Interest of High Shear Wet Granulation to Produce Drug Loaded Porous Calcium Phosphate Pellets for Bone Filling

Marylène Viana; Amelie Désiré; Emilie Chevalier; Eric Champion; Roxana Chotard-Ghodsnia; Dominique Chulia

doi:10.4028/www.scientific.net/KEM.396-398.535

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HomeKey Engineering MaterialsKey Engineering Materials Vols. 396-398Interest of High Shear Wet Granulation to Produce...

Interest of High Shear Wet Granulation to Produce Drug Loaded Porous Calcium Phosphate Pellets for Bone Filling

Abstract:

Spherical porous calcium phosphate pellets were fabricated by high shear wet granulation using native starch as a binder. After a heat treatment to eliminate the organic template, pellets were loaded with ibuprofen by solvent evaporation method. In vitro drug release kinetics was determined using an USP II apparatus (Prolabo Dissolution Tester, France). Results showed the interest of the calcination and of the increase in the binder-porogen content, to improve the drug loading (higher drug content) and prolong the release of the drug substance.

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Periodical:

Key Engineering Materials (Volumes 396-398)

Pages:

535-538

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.396-398.535

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Online since:

October 2008

Authors:

Marylène Viana, Amelie Désiré, Emilie Chevalier, Eric Champion, Roxana Chotard-Ghodsnia, Dominique Chulia

Keywords:

Bioceramic, Calcium Phosphate, Controlled-Release, Drug Delivery, Ibuprofen, In Vitro Dissolution, Porous Agent, Porous Pellets, Wet High Shear Granulation

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