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Erschienen in:
CMOS Nano-Pore Technology Kapitel lesen Erstes Kapitel lesen

2018 | OriginalPaper | Buchkapitel

5. Micro-NMR on CMOS for Biomolecular Sensing

verfasst von : Ka-Meng Lei, Nan Sun, Pui-In Mak, Rui Paulo Martins, Donhee Ham

Erschienen in: CMOS Circuits for Biological Sensing and Processing

Verlag: Springer International Publishing

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Abstract

In this chapter, we reported several portable nuclear magnetic resonance (NMR) systems implemented with silicon integrated circuits (IC). Being the initial researchers in the NMR on IC field, we firstly proposed to integrate the complex NMR electronics with the customized IC for portable NMR application with a palm size magnet. Moreover, to manage the samples inside the narrow opening of the portable magnet, we proposed the integration of the digital microfluidic device with the portable NMR system to attain electronic-automated multi-sample management scheme. With the capacitive sensing module of the droplets, the samples can be guided to the NMR sensing site sequentially to reduce labor and experimental time, which facilitates the detection and supports high-throughput sensing. Lastly, we demonstrates a NMR system with magnetic field calibration. This calibration culminates in a robust NMR sensing scheme by modulating the actual magnetic field to a steady value. Thus, the Larmor frequency can be stabilized, and the NMR sensing can work at different environment.

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Vorheriges Kapitel CMOS Multimodal Sensor Array for Biomedical Sensing
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Literatur
1.
M.A. Brown, R.C. Semelka, MRI: Basic Principles and Applications, 4th edn. (Wiley-Blackwell, 2010)
2.
D. Canet, Nuclear Magnetic Resonance: Concepts and Methods (Wiley, New York, 1996)
3.
H. Gunther, NMR Spectroscopy: Basic Principles, Concepts, and Applications in Chemistry (Weinheim, Germany, 1995)
4.
H. Lee, E. Sun, D. Ham, R. Weissleder, Chip-NMR biosensor for detection and molecular analysis of cells. Nat. Med. 14(8), 869–874 (2008)CrossRef
5.
J.M. Perez, L. Josephson, T. O’Loughlin, D. Hogemann, R. Weissleder, Magnetic relaxation switches capable of sensing molecular interactions. Nat. Biotechnol. 20(8), 816–820 (2002)CrossRef
6.
J.A. Slichter, Principles of Magnetic Resonance (Springer, Heidelberg, 1990)CrossRef
7.
K.-M. Lei, H. Heidari, P.-I. Mak, M.-K. Law, F. Maloberti, R.P. Martins, A handheld high-sensitivity micro-NMR CMOS platform with B-field stabilization for multi-type biological/chemical assays. IEEE J. Solid State Circuits 52(1), 284–297 (2017)CrossRef
8.
K.-M. Lei, H. Heidari, P.-I. Mak, M.-K. Law, F. Maloberti, R.P. Martins, A handheld 50pM-sensitivity micro-NMR CMOS platform with B-field stabilization for multi-type biological/chemical assays, in 2016 IEEE International Solid-State Circuits Conference (ISSCC) (2016b), pp. 474–475, Feb 2016
9.
K.-M. Lei, P.-I. Mak, M.-K. Law, R.P. Martins, A μNMR CMOS transceiver using a butterfly-coil input for integration with a digital microfluidic device inside a portable magnet. IEEE J. Solid State Circuits 51(10), 2274–2286 (2016c)CrossRef
10.
K.-M. Lei, P.-I. Mak, M.-K. Law, R.P. Martins, A palm-size μNMR relaxometer using a digital microfluidic device and a semiconductor transceiver for chemical/biological diagnosis. Analyst 140(15), 5129–5137 (2015b)CrossRef
11.
K.-M. Lei, P.-I. Mak, M.-K. Law, R.P. Martins, A μNMR CMOS transceiver using a butterfly-coil input for integration with a digital microfluidic device inside a portable magnet, in 2015 IEEE Asian Solid-State Circuits Conference (A-SSCC) (2015c), pp. 1–4, 9–11 Nov 2015
12.
Y. Liu, N. Sun, H. Lee, R. Weissleder, D. Ham, CMOS mini nuclear magnetic resonance system and its application for biomolecular sensing, in 2008 IEEE International Solid-State Circuits Conference (ISSCC) (2008), pp. 140–602, 3–7 Feb 2008
13.
N. Sun, T.J. Yoon, H. Lee, W. Andress, R. Weissleder, D. Ham, Palm NMR and 1-Chip NMR. IEEE J. Solid State Circuits 46(1), 342–352 (2011)CrossRef
14.
N. Sun, T.J. Yoon, H. Lee, W. Andress, V. Demas, P. Prado, R. Weissleder, D. Ham, Palm NMR and one-chip NMR, in 2010 IEEE International Solid-State Circuits Conference – (ISSCC) (2010), pp. 488–489, 7–11 Feb 2010
15.
N. Sun, Y. Liu, H. Lee, R. Weissleder, D. Ham, CMOS RF biosensor utilizing nuclear magnetic resonance. IEEE J. Solid State Circuits 44(5), 1629–1643 (2009)CrossRef
16.
D. Ham, A. Hajimiri, Virtual damping and Einstein relation in oscillators. IEEE J. Solid State Circuits 38(3), 407–418 (2003)CrossRef
17.
X. Li, W. Zhu, D. Ham, Phase diffusion and lamb-shift-like spectrum shift in classical oscillators. (2010a). arXiv:0908.2214v3
18.
X.F. Li, O.O. Yildirim, W.J. Zhu, D. Ham, Phase noise of distributed oscillators. IEEE Trans. Microwave Theory Tech. 58(8), 2105–2117 (2010b)CrossRef
19.
D.I. Hoult, R.E. Richards, The signal-to-noise ratio of the nuclear magnetic resonance experiment. J. Magn. Reson. 24(1), 71–85 (1976)
20.
R. Gruetter, Automatic, localized in vivo adjustment of all 1st-order and 2nd-order shim coils. Magn. Reson. Med. 29(6), 804–811 (1993)CrossRef
21.
E. Danieli, J. Perlo, B. Blumich, F. Casanova, Small magnets for portable NMR spectrometers. Angew. Chem. Int. Ed. 49(24), 4133–4135 (2010)CrossRef
22.
E. Danieli, J. Perlo, F. Casanova, B. Blümich, High-performance shimming with permanent magnets, in Magnetic Resonance Microscopy, 1st edn., (Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2009a), pp. 485–499
23.
E. Danieli, J. Mauler, J. Perlo, B. Blumich, F. Casanova, Mobile sensor for high resolution NMR spectroscopy and imaging. J. Magn. Reson. 198(1), 80–87 (2009b)CrossRef
24.
H.Y. Carr, E.M. Purcell, Effects of diffusion on free precession in nuclear magnetic resonance experiments. Phys. Rev. 94(3), 630–638 (1954)CrossRef
25.
S. Meiboom, D. Gill, Modified spin-echo method for measuring nuclear relaxation times. Rev. Sci. Instrum. 29(8), 688–691 (1958)CrossRef
26.
B. Behnia, A.G. Webb, Limited-sample NMR using solenoidal microcoils perfluouocarbon plugs, and capillary spinning. Anal. Chem. 70(24), 5326–5331 (1998)CrossRef
27.
D.L. Olson, T.L. Peck, A.G. Webb, R.L. Magin, J.V. Sweedler, High-resolution microcoil 1H-NMR for mass-limited, nanoliter-volume samples. Science 270(5244), 1967–1970 (1995)CrossRef
28.
F.D. Doty, Probe design and construction, in Encyclopedia of Magnetic Resonance, (Wiley, New York, 2007)
29.
A.P.M. Kentgens, J. Bart, P.J.M. van Bentum, A. Brinkmann, E.R.H. Van Eck, J.G.E. Gardeniers, J.W.G. Janssen, P. Knijn, S. Vasa, M.H.W. Verkuijlen, High-resolution liquid- and solid-state nuclear magnetic resonance of nanoliter sample volumes using microcoil detectors. J. Chem. Phys. 128(5) (2008)
30.
K.R. Minard, R.A. Wind, Solenoidal microcoil design – part II: optimizing winding parameters for maximum signal-to-noise performance. Concepts Magn. Reson. 13(3), 190–210 (2001a)CrossRef
31.
K.R. Minard, R.A. Wind, Solenoidal microcoil design. Part I: optimizing RF homogeneity and coil dimensions. Concepts Magn. Reson. 13(2), 128–142 (2001b)CrossRef
32.
R.M. Fratila, A.H. Velders, Small-volume nuclear magnetic resonance spectroscopy. Annu. Rev. Anal. Chem. 4(1), 227–249 (2011)CrossRef
33.
C.J. Jones, C.K. Larive, Could smaller really be better? Current and future trends in high-resolution microcoil NMR spectroscopy. Anal. Bioanal. Chem. 402(1), 61–68 (2012)CrossRef
34.
C. Massin, F. Vincent, A. Homsy, K. Ehrmann, G. Boero, P.A. Besse, A. Daridon, E. Verpoorte, N.F. de Rooij, R.S. Popovic, Planar microcoil-based microfluidic NMR probes. J. Magn. Reson. 164(2), 242–255 (2003)CrossRef
35.
C. Massin, C. Azevedo, N. Beckmann, P.A. Besse, R.S. Popovic, Magnetic resonance imaging using microfabricated planar coils, in 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology (2002), pp. 199–204
36.
C. Massin, A. Daridon, F. Vincent, G. Boero, P.-A. Besse, E. Verpoorte, N.F. de Rooij, R.S. Popovic, A microfabricated probe with integrated coils and channels for on-chip NMR spectroscopy, in Micro Total Analysis Systems 2001: Proceedings of the μTAS 2001 Symposium, Held in Monterey, 1st edn., ed. by J. M. Ramsey, A. van den Berg (Springer, Dordrecht, 2001), pp. 438–440, 21–25 Oct 2001
37.
H. Ryan, S.H. Song, A. Zass, J. Korvink, M. Utz, Contactless NMR spectroscopy on a chip. Anal. Chem. 84(8), 3696–3702 (2012)CrossRef
38.
J. Anders, G. Chiaramonte, P. SanGiorgio, G. Boero, A single-chip array of NMR receivers. J. Magn. Reson. 201(2), 239–249 (2009)CrossRef
39.
V. Badilita, K. Kratt, N. Baxan, J. Anders, D. Elverfeldt, G. Boero, J. Hennig, J.G. Korvink, U. Wallrabe, 3D solenoidal microcoil arrays with CMOS integrated amplifiers for parallel MR imaging and spectroscopy, in 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems (2011), pp. 809–812, 23–27 Jan 2011
40.
D.I. Hoult, The NMR receiver: a description and analysis of design. Prog. Nucl. Magn. Reson. Spectrosc. 12(1), 41–77 (1978)CrossRef
41.
H. Lee, T.J. Yoon, J.L. Figueiredo, F.K. Swirski, R. Weissleder, Rapid detection and profiling of cancer cells in fine-needle aspirates. Proc. Natl. Acad. Sci. 106(30), 12459–12464 (2009)CrossRef
42.
J.D. Trumbull, I.K. Glasgow, D.J. Beebe, R.L. Magin, Integrating microfabricated fluidic systems and NMR spectroscopy. I.E.E.E. Trans. Biomed. Eng. 47(1), 3–7 (2000)CrossRef
43.
I. Barbulovic-Nad, H. Yang, P.S. Park, A.R. Wheeler, Digital microfluidics for cell-based assays. Lab Chip 8(4), 519–526 (2008)CrossRef
44.
J. Gao, X.M. Liu, T.L. Chen, P.I. Mak, Y.G. Du, M.I. Vai, B.C. Lin, R.P. Martins, An intelligent digital microfluidic system with fuzzy-enhanced feedback for multi-droplet manipulation. Lab Chip 13(3), 443–451 (2013)CrossRef
45.
F. Lapierre, M. Harnois, Y. Coffinier, R. Boukherroub, V. Thomy, Split and flow: reconfigurable capillary connection for digital microfluidic devices. Lab Chip 14(18), 3589–3593 (2014)CrossRef
46.
M.G. Pollack, A.D. Shenderov, R.B. Fair, Electrowetting-based actuation of droplets for integrated microfluidics. Lab Chip 2(2), 96–101 (2002)CrossRef
47.
M.H. Shamsi, K. Choi, A.H.C. Ng, A.R. Wheeler, A digital microfluidic electrochemical immunoassay. Lab Chip 14(3), 547–554 (2014)CrossRef
48.
V. Srinivasan, V.K. Pamula, R.B. Fair, An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids. Lab Chip 4(4), 310–315 (2004)CrossRef
49.
A.R. Wheeler, Chemistry – putting electrowetting to work. Science 322(5901), 539–540 (2008)CrossRef
50.
I. Barbulovic-Nad, S.H. Au, A.R. Wheeler, A microfluidic platform for complete mammalian cell culture. Lab Chip 10(12), 1536–1542 (2010)CrossRef
51.
G.J. Shah, A.T. Ohta, E.P.Y. Chiou, M.C. Wu, C.-J. Kim, EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis. Lab Chip 9(12), 1732–1739 (2009)CrossRef
52.
Y.-H. Chang, G.-B. Lee, F.-C. Huang, Y.-Y. Chen, J.-L. Lin, Integrated polymerase chain reaction chips utilizing digital microfluidics. Biomed. Microdevices 8(3), 215–225 (2006)CrossRef
53.
Z. Hua, J.L. Rouse, A.E. Eckhardt, V. Srinivasan, V.K. Pamula, W.A. Schell, J.L. Benton, T.G. Mitchell, M.G. Pollack, Multiplexed real-time polymerase chain reaction on a digital microfluidic platform. Anal. Chem. 82(6), 2310–2316 (2010)CrossRef
54.
R. Sista, Z. Hua, P. Thwar, A. Sudarsan, V. Srinivasan, A. Eckhardt, M. Pollack, V. Pamula, Development of a digital microfluidic platform for point of care testing. Lab Chip 8(12), 2091–2104 (2008)CrossRef
55.
D. Witters, K. Knez, F. Ceyssens, R. Puers, J. Lammertyn, Digital microfluidics-enabled single-molecule detection by printing and sealing single magnetic beads in femtoliter droplets. Lab Chip 13(11), 2047–2054 (2013)CrossRef
56.
P. Andreani, K. Kozmin, P. Sandrup, M. Nilsson, T. Mattsson, A TX VCO for WCDMA/EDGE in 90 nm RF CMOS. IEEE J. Solid State Circuits 46(7), 1618–1626 (2011)CrossRef
57.
T. Mattsson, Method of and inductor layout for reduced VCO coupling. U.S. Patent 7,151,430, 19 Dec 2006
58.
M. Nagata, H. Masuoka, S.I. Fukase, M. Kikuta, M. Morita, N. Itoh, 5.8 GHz RF transceiver LSI including on-chip matching circuits, in Bipolar/BiCMOS Circuits and Technology Meeting (2006), pp. 263–266, Oct 2006
59.
F. Mugele, J.C. Baret, Electrowetting: from basics to applications. J. Phys. Condens. Matter 17(28), R705–R774 (2005)CrossRef
60.
J. Gong, C.J. Kim, All-electronic droplet generation on-chip with real-time feedback control for EWOD digital microfluidics. Lab Chip 8(6), 898–906 (2008)CrossRef
61.
W.K. Peng, L. Chen, J. Han, Development of miniaturized, portable magnetic resonance relaxometry system for point-of-care medical diagnosis. Rev. Sci. Instrum. 83(9) (2012)
62.
J.M. Pope, N. Repin, A simple approach to T2 imaging in MRI. Magn. Reson. Imaging 6(6), 641–646 (1988)CrossRef
63.
D. Ha, J. Paulsen, N. Sun, Y.Q. Song, D. Ham, Scalable NMR spectroscopy with semiconductor chips. Proc. Natl. Acad. Sci. 111(33), 11955–11960 (2014)CrossRef
64.
E. Kupce, R. Freeman, Molecular structure from a single NMR sequence (fast-PANACEA). J. Magn. Reson. 206(1), 147–153 (2010)CrossRef
65.
G.A. Morris, H. Barjat, T.J. Horne, Reference deconvolution methods. Prog. Nucl. Magn. Reson. Spectrosc. 31(1), 197–257 (1997)CrossRef
66.
H. Heidari, E. Bonizzoni, U. Gatti, F. Maloberti, A CMOS current-mode magnetic hall sensor with integrated front-end. IEEE Trans. Circuits Syst. I Regul. Pap. 62(5), 1270–1278 (2015)MathSciNetCrossRef
67.
J. Jiang, K. Makinwa, A hybrid multipath CMOS magnetic sensor with 210μTrms resolution and 3MHz bandwidth for contactless current sensing, in 2016 IEEE International Solid-State Circuits Conference (ISSCC) (2016), pp. 204–205, Feb 2016
68.
J.F. Jiang, W.J. Kindt, K.A.A. Makinwa, A continuous-time ripple reduction technique for spinning-current hall sensors. IEEE J. Solid State Circuits 49(7), 1525–1534 (2014)CrossRef
69.
C. Sander, M.C. Vecchi, M. Cornils, O. Paul, From three-contact vertical hall elements to symmetrized vertical hall sensors with low offset. Sens Actuators, A 240, 92–102 (2016)CrossRef
70.
G.M. Sung, C.P. Yu, 2-D differential folded vertical hall device fabricated on a p-type substrate using CMOS technology. IEEE Sensors J. 13(6), 2253–2262 (2013)CrossRef
71.
M. Crescentini, M. Bennati, M. Carminati, M. Tartagni, Noise limits of CMOS current interfaces for biosensors: a review. IEEE Trans. Biomed. Circuits Syst. 8(2), 278–292 (2014)CrossRef
72.
D. Kim, B. Goldstein, W. Tang, F.J. Sigworth, E. Culurciello, Noise analysis and performance comparison of low current measurement systems for biomedical applications. IEEE Trans. Biomed. Circuits Syst. 7(1), 52–62 (2013)CrossRef
73.
K.-M. Lei, H. Heidari, P.-I. Mak, M.-K. Law, F. Maloberti, Exploring the noise limits of fully-differential micro-watt transimpedance amplifiers for Sub-pA/√Hz sensitivity, in 2015 11th Conference on Ph.D. Research in Microelectronics and Electronics (PRIME) (2015a), pp. 290–293, June 2015
74.
L.K. Lee, S. Choi, J.O. Lee, Yoon JB, Cho GH (2012) CMOS capacitive biosensor with enhanced sensitivity for label-free DNA detection, in 2012 IEEE International Solid-State Circuits Conference, pp. 120–122, Feb 2012
75.
A. Manickam, A. Chevalier, M. McDermott, A.D. Ellington, A. Hassibi, A CMOS electrochemical impedance spectroscopy (EIS) biosensor array. IEEE Trans. Biomed. Circuits Syst. 4(6), 379–390 (2010)CrossRef
76.
T.C.D. Huang, S. Sorgenfrei, P. Gong, R. Levicky, K.L. Shepard, A 0.18-μm CMOS array sensor for integrated time-resolved fluorescence detection. IEEE J. Solid State Circuits 44(5), 1644–1654 (2009)CrossRef
77.
H. Norian, R.M. Field, I. Kymissis, K.L. Shepard, An integrated CMOS quantitative-polymerase-chain-reaction lab-on-chip for point-of-care diagnostics. Lab Chip 14(20), 4076–4084 (2014)CrossRef
78.
K.-M. Lei, P.-I. Mak, M.-K. Law, R.P. Martins, CMOS biosensors for in vitro diagnosis – transducing mechanisms and applications. Lab Chip 16, 3664–3681 (2016a)
79.
J. Anders, P. SanGiorgio, G. Boero, A fully integrated IQ-receiver for NMR microscopy. J. Magn. Reson. 209(1), 1–7 (2011)CrossRef
80.
J. Handwerker, M. Eder, M. Tibiletti, V. Rasche, K. Scheffler, J. Becker, M. Ortmanns, J. Anders, An array of fully-integrated quadrature TX/RX NMR field probes for MRI trajectory mapping, in 42nd European Solid-State Circuits Conference (2016b), pp. 217–220, 12–15 Sept 2016
81.
M.J.N. Junk, Electron paramagnetic resonance theory, in Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy, (Springer, Berlin/Heidelberg, 2012), pp. 7–52CrossRef
82.
J. Handwerker, B. Schlecker, U. Wachter, P. Radermacher, M. Ortmanns, J. Anders, A 14GHz battery-operated point-of-care ESR spectrometer based on a 0.13μm CMOS ASIC, in 2016 IEEE International Solid-State Circuits Conference (ISSCC) (2016a), pp. 476–477, 31 Jan–4 Feb 2016
83.
X. Yang, A. Babakhani, A full-duplex single-chip transceiver with self-interference cancellation in 0.13μm SiGe BiCMOS for electron paramagnetic resonance spectroscopy. IEEE J. Solid State Circuits 51(10), 2408–2419 (2016)CrossRef
84.
X. Yang, A. Babakhani, A single-chip electron paramagnetic resonance transceiver in 0.13-μm SiGe BiCMOS. IEEE Trans. Microwave Theory Tech. 63(11), 3727–3735 (2015)CrossRef
Metadaten
Titel
Micro-NMR on CMOS for Biomolecular Sensing
verfasst von
Ka-Meng Lei
Nan Sun
Pui-In Mak
Rui Paulo Martins
Donhee Ham
Copyright-Jahr
2018
Buch
CMOS Circuits for Biological Sensing and Processing

Print ISBN: 978-3-319-67722-4

Electronic ISBN: 978-3-319-67723-1

Copyright-Jahr: 2018

DOI
https://doi.org/10.1007/978-3-319-67723-1_5

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