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2013 | OriginalPaper | Buchkapitel

Mechanical and Chemical Regulation of Arterial and Venous Specification

verfasst von : Thomas N. Sato

Erschienen in: Mechanical and Chemical Signaling in Angiogenesis

Verlag: Springer Berlin Heidelberg

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Abstract

The fact that blood circulates through vessels was realized by William Harvey in the early seventeenth century. The blood flows away from the heart via arteries delivering oxygen and nutrients to peripheral organs and return to the heart via veins. Until late the 1990s, the distinction between artery and vein was recognized solely based on anatomical and function differences, basis, and it had been believed that arterial and venous specific characteristics are controlled by the respective hemodynamic forces that they are exposed to. However, in the past 15 years or so, it has become clear that they are also distinguished by the molecules that they express. Furthermore, their phenotypes are also regulated by genetic, hence, molecular (chemical), programs. In this chapter, I will summarize historical perspectives of the recognition of arteries and veins, and will review recent advance in our understating of mechanisms underlying arterial and venous specification mediated by mechanical and chemical signals. I conclude this chapter by proposing three models, morphogenetic, habituation, and integrative models, explaining how these two classes of signals become integrated to specify arteries and veins.

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Nächstes Kapitel Mechanosensory Pathways in Angiocrine Mediated Tissue Regeneration
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Metadaten
Titel
Mechanical and Chemical Regulation of Arterial and Venous Specification
verfasst von
Thomas N. Sato
Copyright-Jahr
2013
Verlag
Springer Berlin Heidelberg
Buch
Mechanical and Chemical Signaling in Angiogenesis

Print ISBN: 978-3-642-30855-0

Electronic ISBN: 978-3-642-30856-7

Copyright-Jahr: 2013

DOI
https://doi.org/10.1007/978-3-642-30856-7_1

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