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Erschienen in:
2011 | OriginalPaper | Buchkapitel
Measuring Shear Stress in Microfluidics using Traction Force Microscopy
verfasst von : Bryant Mueller
Erschienen in: Experimental and Applied Mechanics, Volume 6
Verlag: Springer New York
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Traction force microscopy is a previously-developed method to measure shear forces exerted by biological cells on substrates to which they are adhered (Dembo, 1999). The technique determines the shear stress applied on the surface of a soft polymeric substrate with known mechanical properties by measuring the displacement of micron-scale beads or pattered markers embedded in the surface. Marker displacement is monitored by capturing images of the embedded beads in the substrate when a load is applied. The surface shear stresses can then be calculated from the measured displacement and known elastic properties of the substrate.