’s modulus of starch were improved up to 29% and 144%, respectively, without sacrificing ductility [67]. Porous plasticized starch/HNTs nanocomposites were also successfully prepared by melt-extrusion technique. Double benefits could be gained due to the addition of HNTs, which were as a nucleating agent increasing the porosity and as a barrier agent increasing the proportion of small cells [68]. Ren et al. reported plasticized starch/HNTs nanocomposites prepared by melt blending with different polyol plasticizers, such as glycerol, sorbitol, and a mixture of two. Compared to sorbitol or a mixture of two, glycerol offered a more uniform dispersion of HNTs in the starch matrix owing to more stable hydrogen bonds from glycerol and HNTs. The use of mixtures of these polyols was proved a promising way to optimize the mechanical properties of nanocomposites [69].

3. Applications of Polysaccharide-HNTs Composites

3.1. Biomedical Applications

Liu et al. summarized recent research progress in the biomedical application of polysaccharide-HNTs composites [39]. The interfacial interactions, structure, and properties of the composites were discussed in detail in that review. There were some examples in the biomedical applications, such as tissue engineering, wound healing, and drug carrier systems. Thus, we have listed some examples based on the previous work of Liu et al. in the following.

3.1.1. Drug Delivery and Release

HNTs were confirmed as potential drug and gene delivery vehicles [70,71], and the drug release rate slowed down by coating polysaccharides onto the drug-loaded HNTs. Recently, more and more attention has been paid to the drug sustained release based on the polysaccharide-HNTs composites [72,73].
Hydrogels have been researched for the controlled delivery of biomolecules, varying from small molecular weight drugs to biomacromolecules, such as nucleic acids, polysaccharides, and proteins. Moreover, the biocompatible and biodegradable hydrogels were prepared by different natural ingredients. Among them, the chitosan-HNTs composite hydrogels were widely researched due to their low toxicity, good biocompatibility, and degradability by human enzymes [74]. It was found that the chitosan-coated HNTs exhibited reduced release compared with the pure HNTs [24]. For instance, the chitosan-coated HNTs had released only 78% of the total drug payload, while the uncoated HNTs released 88% on day 9. The drug release rate was extremely low, and the residual content was under 10% of the loaded drug after 20 days. The reason why chitosan-coated HNTs have a lower drug release rate is the additional barrier through which the drug must diffuse provided by chitosan. In practical applications, chitosan-based hydrogels have been used for cancer therapeutics, subcutaneous release, and oral delivery. In recent years, the relevant relationship between plasticizer nature and drug release behavior has been exploited, so the starch/HNTs composite films have been prepared by melt blending technique for drug release applications [75]. In addition to drugs, other active agents, such as antimicrobial agents [76], DNA [77], and proteins, can also be loaded for controlled release.

3.1.2. Tissue Engineering Scaffold

Tissue engineering scaffolds are generally porous structures, biocompatible, and mechanically strong for shaping cell growth [78]. HNTs were added into polysaccharides, such as chitosan [79], alginate [47], and starch [68], to prepare various tissue engineering scaffolds. Compared with pristine chitosan, the chitosan-HNTs nanocomposite scaffolds showed an obvious improvement in mechanical strength, tensile modulus, and thermal stability. Moreover, the addition of HNTs had little influence on the pore structure of chitosan. Thus, the chitosan-HNTs exhibited a highly porous structure. In order to verify the feasibility of the nanocomposite scaffolds, mouse fibroblasts were used for culture. The result showed that mouse fibroblasts could develop on the chitosan-HNTs nanocomposite scaffold surfaces, even at 80 wt.% HNTs loading. In addition, the fibroblast cells cultured on the surfaces exhibited a phenotypic shape, indicating that the cells could penetrate and migrate within the scaffolds, which were similar to the extracellular matrix. Thus, polysaccharide-HNTs composites have promising potential in the tissue engineering scaffold field.

3.1.3. Wound Dressing

Wound dressings can be classified as traditional, biomaterial-based, interactive, and bioactive dressings. In recent research studies, biomaterials, such as polysaccharides, which are non-toxic, natural available, non-immunogenic, biocompatible, and biodegradable, have been considered as ideal materials for wound healing [80,81,82]. Due to the characteristics of biocompatibility, ability to load and release bioactive agents, high water content, and flexibility, hydrogels are most widely adopted for wound dressings [83]. Moreover, HNTs have been added into the polysaccharides, such as alginate [45,76] and chitosan [84,85], to overcome the poor mechanical strength of hydrogels. The alginate-HNTs wound dressing, based on a double barrier with the antibiotic vancomycin as an antimicrobial agent, was prepared. It was concluded that only the antibiotic vancomycin immobilized in HNTs- (3-Aminopropyl)-trimethoxysilane (APTS) and encapsulated in alginate hydrogels can be used as a wound dressing material.

3.2. Wastewater Treatment Applications

Among all the causes of wastewater pollutants, heavy metal ions, dyes, and other organic pollutants account for a large proportion [86]. Various methods, such as flocculation [87], precipitation [88], membrane filtration [89], and electrochemical techniques [90] have been restricted in practical usage because of the high cost, secondary pollutants, and poor removal efficiency. Due to its low cost, simple operation, and potential recycling and reuse, adsorption has become one of the most effective alternatives. Traditional absorbents, such as activated carbon [91] and resins [92], have been replaced by HNTs, a novel absorbent which is inexpensive and naturally abundant. In recent research studies, polysaccharide-HNTs composites exhibited promising adsorption capacity and regeneration.

3.2.1. Applications in Removal of Dyes

Pristine HNTs with the negative Si-O-Si on the outer surface and the positive Al-OH on the inner surface can adsorb both cationic and anionic dyes, but stable dispersions in water and reusability for its practical application are hard to obtain due to their size. Polysaccharides, such as chitosan, alginate, and starch, have been classified as natural biopolymer adsorbents, as they are non-toxic and biodegradable. However, polysaccharides materials usually have dense layer, low mechanical strength, and rigidity characteristics, which limits their application on a practical scale. Thus, polysaccharide-HNTs composites have been attractive due to combining their benefits for treatment of wastewater.
Cavallaro et al. prepared alginate/HNTs composite hydrogels by encapsulating HNTs into alginate hydrogels using the dropping technique. The adsorption capacity of composite hydrogels was investigated by removing crystal violet (CV) from aqueous media. The results showed that the addition of HNTs enhanced the composite hydrogel’s ability to capture CV. The weight ratio of alginate and HNTs was 2:1, and the removal rate was increased by 55% and 45%, respectively, when the stoichiometric adsorbent concentration increased from 0.25 to 0.50 mass% [93]. It was found that the pH and temperature had little influence on the adsorption capacity of alginate-HNTs composite beads. The alginate-HNTs composite adsorbents (10 g) had the ability to treat 29.7 L of 55 mg/L methylene blue (MB) solution and the removal efficiency was above 90%. Moreover, the column study verified that the removal efficiency had a slight decline with the increase of bed volumes, but it remained above 90% after 1500 bed volumes of wastewater was treated [94]. Novel chitosan-HNTs composite hydrogel beads were prepared by the dropping and pH-precipitation technique, exhibiting accelerated adsorption process and improved adsorption capacity (72.60 mg/g for MB and 276.9 mg/g for malachite green (MG)) compared with the pure chitosan bead. Similar to alginate-HNTs composites, chitosan-HNTs composites also exhibited excellent regeneration properties especially for MB (above 92%). The removal ratio of dyes increased but the adsorption amount per unit absorbent weight reduced with the addition of the composite hydrogels in solution [95]. The porous starch-HNTs composites were prepared by solvent exchange method using different drying methods. The adsorption performance depended on porosity, which was relative to specific surface area, and the size distribution of the pores and their area changed with different types of drying methods and percentage of ethanol. The adsorption capacity composites were improved due to the incorporation of HNTs [96]. A cryogenic technique to modify HNTs was confirmed to increase the inner and outer diameters and the surface area of HNTs without disturbing the inherent tubular structure and wall features. A small amount of cryo-expanded halloysite was used in chitosan. It was found that the composite hydrogel had a high adsorption capacity for anionic and cationic dyes [48].
Overall, polysaccharide-HNTs composites exhibit reinforced adsorption capacity and regeneration properties. Thus, polysaccharide-HNTs composites can be considered as promising reusable adsorbents for the removal of dyes from wastewater.

3.2.2. Applications in Removal of Heavy Metal Ions

HNTs with negatively charged surfaces were regarded as ideal alternatives for removal of heavy metal ions from aqueous media, such as Cu2+, Pb2+, and Cr2+ [14,97]. However, HNTs used as adsorbents face some problems in practical application due to their nanoscale size, such as being easily aggregated, being lost in use, the low permeability of packed adsorption columns, and being difficult to recycle. Thus, HNTs were combined with polysaccharides to improve the affinity and loading capacity for heavy metal ions. Extrusion dripping method was used to produce alginate-HNTs nanocomposite beads with calcium chloride as the curing agent. The results showed that the alginate-HNTs nanocomposite beads had improved adsorption capacity (325 mg/g at 0.2 g HNTs loading). It was also concluded that alginate and HNTs promoted the adsorption of Pb2+ by ion exchange and physisorption, respectively. It was simple to separate the used nanocomposite beads from wastewater by filtration due to the millimetric size, which facilitated the regeneration of the used beads [98]. In other works, the alginate-HNTs hybrid beads with high adsorption capacity for Cu2+ were prepared in the same way. The SEM image showed clearly that the HNTs overlapped loosely together in the interior of the hybrid beads, contributing to the mass transfer of the adsorbents. Furthermore, the regeneration experiment exhibited good adsorption efficiency (approximately 80%) after three cycles. In addition, the alginate-HNTs hybrid beads also showed good adsorption performance for other heavy metal ions, such as Ag+ and Cd2+ [99].
Compared to the traditional chemical methods of removing heavy metal ions from aqueous media, polysaccharide-HNTs composites had advantages, such as low cost, simple operation, regeneration, and being non-secondary pollutants.

3.3. Other Applications for Water Treatment

Currently, the research is focused on the applications of polysaccharide-HNTs composites for the removal of dyes and heavy metal ions in aqueous media. However, polysaccharide-HNTs composites have other practical applications for pollutants removal due to their unique structure and improved properties.
Different types of membranes, such as ultrafiltration, forward osmosis, reverse osmosis, and membrane reactors [100,101,102,103], were endowed with special performances by adopting HNTs. Cellulose acetate/L-dopa coated HNTs (LDPHNT) ultrafiltration membranes were prepared by blending in a casting solution. The Energy dispersive spectroscopy (EDS) analysis showed the uniform dispersion of LPDHNTs in the cellulose acetate (CA) membrane matrix. Moreover, the size and number of pores on the membrane surface were increased by the addition of LDPHNTs into CA solution. It was the existence of LDPHNTs that improved the hydrophilicity of the hybrid membranes. In the antifouling test, the composite membranes exhibited higher antifouling performance than pristine CA membranes. Besides, the tensile modulus and elongation at break point of LDPHNTs-CA hybrid membranes were reinforced compared to the pure CA membranes [104]. Some of the phenol-containing pesticides are widely used in agriculture and regarded as endocrine disruptors, exhibiting estrogenic activity and toxicity even at low concentrations. In order to remove phenol-containing pollutants, the special adsorbents based on HNTs were prepared. The chitosan-HNTs hybrid nanotubes were synthesized by simply assembling chitosan onto HNTs. Then, the horseradish peroxidase was immobilized on the hybrid nanotubes for the removal of phenol. The experiment showed that the immobilized HRP exhibited excellent removal efficiency for phenol from wastewater and the activity did not reduce the volume [25].

3.4. Food Packaging Applications

Over the years, polysaccharides, owing to their biodegradability, non-toxicity, and good film-forming ability, have raised concerns over their use as food packaging materials for consumer demand and environmental issues. However, these biodegradable polysaccharides have weak stability in processing, poor barrier properties, and high sensitivity to environmental changes. In the previous work, the introduction of HNTs nanoparticles to the starch matrix improved the mechanical properties and decreased permeability to water vapor and oxygen, water adsorption capacity, as well as the water solubility of the films [57], which gave them potential to be used for food packaging purposes. Makaremi et al. prepared biofilms composed of apple pectin and two different types of HNTs—MB with shorter tubes and lower surface area and PT with longer tubes and higher surface area—to obtain a novel functional bio-nanocomposite with enhanced mechanical and thermal properties. Moreover, both HNTs were employed as nanocontainers for salicylic acid, a well-known biocidal agent. On this basis, the HNTs/salicylic acid hybrids were dispersed into the apple pectin matrix to develop functional films with antimicrobial properties that can be extended over time. Thus, the bio-nanocomposite films showed promising potential for food packaging applications [62].
HNTs are able to adsorb active molecules, such as nisin and pediocin. On this basis, Meira et al. added peptides nisin and pediocin into starch films, resulting in active packaging materials with antimicrobial activity against L. monocytogenes and C. perfringens. The addition of HNTs enhanced the mechanical and thermal properties, especially when bacteriocins were adsorbed on the HNTs [105]. The moisture barrier properties of polysaccharide-based films are poor due to their hydrophilic characteristics. Essential oils with antioxidant and antimicrobial activities are commonly incorporated into polysaccharide matrices to overcome these limitations. However, it is rather hard to disperse the essential oils in a hydrophilic polysaccharide matrix. Lee et al. developed chitosan films incorporated with clove essential oil and HNTs. It was confirmed that the essential oils were stabilized by HNTs without any surfactant. The addition of HNTs into the chitosan matrix enhanced the mechanical and water barrier properties of the chitosan films, and the active molecule, clove essential oil, imparted antimicrobial and antioxidant effects to the chitosan-HNTs nanocomposite films. The results showed that the films inhibited growth of mold, which was derived from the surrounding environment. Therefore, the nanocomposite films could be used as active food packaging systems because of the antioxidant and antimicrobial properties and enhanced barrier properties against water vapor [106].

4. Conclusions

In this review, we summarized the recent research studies regarding polysaccharide-HNT composites. The key points of polysaccharide-HNTs composites are as follows:
(1)
HNTs, 1D natural nanoclays, have unique characteristics of tubular structure, high aspect ratio, abundant natural reserves, compatibility, and high mechanical strength. Due to the characteristics of HNTs, polysaccharide-HNTs composites have advantages, such as improved mechanical, thermal, and swelling properties and good biocompatibility. Thus, HNTs are promising nanofillers for high-performance polymer composites.
(2)
In addition to the characteristics of HNTs, the degree of dispersion of HNTs and the interfacial interactions between polysaccharides and HNTs (electrostatic and hydrogen bonding interactions) are crucial factors affecting the performance of composites.
(3)
HNTs can be combined with polysaccharides by different methods. Polysaccharide-HNTs composite hydrogels can be prepared by solution mixing and freeze-drying method and dropping or PH-precipitation technique; membranes are fabricated by solution casting method and fibers are usually produced by electrospinning technique. The key to this process is to obtain a well-dispersed solution with the HNTs and good interfacial interactions between polysaccharides and HNTs.
(4)
Polysaccharide-HNTs composites show promising potential for biomedical applications. The applications in removal of dyes and heavy metal ions are summarized in detail. Polysaccharide-HNTs composites have raised concerns as food packaging materials for consumer demand and environmental issues.

Author Contributions

Writing-original draft preparation, Y.W. and Y.Z.; Writing-review and editing, J.J. and Y.T.; Supervision, H.Y.; Project administration, X.H.; Conceptualization, Y.T.

Funding

This research received no external funding.

Acknowledgments

This work was supported by the National Nature Science Foundation of China (No. 51,403,113 and 51573080), Natural Science Foundation for Distinguished Young Scientists of Shan dong Province (BS2014CL007), Postdoctoral Science Foundation of China and Shandong Province (2016T90610, 2015M571994 and 201501007), Project of Shandong Province Higher Educational Science and Technology Program (J14LA19), and Program for Taishan Scholar of Shandong Province, Postdoctoral Science Foundation of Qingdao City (RZ1900002760), The Open Project Program of key Laboratory of Synthetic and Self-Assembly Chemistry for organic Functional Molecules (K2018-1), Research Project of Innovative Teaching Laboratory of Qingdao University, Shandong Provincial Natural Science Foundation (ZR2019YQ19).

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Moniruzzaman, M.; Winey, K.I. Polymer nanocomposites containing carbon nanotubes. Macromolecules 2006, 39, 5194–5205. [Google Scholar] [CrossRef]
  2. Tan, Y.Q.; Wang, L.B.; Xiao, J.L.; Zhang, X.; Wang, Y.; Liu, C.; Zhang, H.W.; Liu, C.Z.; Xia, Y.Z.; Sui, K.Y. Synchronous enhancement and stabilization of graphene oxide liquid crystals: Inductive effect of sodium alginates in different concentration zones. Polymer 2019, 160, 107–114. [Google Scholar] [CrossRef]
  3. Lvov, Y.; Abdullayev, E. Functional polymer-clay nanotube composites with sustained release of chemical agents. Prog. Polym. Sci. 2013, 38, 1690–1719. [Google Scholar] [CrossRef]
  4. Fakhrullina, G.I.; Akhatova, F.S.; Lvov, Y.M.; Fakhrullin, R.F. Toxicity of halloysite clay nanotubes in vivo: A Caenorhabditis elegans study. Environ. Sci. Nano 2015, 2, 54–59. [Google Scholar] [CrossRef]
  5. Lazzara, G.; Cavallaro, G.; Panchal, A.; Fakhrullin, R.; Stavitskaya, A.; Vinokurov, V.; Lvov, Y. An assembly of organic-inorganic composites using halloysite clay nanotubes. Curr. Opin. Colloid Interface Sci. 2018, 35, 42–50. [Google Scholar] [CrossRef]
  6. Mouni, L.; Belkhiri, L.; Bollinger, J.-C.; Bouzaza, A.; Assadi, A.; Tirri, A.; Dahmoune, F.; Madani, K.; Remini, H. Removal of Methylene Blue from aqueous solutions by adsorption on Kaolin: Kinetic and equilibrium studies. Appl. Clay Sci. 2018, 153, 38–45. [Google Scholar] [CrossRef]
  7. Zhu, R.; Chen, Q.; Zhou, Q.; Xi, Y.; Zhu, J.; He, H. Adsorbents based on montmorillonite for contaminant removal from water: A review. Appl. Clay Sci. 2016, 123, 239–258. [Google Scholar] [CrossRef] [Green Version]
  8. Hiranuma, N.; Augustin-Bauditz, S.; Bingemer, H.; Budke, C.; Curtius, J.; Danielczok, A.; Diehl, K.; Dreischmeier, K.; Ebert, M.; Frank, F.; et al. A comprehensive laboratory study on the immersion freezing behavior of illite NX particles: A comparison of 17 ice nucleation measurement techniques. Atmos. Chem. Phys. 2015, 15, 2489–2518. [Google Scholar] [CrossRef]
  9. Tully, J.; Yendluri, R.; Lvov, Y. Halloysite Clay Nanotubes for Enzyme Immobilization. Biomacromolecules 2016, 17, 615–621. [Google Scholar] [CrossRef]
  10. Lvov, Y.; Wang, W.; Zhang, L.; Fakhrullin, R. Halloysite Clay Nanotubes for Loading and Sustained Release of Functional Compounds. Adv. Mater. 2016, 28, 1227–1250. [Google Scholar] [CrossRef] [PubMed]
  11. Joussein, E.; Pettt, S.; Churchman, J.; Theng, B.; Righi, D.; Delvaux, B. Halloysite clay minerals—A review. Clay Min. 2005, 40, 383–426. [Google Scholar] [CrossRef]
  12. Pasbakhsh, P.; Churchman, G.J.; Keeling, J.L. Characterisation of properties of various halloysites relevant to their use as nanotubes and microfibre fillers. Appl. Clay Sci. 2013, 74, 47–57. [Google Scholar] [CrossRef]
  13. Cavallaro, G.; Chiappisi, L.; Pasbakhsh, P.; Gradzielski, M.; Lazzara, G. A structural comparison of halloysite nanotubes of different origin by Small-Angle Neutron Scattering (SANS) and Electric Birefringence. Appl. Clay Sci. 2018, 160, 71–80. [Google Scholar] [CrossRef]
  14. Du, M.; Guo, B.; Jia, D. Newly emerging applications of halloysite nanotubes: A review. Polym. Int. 2010, 25–36. [Google Scholar] [CrossRef]
  15. Vergaro, V.; Abdullayev, E.; Lvov, Y.M.; Zeitoun, A.; Cingolani, R.; Rinaldi, R.; Leporatti, S. Cytocompatibility and Uptake of Halloysite Clay Nanotubes. Biomacromolecules 2010, 11, 820–826. [Google Scholar] [CrossRef] [PubMed]
  16. Zhang, C.-L.; Cui, S.-J.; Wang, Y. Adsorption removal of pefloxacin from water by halloysite nanotubes. J. Ind. Eng. Chem. 2015, 23, 12–15. [Google Scholar] [CrossRef]
  17. Chen, Y.; Zhang, Y.; Zhang, H.; Liu, J.; Song, C. Biofouling control of halloysite nanotubes-decorated polyethersulfone ultrafiltration membrane modified with chitosan-silver nanoparticles. Chem. Eng. J. 2013, 228, 12–20. [Google Scholar] [CrossRef]
  18. Cataldo, S.; Lazzara, G.; Massaro, M.; Muratore, N.; Pettignano, A.; Riela, S. Functionalized halloysite nanotubes for enhanced removal of lead(II) ions from aqueous solutions. Appl. Clay Sci. 2018, 156, 87–95. [Google Scholar] [CrossRef]
  19. Abdullayev, E.; Lvov, Y. Halloysite Clay Nanotubes for Controlled Release of Protective Agents. J. Nanosci. Nanotechnol. 2011, 11, 10007–10026. [Google Scholar] [CrossRef] [PubMed]
  20. Yang, N.; Chen, X.; Ren, T.; Zhang, P.; Yang, D. Carbon nanotube based biosensors. Sens. Actuator B Chem. 2015, 207, 690–715. [Google Scholar] [CrossRef]
  21. Kalay, S.; Yilmaz, Z.; Sen, O.; Emanet, M.; Kazanc, E.; Culha, M. Synthesis of boron nitride nanotubes and their applications. Beilstein J. Nanotechnol. 2015, 6, 84–102. [Google Scholar] [CrossRef] [PubMed]
  22. Liu, R.; Zhang, B.; Mei, D.; Zhang, H.; Liu, J. Adsorption of methyl violet from aqueous solution by halloysite nanotubes. Desalination 2011, 268, 111–116. [Google Scholar] [CrossRef]
  23. Anastopoulos, I.; Mittal, A.; Usman, M.; Mittal, J.; Yu, G.; Núñez-Delgado, A.; Kornaros, M. A review on halloysite-based adsorbents to remove pollutants in water and wastewater. J. Mol. Liq. 2018, 269, 855–868. [Google Scholar] [CrossRef]
  24. Liu, M.; Jia, Z.; Jia, D.; Zhou, C. Recent advance in research on halloysite nanotubes-polymer nanocomposite. Prog. Polym. Sci. 2014, 39, 1498–1525. [Google Scholar] [CrossRef]
  25. Sun, X.; Zhang, Y.; Shen, H.; Jia, N. Direct electrochemistry and electrocatalysis of horseradish peroxidase based on halloysite nanotubes/chitosan nanocomposite film. Electrochim. Acta 2010, 56, 700–705. [Google Scholar] [CrossRef]
  26. Lee, K.Y.; Mooney, D.J. Alginate: Properties and biomedical applications. Prog. Polym. Sci. 2012, 37, 106–126. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  27. Aryee, A.N.A.; Agyei, D.; Akanbi, T.O. Recovery and utilization of seaweed pigments in food processing. Curr. Opin. Food Sci. 2018, 19, 113–119. [Google Scholar] [CrossRef]
  28. Galiano, F.; Briceño, K.; Marino, T.; Molino, A.; Christensen, K.V.; Figoli, A. Advances in biopolymer-based membrane preparation and applications. J. Membr. Sci. 2018, 564, 562–586. [Google Scholar] [CrossRef]
  29. Ma, Y.; Qi, P.; Ju, J.; Wang, Q.; Hao, L.; Wang, R.; Sui, K.; Tan, Y. Gelatin/alginate composite nanofiber membranes for effective and even adsorption of cationic dyes. Compos. Pt. B Eng. 2019, 162, 671–677. [Google Scholar] [CrossRef]
  30. Pasbakhsh, P.; De Silva, R.; Vahedi, V.; Jock Churchman, G. Halloysite nanotubes: Prospects and challenges of their use as additives and carriers -A focused review. Clay Min. 2018, 51, 479–487. [Google Scholar] [CrossRef]
  31. Kadam, A.A.; Jang, J.; Jee, S.C.; Sung, J.S.; Lee, D.S. Chitosan-functionalized supermagnetic halloysite nanotubes for covalent laccase immobilization. Carbohydr. Polym. 2018, 194, 208–216. [Google Scholar] [CrossRef]
  32. Lvov, Y.; Price, R.; Gaber, B.; Ichinose, I. Thin film nanofabrication via layer-by-layer adsorption of tubule halloysite, spherical silica, proteins and polycations. Colloid Surf. A Physicochem. Eng. Asp. 2002, 198, 375–382. [Google Scholar] [CrossRef]
  33. Venkatesan, J.; Bhatnagar, I.; Manivasagan, P.; Kang, K.-H.; Kim, S.-K. Alginate composites for bone tissue engineering: A review. Int. J. Biol. Macromol. 2015, 72, 269–281. [Google Scholar] [CrossRef] [PubMed]
  34. Wang, Q.; Ju, J.P.; Tan, Y.Q.; Hao, L.Y.; Ma, Y.L.; Wu, Y.; Zhang, H.W.; Xia, Y.Z.; Sui, K.Y. Controlled synthesis of sodium alginate electrospun nanofiber membranes for multi-occasion adsorption and separation of methylene blue. Carbohydr. Polym. 2019, 205, 125–134. [Google Scholar] [CrossRef] [PubMed]
  35. Ali, A.; Ahmed, S. A review on chitosan and its nanocomposites in drug delivery. Int. J. Biol. Macromol. 2018, 109, 273–286. [Google Scholar] [CrossRef] [PubMed]
  36. Hemamalini, T.; Dev, V.R.G. Comprehensive review on electrospinning of starch polymer for biomedical applications. Int. J. Biol. Macromol. 2018, 106, 712–718. [Google Scholar] [CrossRef]
  37. Nechyporchuk, O.; Belgacem, M.N.; Bras, J. Production of cellulose nanofibrils: A review of recent advances. Ind. Crop. Prod. 2016, 93, 2–25. [Google Scholar] [CrossRef]
  38. Necas, J.; Bartosikova, L. Carrageenan: A review. Vet. Med. 2013, 58, 187–205. [Google Scholar] [CrossRef]
  39. Liu, M.; He, R.; Yang, J.; Long, Z.; Huang, B.; Liu, Y.; Zhou, C. Polysaccharide-halloysite nanotube composites for biomedical applications: A review. Clay Min. 2018, 51, 457–467. [Google Scholar] [CrossRef]
  40. Shchukin, D.G.; Sukhorukov, G.B.; Price, R.R.; Lvov, Y.M. Halloysite nanotubes as biomimetic nanoreactors. Small 2005, 1, 510–513. [Google Scholar] [CrossRef]
  41. Qiu, K.; Netravali, A.N. Halloysite nanotube reinforced biodegradable nanocomposites using noncrosslinked and malonic acid crosslinked polyvinyl alcohol. Polym. Compos. 2013, 34, 799–809. [Google Scholar] [CrossRef]
  42. Yah, W.O.; Xu, H.; Soejima, H.; Ma, W.; Lvov, Y.; Takahara, A. Biomimetic Dopamine Derivative for Selective Polymer Modification of Halloysite Nanotube Lumen. J. Am. Chem. Soc. 2012, 134, 12134–12137. [Google Scholar] [CrossRef] [PubMed]
  43. Nie, J.Y.; Pei, B.Y.; Wang, Z.K.; Hu, Q.L. Construction of ordered structure in polysaccharide hydrogel: A review. Carbohydr. Polym. 2019, 205, 225–235. [Google Scholar] [CrossRef] [PubMed]
  44. Ahmed, E.M. Hydrogel: Preparation, characterization, and applications: A review. J. Adv. Res. 2015, 6, 105–121. [Google Scholar] [CrossRef] [PubMed]
  45. Chiew, C.S.C.; Poh, P.E.; Pasbakhsh, P.; Tey, B.T.; Yeoh, H.K.; Chan, E.S. Physicochemical characterization of halloysite/alginate bionanocomposite hydrogel. Appl. Clay Sci. 2014, 101, 444–454. [Google Scholar] [CrossRef]
  46. Huang, B.; Liu, M.; Long, Z.; Shen, Y.; Zhou, C. Effects of halloysite nanotubes on physical properties and cytocompatibility of alginate composite hydrogels. Mater. Sci. Eng. C Mater. Biol. Appl. 2017, 70, 303–310. [Google Scholar] [CrossRef]
  47. Liu, M.; Dai, L.; Shi, H.; Xiong, S.; Zhou, C. In vitro evaluation of alginate/halloysite nanotube composite scaffolds for tissue engineering. Mater. Sci. Eng. C Mater. Biol. Appl. 2015, 49, 700–712. [Google Scholar] [CrossRef]
  48. Palantoken, S.; Tekay, E.; Sen, S.; Nugay, T.; Nugay, N. A Novel Nonchemical Approach to the Expansion of Halloysite Nanotubes and Their Uses in Chitosan Composite Hydrogels for Broad-Spectrum Dye Adsorption Capacity. Polym. Compos. 2016, 37, 2770–2781. [Google Scholar] [CrossRef]
  49. Sharifzadeh, G.; Wahit, M.U.; Soheilmoghaddam, M.; Whye, W.T.; Pasbakhsh, P. Kappa-carrageenan/halloysite nanocomposite hydrogels as potential drug delivery systems. J. Taiwan Inst. Chem. Eng. 2016, 67, 426–434. [Google Scholar] [CrossRef]
  50. Sabbagh, N.; Akbari, A.; Arsalani, N.; Eftekhari-Sis, B.; Hamishekar, H. Halloysite-based hybrid bionanocomposite hydrogels as potential drug delivery systems. Appl. Clay Sci. 2017, 148, 48–55. [Google Scholar] [CrossRef]
  51. Huang, B.; Liu, M.; Zhou, C. Chitosan composite hydrogels reinforced with natural clay nanotubes. Carbohydr. Polym. 2017, 175, 689–698. [Google Scholar] [CrossRef] [PubMed]
  52. Huang, B.; Liu, M.X.; Zhou, C.R. Cellulose-halloysite nanotube composite hydrogels for curcumin delivery. Cellulose 2017, 24, 2861–2875. [Google Scholar] [CrossRef]
  53. Soheilmoghaddam, M.; Wahit, M.U.; Mahmoudian, S.; Hanid, N.A. Regenerated cellulose/halloysite nanotube nanocomposite films prepared with an ionic liquid. Mater. Chem. Phys. 2013, 141, 936–943. [Google Scholar] [CrossRef]
  54. Kim, Y.; Song, Y.; Kim, H. Preparation of transparent cellulose film with controlled haze using halloysite nanotubes. Cellulose 2018, 25, 1239–1248. [Google Scholar] [CrossRef]
  55. Chang, P.R.; Xie, Y.; Wu, D.; Ma, X. Amylose wrapped halloysite nanotubes. Carbohydr. Polym. 2011, 84, 1426–1429. [Google Scholar] [CrossRef]
  56. He, Y.; Kong, W.; Wang, W.; Liu, T.; Liu, Y.; Gong, Q.; Gao, J. Modified natural halloysite/potato starch composite films. Carbohydr. Polym. 2012, 87, 2706–2711. [Google Scholar] [CrossRef]
  57. Sadegh-Hassani, F.; Nafchi, A.M. Preparation and characterization of bionanocomposite films based on potato starch/halloysite nanoclay. Int. J. Biol. Macromol. 2014, 67, 458–462. [Google Scholar] [CrossRef] [PubMed]
  58. Devi, N.; Dutta, J. Development and in vitro characterization of chitosan/starch/halloysite nanotubes ternary nanocomposite films. Int. J. Biol. Macromol. 2019, 127, 222–231. [Google Scholar] [CrossRef] [PubMed]
  59. Cavallaro, G.; Lazzara, G.; Konnova, S.; Fakhrullin, R.; Lvov, Y. Composite films of natural clay nanotubes with cellulose and chitosan. Green Mater. 2014, 2, 232–242. [Google Scholar] [CrossRef]
  60. Wahab, I.F.; Abd Razak, S.I. Bionanocomposite fim of kappa-carrageenan/nanotube clay: Grrowth of hydroxyl apatite and model drug release. Dig. J. Nanomater. Biostruct. 2016, 11, 963–972. [Google Scholar]
  61. Biddeci, G.; Cavallaro, G.; Di Blasi, F.; Lazzara, G.; Massaro, M.; Milioto, S.; Parisi, F.; Riela, S.; Spinelli, G. Halloysite nanotubes loaded with peppermint essential oil as filler for functional biopolymer film. Carbohydr. Polym. 2016, 152, 548–557. [Google Scholar] [CrossRef] [PubMed]
  62. Makaremi, M.; Pasbakhsh, P.; Cavallaro, G.; Lazzara, G.; Aw, Y.K.; Lee, S.M.; Milioto, S. Effect of Morphology and Size of Halloysite Nanotubes on Functional Pectin Bionanocomposites for Food Packaging Applications. ACS Appl. Mater. Interfaces 2017, 9, 17476–17488. [Google Scholar] [CrossRef] [PubMed]
  63. Lisuzzo, L.; Cavallaro, G.; Pasbakhsh, P.; Milioto, S.; Lazzara, G. Why does vacuum drive to the loading of halloysite nanotubes? The key role of water confinement. J. Colloid Interface Sci. 2019, 547, 361–369. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  64. Luo, Z.; Wang, A.; Wang, C.; Qin, W.; Zhao, N.; Song, H.; Gao, J. Liquid crystalline phase behavior and fiber spinning of cellulose/ionic liquid/halloysite nanotubes dispersions. J. Mater. Chem. A 2014, 2, 7327–7336. [Google Scholar] [CrossRef]
  65. De Silva, R.T.; Dissanayake, R.K.; Mantilaka, M.; Wijesinghe, W.; Kaleel, S.S.; Premachandra, T.N.; Weerasinghe, L.; Amaratunga, G.A.J.; de Silva, K.M.N. Drug-Loaded Halloysite Nanotube-Reinforced Electrospun Alginate-Based Nanofibrous Scaffolds with Sustained Antimicrobial Protection. ACS Appl. Mater. Interfaces 2018, 10, 33913–33922. [Google Scholar] [CrossRef] [PubMed]
  66. Kausar, A. Review on Polymer/Halloysite Nanotube Nanocomposite. Polym. Plast. Technol. Eng. 2018, 57, 548–564. [Google Scholar] [CrossRef]
  67. Schmitt, H.; Prashantha, K.; Soulestin, J.; Lacrampe, M.F.; Krawczak, P. Preparation and properties of novel melt-blended halloysite nanotubes/wheat starch nanocomposites. Carbohydr. Polym. 2012, 89, 920–927. [Google Scholar] [CrossRef] [PubMed]
  68. Schmitt, H.; Creton, N.; Prashantha, K.; Soulestin, J.; Lacrampe, M.-F.; Krawczak, P. Preparation and Characterization of Plasticized Starch/Halloysite Porous Nanocomposites Possibly Suitable for Biomedical Applications. J. Appl. Polym. Sci. 2015, 132. [Google Scholar] [CrossRef]
  69. Ren, J.; Khanh Minh, D.; Pollet, E.; Averous, L. Preparation and Characterization of Thermoplastic Potato Starch/Halloysite Nano-Biocomposites: Effect of Plasticizer Nature and Nanoclay Content. Polymers 2018, 10, 808. [Google Scholar] [CrossRef] [PubMed]
  70. Aguzzi, C.; Viseras, C.; Cerezo, P.; Salcedo, I.; Sanchez-Espejo, R.; Valenzuela, C. Release kinetics of 5-aminosalicylic acid from halloysite. Colloid Surf. B Biointerfaces 2013, 105, 75–80. [Google Scholar] [CrossRef] [PubMed]
  71. Forsgren, J.; Jamstorp, E.; Bredenberg, S.; Engqvist, H.; Stromme, M. A Ceramic Drug Delivery Vehicle for Oral Administration of Highly Potent Opioids. J. Pharm. Sci. 2010, 99, 219–226. [Google Scholar] [CrossRef] [PubMed]
  72. Cavallaro, G.; Lazzara, G.; Milioto, S.; Parisi, F.; Evtugyn, V.; Rozhina, E.; Fakhrullin, R. Nanohydrogel Formation within the Halloysite Lumen for Triggered and Sustained Release. ACS Appl. Mater. Interfaces 2018, 10, 8265–8273. [Google Scholar] [CrossRef] [PubMed]
  73. Karnik, S.; Hines, K.; Mills, D.K. Nanoenhanced hydrogel system with sustained release capabilities. J. Biomed. Mater. Res. Part A 2015, 103, 2416–2426. [Google Scholar] [CrossRef] [PubMed]
  74. Bhattarai, N.; Gunn, J.; Zhang, M.Q. Chitosan-based hydrogels for controlled, localized drug delivery. Adv. Drug Deliv. Rev. 2010, 62, 83–99. [Google Scholar] [CrossRef] [PubMed]
  75. Ren, J.; Han, L.; Cai, H.; Wu, K.; Averous, L.; Guo, W. Functional Biocomposites Based on Plasticized Starch/halloysite Nanotubes for Drug-Release Applications. Starch-Starke 2018, 70, 1700358. [Google Scholar] [CrossRef]
  76. Kurczewska, J.; Pecyna, P.; Ratajczak, M.; Gajecka, M.; Schroeder, G. Halloysite nanotubes as carriers of vancomycin in alginate-based wound dressing. Saudi Pharm. J. 2017, 25, 911–920. [Google Scholar] [CrossRef]
  77. Shi, Y.-F.; Tian, Z.; Zhang, Y.; Shen, H.-B.; Jia, N.-Q. Functionalized halloysite nanotube-based carrier for intracellular delivery of antisense oligonucleotides. Nanoscale Res. Lett. 2011, 6, 1–7. [Google Scholar] [CrossRef]
  78. Del Buffa, S.; Rinaldi, E.; Carretti, E.; Ridi, F.; Bonini, M.; Baglioni, P. Injectable composites via functionalization of 1D nanoclays and biodegradable coupling with a polysaccharide hydrogel. Colloid Surf. B Biointerfaces 2016, 145, 562–566. [Google Scholar] [CrossRef]
  79. Liu, M.X.; Wu, C.C.; Jiao, Y.P.; Xiong, S.; Zhou, C.R. Chitosan-halloysite nanotubes nanocomposite scaffolds for tissue engineering. J. Mater. Chem. B 2013, 1, 2078–2089. [Google Scholar] [CrossRef]
  80. Dhivya, S.; Padma, V.V.; Santhini, E. Wound dressings—A review. BioMedicine 2015, 5, 24–28. [Google Scholar] [CrossRef]
  81. Ulery, B.D.; Nair, L.S.; Laurencin, C.T. Biomedical Applications of Biodegradable Polymers. J. Polym. Sci. Part B Polym. Phys. 2011, 49, 832–864. [Google Scholar] [CrossRef] [PubMed]
  82. Yadav, P.; Yadav, H.; Shah, V.G.; Shah, G.; Dhaka, G. Biomedical Biopolymers, their Origin and Evolution in Biomedical Sciences: A Systematic Review. J. Clin. Diac. Res. 2015, 9, ZE21–ZE25. [Google Scholar] [CrossRef] [PubMed]
  83. Sood, A.; Granick, M.S.; Tomaselli, N.L. Wound Dressings and Comparative Effectiveness Data. Adv. Wound Care 2014, 3, 511–529. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  84. Liu, M.; Shen, Y.; Ao, P.; Dai, L.; Liu, Z.; Zhou, C. The improvement of hemostatic and wound healing property of chitosan by halloysite nanotubes. RSC Adv. 2014, 4, 23540–23553. [Google Scholar] [CrossRef]
  85. Sandri, G.; Aguzzi, C.; Rossi, S.; Bonferoni, M.C.; Bruni, G.; Boselli, C.; Cornaglia, A.I.; Riva, F.; Viseras, C.; Caramella, C.; et al. Halloysite and chitosan oligosaccharide nanocomposite for wound healing. Acta Biomater. 2017, 57, 216–224. [Google Scholar] [CrossRef] [PubMed]
  86. Yu, L.; Wang, H.; Zhang, Y.; Zhang, B.; Liu, J. Recent advances in halloysite nanotube derived composites for water treatment. Environ. Sci. Nano 2016, 3, 28–44. [Google Scholar] [CrossRef]
  87. Teh, C.Y.; Budiman, P.M.; Shak, K.P.Y.; Wu, T.Y. Recent Advancement of Coagulation-Flocculation and Its Application in Wastewater Treatment. Ind. Eng. Chem. Res. 2016, 55, 4363–4389. [Google Scholar] [CrossRef]
  88. Thorat, A.A.; Dalvi, S.V. Liquid antisolvent precipitation and stabilization of nanoparticles of poorly water soluble drugs in aqueous suspensions: Recent developments and future perspective. Chem. Eng. J. 2012, 181, 1–34. [Google Scholar] [CrossRef]
  89. Leiknes, T. The effect of coupling coagulation and flocculation with membrane filtration in water treatment: A review. J. Environ. Sci. 2009, 21, 8–12. [Google Scholar] [CrossRef]
  90. Natarajan, R.; Al Fazari, F.; Al Saadi, A. Municipal waste water treatment by natural coagulant assisted electrochemical technique-Parametric effects. Environ. Technol. Innov. 2018, 10, 71–77. [Google Scholar] [CrossRef]
  91. Altenor, S.; Carene, B.; Emmanuel, E.; Lambert, J.; Ehrhardt, J.J.; Gaspard, S. Adsorption studies of methylene blue and phenol onto vetiver roots activated carbon prepared by chemical activation. J Hazard Mater. 2009, 165, 1029–1039. [Google Scholar] [CrossRef] [PubMed]
  92. Ozdemir, F.A.; Demirata, B.; Apak, R. Adsorptive removal of methylene blue from simulated dyeing wastewater with melamine-formaldehyde-urea resin. J. Appl. Polym. Sci. 2009, 112, 3442–3448. [Google Scholar] [CrossRef]
  93. Cavallaro, G.; Gianguzza, A.; Lazzara, G.; Milioto, S.; Piazzese, D. Alginate gel beads filled with halloysite nanotubes. Appl. Clay Sci. 2013, 72, 132–137. [Google Scholar] [CrossRef]
  94. Liu, L.; Wan, Y.; Xie, Y.; Zhai, R.; Zhang, B.; Liu, J. The removal of dye from aqueous solution using alginate-halloysite nanotube beads. Chem. Eng. J. 2012, 187, 210–216. [Google Scholar] [CrossRef]
  95. Peng, Q.; Liu, M.; Zheng, J.; Zhou, C. Adsorption of dyes in aqueous solutions by chitosan–halloysite nanotubes composite hydrogel beads. Microporous Mesoporous Mater. 2015, 201, 190–201. [Google Scholar] [CrossRef]
  96. Oliyaei, N.; Moosavi-Nasab, M.; Tamaddon, A.M.; Fazaeli, M. Preparation and characterization of porous starch reinforced with halloysite nanotube by solvent exchange method. Int. J. Biol. Macromol. 2019, 123, 682–690. [Google Scholar] [CrossRef]
  97. Wang, J.; Zhang, X.; Zhang, B.; Zhao, Y.; Zhai, R.; Liu, J.; Chen, R. Rapid adsorption of Cr (VI) on modified halloysite nanotubes. Desalination 2010, 259, 22–28. [Google Scholar]
  98. Chiew, C.S.C.; Yeoh, H.K.; Pasbakhsh, P.; Krishnaiah, K.; Poh, P.E.; Tey, B.T.; Chan, E.S. Halloysite/alginate nanocomposite beads: Kinetics, equilibrium and mechanism for lead adsorption. Appl. Clay Sci. 2016, 119, 301–310. [Google Scholar] [CrossRef]
  99. Wang, Y.; Zhang, X.; Wang, Q.; Zhang, B.; Liu, J. Continuous fixed bed adsorption of Cu(II) by halloysite nanotube-alginate hybrid beads: An experimental and modelling study. Water Sci Technol. 2014, 70, 192–199. [Google Scholar] [CrossRef]
  100. Yu, H.X.; Zhang, Y.T.; Sun, X.B.; Liu, J.D.; Zhang, H.Q. Improving the antifouling property of polyethersulfone ultrafiltration membrane by incorporation of dextran grafted halloysite nanotubes. Chem. Eng. J. 2014, 237, 322–328. [Google Scholar] [CrossRef]
  101. Ghanbari, M.; Emadzadeh, D.; Lau, W.J.; Lai, S.O.; Matsuura, T.; Ismail, A.F. Synthesis and characterization of novel thin film nanocomposite (TFN) membranes embedded with halloysite nanotubes (HNTs) for water desalination. Desalination 2015, 358, 33–41. [Google Scholar] [CrossRef]
  102. Ghanbari, M.; Emadzadeh, D.; Lau, W.J.; Matsuura, T.; Ismail, A.F. Synthesis and characterization of novel thin film nanocomposite reverse osmosis membranes with improved organic fouling properties for water desalination. RSC Adv. 2015, 5, 21268–21276. [Google Scholar] [CrossRef]
  103. Moslehyani, A.; Ismail, A.F.; Othman, M.H.D.; Matsuura, T. Hydrocarbon degradation and separation of bilge water via a novel TiO2-HNTs/PVDF-based photocatalytic membrane reactor (PMR). RSC Adv. 2015, 5, 14147–14155. [Google Scholar] [CrossRef]
  104. Mu, K.G.; Zhang, D.L.; Shao, Z.Q.; Qin, D.J.; Wang, Y.L.; Wang, S. Enhanced permeability and antifouling performance of cellulose acetate ultrafiltration membrane assisted by L-DOPA functionalized halloysite nanotubes. Carbohydr. Polym. 2017, 174, 688–696. [Google Scholar] [CrossRef] [PubMed]
  105. Meister Meira, S.M.; Zehetmeyer, G.; Werner, J.O.; Brandelli, A. A novel active packaging material based on starch-halloysite nanocomposites incorporating antimicrobial peptides. Food Hydrocoll. 2017, 63, 561–570. [Google Scholar] [CrossRef]
  106. Lee, M.H.; Kim, S.Y.; Park, H.J. Effect of halloysite nanoclay on the physical, mechanical, and antioxidant properties of chitosan films incorporated with clove essential oil. Food Hydrocoll. 2018, 84, 58–67. [Google Scholar] [CrossRef]
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Figure 1. FE-SEM Image of HNTs on Si-Wafer (Left) and Schematic Illustration of Crystalline Structure of HNTs (Right). (Reproduced from [42] with permission from American Chemical Society and Copyright Clearance Center, 2012).
Figure 1. FE-SEM Image of HNTs on Si-Wafer (Left) and Schematic Illustration of Crystalline Structure of HNTs (Right). (Reproduced from [42] with permission from American Chemical Society and Copyright Clearance Center, 2012).
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Figure 2. FTIR spectra (a,b) and XRD (c) pattern of HNTs, alginate, and alginate/HNTs composites. (Reproduced from [46] with permission from Elsevier and Copyright Clearance Center, 2017).
Figure 2. FTIR spectra (a,b) and XRD (c) pattern of HNTs, alginate, and alginate/HNTs composites. (Reproduced from [46] with permission from Elsevier and Copyright Clearance Center, 2017).
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Figure 3. Schematic description of bio-nanocomposite hydrogel formation. (Reproduced from [50] with permission from Elsevier and Copyright Clearance Center, 2017).
Figure 3. Schematic description of bio-nanocomposite hydrogel formation. (Reproduced from [50] with permission from Elsevier and Copyright Clearance Center, 2017).
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Figure 4. Cross-sectional FE-SEM images of cellulose and 6 wt.% HNTs filled cellulose/HNTs nanocomposite films under (a,b) low magnifications and (c) high magnification. (Reproduced from Reference [53] with permission from Elsevier and Copyright Clearance Center, 2013).
Figure 4. Cross-sectional FE-SEM images of cellulose and 6 wt.% HNTs filled cellulose/HNTs nanocomposite films under (a,b) low magnifications and (c) high magnification. (Reproduced from Reference [53] with permission from Elsevier and Copyright Clearance Center, 2013).
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Figure 5. SEM of treated halloysite (a,b) and halloysite/starch films with 3 wt.% (c,d) and 7 wt.% halloysite (e,f). (Reproduced from [56] with permission from Elsevier and Copyright Clearance Center, 2012).
Figure 5. SEM of treated halloysite (a,b) and halloysite/starch films with 3 wt.% (c,d) and 7 wt.% halloysite (e,f). (Reproduced from [56] with permission from Elsevier and Copyright Clearance Center, 2012).
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Figure 6. (a) Schematic apparatus for spinning MCC/HNTs nanocomposite fibers. (b) A 3 m long MCC/HNTs fiber wound on a plastic reel. (c,d) SEM images of the morphology of the side surface sections of regenerated MCC and MCC/HNTs fibers. (Reproduced from [64] with permission from Royal Society of Chemistry and Copyright Clearance Center, 2014).
Figure 6. (a) Schematic apparatus for spinning MCC/HNTs nanocomposite fibers. (b) A 3 m long MCC/HNTs fiber wound on a plastic reel. (c,d) SEM images of the morphology of the side surface sections of regenerated MCC and MCC/HNTs fibers. (Reproduced from [64] with permission from Royal Society of Chemistry and Copyright Clearance Center, 2014).
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Figure 7. Morphology of electrospun alginate-based scaffolds with (a) 0, (b,c) 5%, and (d) 10% (w/w) of HNTs. (Reproduced from [65] with permission from American Chemical Society and Copyright Clearance Center, 2018).
Figure 7. Morphology of electrospun alginate-based scaffolds with (a) 0, (b,c) 5%, and (d) 10% (w/w) of HNTs. (Reproduced from [65] with permission from American Chemical Society and Copyright Clearance Center, 2018).
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Table
Table 1. The detailed data of halloysite nanotubes (HNTs) related to combination with polysaccharides.
Table 1. The detailed data of halloysite nanotubes (HNTs) related to combination with polysaccharides.
Molecular FormulaAl2Si2O5(OH)4·nH2O
Length100–2000 nm
Inner diameter10–30 nm
Outer diameter30–50 nm
Aspect ratio (L/D)10–50
Young’s modulus of a single HNTs130 ± 24 GPa
Elastic modulus460 GPa
Interlayer water removal temperature400 °C
Water contact angle10 ± 3°
Specific surface area22.1–81.6 m2/g
Total pore volume0.06–0.25 cm3/g
Density2.14–2.59 g/cm3
Mean particle size in aqueous solution143 nm

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MDPI and ACS Style

Wu, Y.; Zhang, Y.; Ju, J.; Yan, H.; Huang, X.; Tan, Y. Advances in Halloysite Nanotubes–Polysaccharide Nanocomposite Preparation and Applications. Polymers 2019, 11, 987. https://doi.org/10.3390/polym11060987

AMA Style

Wu Y, Zhang Y, Ju J, Yan H, Huang X, Tan Y. Advances in Halloysite Nanotubes–Polysaccharide Nanocomposite Preparation and Applications. Polymers. 2019; 11(6):987. https://doi.org/10.3390/polym11060987

Chicago/Turabian Style

Wu, Yang, Yongzhi Zhang, Junping Ju, Hao Yan, Xiaoyu Huang, and Yeqiang Tan. 2019. "Advances in Halloysite Nanotubes–Polysaccharide Nanocomposite Preparation and Applications" Polymers 11, no. 6: 987. https://doi.org/10.3390/polym11060987

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