Potent bioactive compounds from the ocean: some interesting aspects and applications

doi:10.5530/pj.2012.27.1

Pharmacognosy Journal

Volume 4, Issue 27, January–February 2012, Pages 1-5

https://doi.org/10.5530/pj.2012.27.1 Get rights and content

Abstract

Over seventy percent of the earth's surface is covered by oceans, and it is an established fact now, that life originated in the oceans. Additionally, the oceans are also the source of matchless natural products that are mainly accumulated in living organisms. Several bioactive compounds of therapeutic interest have been isolated from marine invertebrates, and some of them have been reported to be of microbial origin. Numerous of these compounds show pharmacological activities and are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, acquired immuno-deficiency syndrome, etc., while others have also been shown to possess several valuable properties. The secondary metabolites of microorganisms, algae and invertebrates, possess lifesaving properties, and are deadly toxins as well, depending on the dosage. The useful applications of these compounds, as bio-markers is also being explored, to further enrich pharmacological information. Recent developments have opened colossal areas of research for the isolation of biologically active compounds from marine flora and fauna.

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Effects of methanolic macroalgae extracts from Caulerpa sertularioides and Ulva lactuca on Litopenaeus vannamei survival in the presence of Vibrio bacteria
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Citation Excerpt :
More than 18,000 structurally unique bioactive metabolites have been isolated from plants and marine animals. Some of these compounds have been identified on the basis of their antibacterial, anti-inflammatory and anti-carcinogenic properties [7]. Macroalgae are potentially excellent sources of highly bioactive secondary metabolites that may be useful in the development of new functional ingredients.
Macroalgae are potentially excellent sources of highly bioactive secondary metabolites that are useful for the development of new functional ingredients. This study was conducted to determine whether methanolic extracts from Caulerpa sertularioides and Ulva lactuca macroalgae might be possible alternatives for the prevention of shrimp vibriosis, which is caused by Vibrio parahaemolyticus and Vibrio alginolyticus. Macroalgae extracts prepared with methanol as the solvent were evaluated for antibacterial activity with the microplate method. The extracts' effects on the mortality of juvenile Litopenaeus vannamei were evaluated at doses of 150 and 300 mg L⁻¹. Two independent assays for V. parahaemolyticus and V. alginolyticus were performed. The methanolic extract of C. sertularioides exhibited activity against V. parahaemolyticus and V. alginolyticus, and it had minimal inhibitory concentrations of <1000 and < 1500 μg mL⁻¹, respectively. L. vannamei mortality in the presence of both The methanolic extract of C. sertularioides exhibited activity against V. parahaemolyticus and V. alginolyticus, and it had minimal inhibitory concentrations of <1000 and <1500 μg mL⁻¹, respectively. and V. alginolyticus bacteria significantly decreased after treatment with 300 mg L⁻¹ C. sertularioides methanolic extract.
Effects of seaweeds extract on growth, survival, antibacterial activities, and immune responses of Penaeus monodon against Vibrio parahaemolyticus
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Inhibitory Effect on Biofilm Formation of Pathogenic Bacteria Induced by Rubrolide Lactam Analogues
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Marine anticancer drug research: An overview
2018, Advances in Science, Technology and Innovation

^a: Abbreviated name, as appears in several previous publications.

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Pharmacognosy Journal

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References (26)

Progress in the development and acquisition of anticancer agents from marine sources

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Halichondrins-antitumor polyether macrolides from a marine sponge

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Cited by (4)

Effects of methanolic macroalgae extracts from Caulerpa sertularioides and Ulva lactuca on Litopenaeus vannamei survival in the presence of Vibrio bacteria

Effects of seaweeds extract on growth, survival, antibacterial activities, and immune responses of Penaeus monodon against Vibrio parahaemolyticus

Inhibitory Effect on Biofilm Formation of Pathogenic Bacteria Induced by Rubrolide Lactam Analogues

Marine anticancer drug research: An overview