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Erschienen in:
In Vivo, In Vitro, In Silico: Computational Tools for Product and Process Design in Tissue Engineering Kapitel lesen Erstes Kapitel lesen

2013 | OriginalPaper | Buchkapitel

Mechanobiological Modelling of Angiogenesis: Impact on Tissue Engineering and Bone Regeneration

verfasst von : Esther Reina-Romo, Clara Valero, Carlos Borau, Rafael Rey, Etelvina Javierre, María José Gómez-Benito, Jaime Domínguez, José Manuel García-Aznar

Erschienen in: Computational Modeling in Tissue Engineering

Verlag: Springer Berlin Heidelberg

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Abstract

Angiogenesis is essential for complex biological phenomena such as tissue engineering and bone repair. The ability to heal in these processes strongly depends on the ability of new blood vessels to grow. Capillary growth and its impact on human health has been focus of intense research from an in vivo, in vitro and in silico perspective. In fact, over the last decade many mathematical models have been proposed to understand and simulate the vascular network. This review addresses the role of the vascular network in well defined and controlled processes such as wound healing or distraction osteogenesis and covers the connection between vascularization and bone, starting with the biology of vascular ingrowth, moving through its impact on tissue engineering and bone regeneration, and ending with repair. Furthermore, we also describe the most recent in-silico models proposed to simulate the vascular network within bone constructs. Finally, discrete as well as continuum approaches are analyzed from a computational perspective and applied to three distinct phenomena: wound healing, distraction osteogenesis and individual cell migration in 3D.

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Vorheriges Kapitel Computational Mechanobiology in Cartilage and Bone Tissue Engineering: From Cell Phenotype to Tissue Structure
Nächstes Kapitel Mathematical Modelling of Regeneration of a Tissue-Engineered Trachea
Fußnoten
1
The authors apologize any related reference with the present work which remained uncited along the text.
 
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Metadaten
Titel
Mechanobiological Modelling of Angiogenesis: Impact on Tissue Engineering and Bone Regeneration
verfasst von
Esther Reina-Romo
Clara Valero
Carlos Borau
Rafael Rey
Etelvina Javierre
María José Gómez-Benito
Jaime Domínguez
José Manuel García-Aznar
Copyright-Jahr
2013
Verlag
Springer Berlin Heidelberg
Buch
Computational Modeling in Tissue Engineering

Print ISBN: 978-3-642-32562-5

Electronic ISBN: 978-3-642-32563-2

Copyright-Jahr: 2013

DOI
https://doi.org/10.1007/8415_2011_111

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