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Erschienen in:
2017 | OriginalPaper | Buchkapitel
Mathematical Modelling of Drug Elution from Drug-Filled Stents
verfasst von : Tuoi T. N. Vo, Amy M. M. Collins, William T. Lee
Erschienen in: Progress in Industrial Mathematics at ECMI 2016
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Abstract
In this paper, we outline the first model to describe drug elution from a drug-filled stent. This novel polymer-free drug-eluting stent stores the therapeutic drug in the inner layer of a tri-layer wire. This inner layer acts a reservoir releasing the drug through laser-drilled holes on the outer surface of the stent struts. We simplify the general model using the assumption of low drug solubility and consider a special case where the dissolution occurs in a uniform downward direction. The main advantage of our simplified model is the ability to achieve analytical solutions. These solutions allow for calculating the drug release profile rapidly and for identifying the dependence of the various parameters of the system. We find that the duration of drug elution is prolonged when the solubility or diffusivity of the drug decreases.