Skip to main content
Fachgebiete
Automobil + Motoren Bauwesen + Immobilien Business IT + Informatik Elektrotechnik + Elektronik Energie + Nachhaltigkeit Finance + Banking Management + Führung Marketing + Vertrieb Maschinenbau + Werkstoffe Versicherung + Risiko
DE
EN
Bücher
Zeitschriften
Themenseiten
Organisationspsychologie Projektmanagement Marketing Smart Manufacturing
Weitere Formate
Podcasts Webinare Technik Webinare Wirtschaft Kongresse Veranstaltungskalender Awards
Jetzt Einzelzugang starten
Zugang für Unternehmen
Referenzkunden
SLX-Digitalkonferenz: Zukunftswerkstatt 2024

Mehr Umsatz mit Top-Kontakten

Am 7. Mai erfahren Sie, wie Vertriebsteams Leadgenerierung, Leadnurturing und Leadstrategien effizient steuern können.
Erweiterte Suche
Anmelden
nach oben
Medical & Biological Engineering & Computing
Erschienen in: Medical & Biological Engineering & Computing 3/2018

09.08.2017 | Original Article

Mathematical modeling of extracorporeal CO2 removal therapy

A validation carried out on ten pigs

verfasst von: Simon Habran, Thomas Desaive, Philippe Morimont, Bernard Lambermont, Pierre Dauby

Erschienen in: Medical & Biological Engineering & Computing | Ausgabe 3/2018

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

The extracorporeal CO2 removal device (ECCO2RD) is used in clinics to treat patients suffering from respiratory failures like acute respiratory distress syndrome (ARDS) or chronic obstructive pulmonary disease (COPD). The aim of this device is to decarboxylate blood externally with low blood flow. A mathematical model is proposed to describe protective ventilation, ARDS, and an extracorporeal CO2 removal therapy (ECCO2RT). The simulations are compared with experimental data carried out on ten pigs. The results show a good agreement between the mathematical simulations and the experimental data, which provides a nice validation of the model. This model is thus able to predict the decrease of PCO2 during ECCO2RT for different blood flows across the extracorporeal lung support.
Vorheriger Artikel Image-based haptic roughness estimation and rendering for haptic palpation from in vivo skin image
Nächster Artikel Hemodynamic assessments of the ascending thoracic aortic aneurysm using fluid-structure interaction approach

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Jetzt informieren
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Abrams D, Roncon-Albuquerque R Jr, Brodie D (2015) What’s new in extracorporeal carbon dioxide removal for COPD? Intens Care Med 41(5):906CrossRef
2.
Anzueto A, Gattinoni L (2016) Prone position in ARDS. Acute Respir Distress Syndr 233:313
3.
Batzel JJ, Kappel F, Scneditz D, Tran HT (2007) Cardiovascular and respiratory systems: modeling, analysis, and control, vol 34. SIAM
4.
Bein T, Weber-Carstens S, Goldmann A, Müller T, Staudinger T, Brederlau J, Muellenbach R, Dembinski R, Graf BM, Wewalka M et al (2013) Lower tidal volume strategy (3 ml/kg) combined with extracorporeal CO2 removal versus “conventional” protective ventilation (6 ml/kg) in severe ARDS. Intens Care Med 39(5):847–856CrossRef
5.
6.
Brendle C, Hackmack KF, Kühn J, Wardeh M, Janisch T, Kopp R, Rossaint R, Stollenwerk A, Kowalewski S, Misgeld B et al (2017) Continuous gas transfer monitoring during extracorporeal membrane oxygenation. Biomed Signal Process Control 31:321–330CrossRef
7.
Burney PG, Patel J, Newson R, Minelli C, Naghavi M (2015) Global and regional trends in COPD mortality, 1990–2010. Euro Resp J 45(5):1239–1247CrossRef
8.
Enger TB, Philipp A, Videm V, Lubnow M, Wahba A, Fischer M, Schmid C, Bein T, Müller T (2014) Prediction of mortality in adult patients with severe acute lung failure receiving veno-venous extracorporeal membrane oxygenation: a prospective observational study. Crit Care 18(2):R67CrossRefPubMedPubMedCentral
9.
Fanelli V, Ranieri MV, Mancebo J, Moerer O, Quintel M, Morley S, Moran I, Parrilla F, Costamagna A, Gaudiosi M et al (2016) Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress syndrome. Crit Care 20 (1):36CrossRefPubMedPubMedCentral
10.
Ferguson N, Fan E, Camporota L, Antonelli M, Anzueto A, Beale R, Brochard L, Brower R, Esteban A, Gattinoni L, Rhodes A, Slutsky A, Vincent JL, Rubenfeld G, Thompson BT, Ranieri VM (2012) The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intens Care Med 38(10):1573–1582. doi:10.​1007/​s00134-012-2682-1 CrossRef
11.
Gnaiger E (1983) Calculation of energetic and biochemical equivalents of respiratory oxygen consumption. In: Polarographic oxygen sensors. Springer, pp 337–345
12.
Grodins FS, Buell J, Bart AJ (1967) Mathematical analysis and digital simulation of the respiratory control system. Tech. rep. DTIC Document
13.
Guyton CA, Hall EJ (2006) Textbook of medical physiology, 11th edn. Elsevier
14.
Hinski ST (2014) Respiratory care clinical competency lab manual (chapter 23). Elsevier Health Sciences
15.
Karagiannidis C, Kampe KA, Sipmann FS, Larsson A, Hedenstierna G, Windisch W, Mueller T (2014) Veno-venous extracorporeal CO2 removal for the treatment of severe respiratory acidosis: pathophysiological and technical considerations. Crit Care 18(3):R124CrossRefPubMedPubMedCentral
16.
17.
Karbing DS, Kjærgaard S, Smith BW, Allerød C, Espersen K, Andreassen S, Rees SE (2008) Decision support of inspired oxygen fraction using a model of oxygen transport. IFAC Proc 41(2):8080–8084CrossRef
18.
Klinzing S, Wenger U, Steiger P, Starck CT, Wilhelm M, Schuepbach RA, Maggiorini M (2015) External validation of scores proposed for estimation of survival probability of patients with severe adult respiratory distress syndrome undergoing extracorporeal membrane oxygenation therapy: a retrospective study. Crit Care 19 (1):142CrossRefPubMedPubMedCentral
19.
Linares OA, Schiesser WE, Fudin J, Pham TC, Bettinger JJ, Mathew RO, Daly AL (2015) In silico ordinary differential equation/partial differential equation hemodialysis model estimates methadone removal during dialysis. J Pain Res 8:417CrossRefPubMedPubMedCentral
20.
Messai E, Bouguerra A, Harmelin G, Di Lascio G, Bonizzoli M, Bonacchi M (2016) A numerical model of blood oxygenation during veno-venous ECMO: analysis of the interplay between blood oxygenation and its delivery parameters. J Clin Monitor Comput 30(3):327–332CrossRef
21.
Michael J, Murray DC (2008) Cardiopulmonary bypass: principles and practice (chapter 33). Lippincott Williams & Wilkins
22.
Misgeld BJE (2006) Automatic control of the heart-lung machine. Ruhr-Universität Bochum, Diss
23.
Morimont P, Batchinsky A, Lambermont B (2015) Update on the role of extracorporeal CO2 removal as an adjunct to mechanical ventilation in ards. Crit Care 19(1):1CrossRef
24.
Morimont P, Guiot J, Desaive T, Tchana-Sato V, Janssen N, Hella D, Blaffart F, Defraigne J, Lambermont B (2015) Veno-venous extracorporeal CO2 removal improves pulmonary hemodynamics in a porcine ARDS model. Acta Anaesthesiol Scand 59(4):448–456CrossRefPubMed
25.
Péronnet F., Massicotte D et al (1991) Table of nonprotein respiratory quotient: an update. Can J Sport Sci 16(1):23–29PubMed
26.
Pironet A, Dauby PC, Morimont P, Janssen N, Chase JG, Davidson S, Desaive T (2016) Model-based decision support algorithm to guide fluid resuscitation. IFAC-PapersOnLine 49(5):224–229CrossRef
27.
28.
29.
Rees SE, Kjærgaard S, Thorgaard P, Malczynski J, Toft E, Andreassen S (2002) The automatic lung parameter estimator (ALPE,) system: non-invasive estimation of pulmonary gas exchange parameters in 10-15 minutes. J Clin Monit Comput 17(1):43–52CrossRefPubMed
30.
Rees SE, Klæstrup E, Handy J, Andreassen S, Kristensen SR (2010) Mathematical modelling of the acid–base chemistry and oxygenation of blood: a mass balance, mass action approach including plasma and red blood cells. Eur J Appl Physiol 108(3):483–494CrossRefPubMed
31.
32.
Sklar MC, Beloncle F, Katsios CM, Brochard L, Friedrich JO (2015) Extracorporeal carbon dioxide removal in patients with chronic obstructive pulmonary disease: a systematic review. Intens Care Med 41 (10):1752–1762CrossRef
33.
Terragni P, Maiolo G, Ranieri VM (2012) Role and potentials of low-flow CO2 removal system in mechanical ventilation. Current Opin Crit Care 18(1):93–98CrossRef
34.
Thom TJ (1989) International comparisons in COPD mortality. Am Rev Respir Dis 140(3 Pt 2):S27–34CrossRefPubMed
35.
Trueb T, Cherniack N, D’souza A, Fishman A (1971) A mathematical model of the controlled plant of the respiratory system. Biophys J 11(10):810–834CrossRefPubMedPubMedCentral
36.
Walter M, Weyer S, Stollenwerk A, Kopp R, Arens J, Leonhardt S (2010) A physiological model for extracorporeal oxygenation controller design. Conf Proc IEEE Eng Med Biol Soc 1:434–437
37.
Metadaten
Titel
Mathematical modeling of extracorporeal CO2 removal therapy
A validation carried out on ten pigs
verfasst von
Simon Habran
Thomas Desaive
Philippe Morimont
Bernard Lambermont
Pierre Dauby
Publikationsdatum
09.08.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Medical & Biological Engineering & Computing / Ausgabe 3/2018
Print ISSN: 0140-0118
Elektronische ISSN: 1741-0444
DOI
https://doi.org/10.1007/s11517-017-1694-y

Weitere Artikel der Ausgabe 3/2018

Medical & Biological Engineering & Computing 3/2018 Zur Ausgabe

Original Article

The effects of paranodal myelin damage on action potential depend on axonal structure

Original Article

A piecewise function of resistivity of liver: determining parameters with finite element analysis of radiofrequency ablation

Original Article

A GPU-based symmetric non-rigid image registration method in human lung

Original Article

Sensitivity analysis of ventricular activation and electrocardiogram in tailored models of heart-failure patients

Original Article

Towards a patient-specific hepatic arterial modeling for microspheres distribution optimization in SIRT protocol

Original Article

Hemodynamic assessments of the ascending thoracic aortic aneurysm using fluid-structure interaction approach