1999 | OriginalPaper | Buchkapitel
Mathematical Model of the Nucleic Acids Conformational Transitions with Hysteresis over Hydration—Dehydration Cycle
verfasst von : Michael Ye. Tolstorukov, Konstantin M. Virnik
Erschienen in: Computational Molecular Dynamics: Challenges, Methods, Ideas
Verlag: Springer Berlin Heidelberg
Enthalten in: Professional Book Archive
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A model of the conformational transitions of the nucleic acid molecule during the water adsorption-desorption cycle is proposed. The nucleic acid-water system is considered as an open system. The model describes the transitions between three main conformations of wet nucleic acid samples: A-, B- and unordered forms. The analysis of kinetic equations shows the non-trivial bifurcation behaviour of the system which leads to the multistability. This fact allows one to explain the hysteresis phenomena observed experimentally in the nucleic acid-water system. The problem of self-organization in the nucleic acid-water system is of great importance for revealing physical mechanisms of the functioning of nucleic acids and for many specific practical fields.