Abstract
Ginsenoside Rg3 and Rh2 possess various biological activities associated with Type 2 diabetes mellitus (T2DM). The insulin resistance of the muscle cells was induced by chronic insulin. The treatment of ginsenoside Rg3 and Rh2 significantly enhanced glucose uptake in the insulinresistant muscle cells and the relative abundance of AMP-activated protein kinase expression.
References
Attele AS, Wu JA, and Yuan CS (1999) Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 58, 1685–1693.
Choi K, Kim M, Ryu J, and Choi C (2007) Ginsenosides compound K and Rh(2) inhibit tumor necrosis factoralpha-induced activation of the NF-kappaB and JNK pathways in human astroglial cells. Neurosci Lett 421, 37–41.
Krook A, Wallberg-Henriksson H, and Zierath JR (2004) Sending the signal: molecular mechanisms regulating glucose uptake. Med Sci Sports Exerc 36, 1212–1217.
Kumar N and Dey CS (2002) Metformin enhances insulin signalling in insulin-dependent and-independent pathways in insulin resistant muscle cells. Br J Pharmacol 137, 329–336.
Kumar N and Dey CS (2003) Development of insulin resistance and reversal by thiazolidinediones in C2C12 skeletal muscle cells. Biochem Pharmacol 65, 249–257.
Liang Y and Zhao S (2008) Progress in understanding of ginsenoside biosynthesis. Plant Biol (Stuttg) 10, 415–421.
Oh JI, Chun KH, Joo SH, Oh YT, and Lee SK (2005) Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells. Cancer Lett 230, 228–238.
Park CE, Kim MJ, Lee JH, Min BI, Bae H, Choe W, Kim SS, and Ha J (2007) Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase. Exp Mol Med 39, 222–229.
Xie JT, Aung HH, Wu JA, Attel AS, and Yuan CS (2002a) Effects of american ginseng berry extract on blood glucose levels in ob/ob mice. Am J Chin Med 30, 187–194.
Xie JT, Zhou YP, Dey L, Attele AS, Wu JA, Gu M, Polonsky KS, and Yuan CS (2002b) Ginseng berry reduces blood glucose and body weight in db/db mice. Phytomedicine 9, 254–258.
Yin J, Gao Z, Liu D, Liu Z, and Ye J (2008) Berberine improves glucose metabolism through induction of glycolysis. Am J Physiol Endocrinol Metab 294, E148–156.
Yun TK (2003) Experimental and epidemiological evidence on non-organ specific cancer preventive effect of Korean ginseng and identification of active compounds. Mutat Res 523-524, 63–74.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lee, HM., Lee, OH. & Lee, BY. Effect of ginsenoside Rg3 and Rh2 on glucose uptake in insulin-resistant muscle cells. J. Korean Soc. Appl. Biol. Chem. 53, 106–109 (2010). https://doi.org/10.3839/jksabc.2010.018
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.3839/jksabc.2010.018