Accelerated Formation of Bone-Like Apatite on Biodegradable Polymer Substrates

Yi Zhi Chen; Arthur F.T. Mak; Min Wang

doi:10.4028/www.scientific.net/KEM.284-286.509

Paper Titles

Using X-Ray Micro-CT Imaging to Monitor Dissolution of Macroporous Bioactive Glass Scaffolds
p.493

Nanoscale Morphology of Apatite Precipitated onto Synthetic Hydroxyapatite from Simulated Body Fluid
p.497

A/W Bioactive Glass Particles in HEPES Solutions
p.501

Apatite Deposition on Polyamide Film Containing Silanol Groups in Simulated Body Environment
p.505

Accelerated Formation of Bone-Like Apatite on Biodegradable Polymer Substrates
p.509

Effect of Other Oxides on Solubility and Bioactivity in Calcium Phosphate Glasses
p.513

Conformational Change of Protein due to Contact with Bioceramic Materials
p.517

Activation of Hydroxyapatite Crystal Growth on the Surface of Biomimetic Synthetic Apatites through Electrical Polarization
p.521

Effect of Concentrated Sulfuric Acid-Etching on Apatite-Forming Ability of Alkaline-Treated Titanium
p.525

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Accelerated Formation of Bone-Like Apatite on Biodegradable Polymer Substrates

Abstract:

Using an acellular simulated body fluid (SBF), bone-like apatite can be formed on a variety of biomaterials, bioactive or bioinert, after these materials have undergone appropriate treatment(s). This biomimetic apatite-forming process is now applied to tissue engineering scaffolds in an attempt to make the scaffolds osteoconductive. In the current investigation, to form bone-like apatite on polymers such as poly(L-lactic acid) (PLLA) and poly(glycolic acid) (PGA) which degrade fast in aqueous environment, a solution (5SBF) of five times the ion concentrations of SBF was used so that an accelerated apatite formation could be achieved on PLLA and PGA. It was shown that indeed apatite could be formed on PLLA and PGA in 5SBF within 24 hours and that the apatite formed in 5SBF was similar in morphology and composition to that formed in the classical biomimetic process employing SBF or 2SBF. Results obtained in this investigation are very useful for producing osteoconductive scaffolds for bone tissue engineering.