Tachykinins are rapidly metabolised by tissue preparations and their inactivation is believed to occur through hydrolysis by cell-surface ecto-peptidases . Enzymic and immunocytochemical studies in our laboratory have previously implicated endopeptidase-24.11 (‘ enkephalinase’, EC 188.8.131.52) in the metabolism of substance P [2–4]. The ability of pig striatal synaptic membranes to hydrolyse substance P was abolished by phosphoramidon and by an antiserum to the endopeptidase . Furthermore, substance P was the best substrate identified for the enzyme in vitro . We have also been able to demonstrate immunohistochemically the co-localisation of endopeptidase and substance P in specific brain regions, including globus pallidus and nucleus interpeduncular is . More recently, neurokinins A and B have also been shown to be good substrates for endopeptidase-24.11, implicating this enzyme in their metabolism [5,6].
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- Metabolism of Tachykinins by Cell-Surface Peptidases
A. J. Turner
N. M. Hooper
- Springer New York
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