Skip to main content
Erschienen in:
Buchtitelbild

2017 | OriginalPaper | Buchkapitel

Microenvironment Cytometry

verfasst von : Paul J. Smith, Victoria Griesdoorn, Oscar F. Silvestre, Rachel J. Errington

Erschienen in: Single Cell Analysis

Verlag: Springer Singapore

Aktivieren Sie unsere intelligente Suche um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

It is becoming self-evident that biological systems—from microbes to human tissues—create local microenvironments that can foster survival or impose Darwinian selection that creates unwanted phenotypes. Understanding the dynamic nature of cancer-cell microcommunities in such situations presents a challenge from the conceptual level of cell attractors to the practical level of tracking discrete molecular events and relevant changes by cytometry. There has been a significant increase in the attractiveness of therapeutic strategies that seek to disrupt the ability of neoplastic cells to exploit their microenvironments and present drug-resistant and pro-metastatic phenotypes. Aligned with this is the demand for 3D cellular systems that can mimic aspects of the microenvironment. The chapter discusses methods of cell encapsulation, in particular the application of hollow-fiber technology. Strategies also need to take into account patterns of cellular plasticity and the dynamic heterogeneity in target molecule presentation, especially in co-culture systems. The focus here is on the cytometry of cellular communities within their microenvironments with examples of targeted therapeutic agents. A critical feature of cellular microenvironments, arising from inadequate vascularity, is reduced oxygenation levels. The chapter highlights some of the cellular responses to hypoxia, while research experience suggests that the targeting of hypoxic cells in tumor regions has therapeutic potential.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Jessop R (2012) Coinage of the term environment: a word without authority and carlyle’s displacement of the mechanical metaphor. Lit Compass 9:708–720 Jessop R (2012) Coinage of the term environment: a word without authority and carlyle’s displacement of the mechanical metaphor. Lit Compass 9:708–720
3.
Zurück zum Zitat Ferrari BC, Winsley TJ, Bergquist PL, Van Dorst J (2012) Flow cytometry in environmental microbiology: a rapid approach for the isolation of single cells for advanced molecular biology analysis. Methods Mol Biol 881:3–26. doi:10.1007/978-1-61779-827-6_1 CrossRef Ferrari BC, Winsley TJ, Bergquist PL, Van Dorst J (2012) Flow cytometry in environmental microbiology: a rapid approach for the isolation of single cells for advanced molecular biology analysis. Methods Mol Biol 881:3–26. doi:10.​1007/​978-1-61779-827-6_​1 CrossRef
4.
Zurück zum Zitat Sgier L, Freimann R, Zupanic A, Kroll A (2016) Flow cytometry combined with viSNE for the analysis of microbial biofilms and detection of microplastics. Nat Commun 7:11587. doi:10.1038/ncomms11587 CrossRef Sgier L, Freimann R, Zupanic A, Kroll A (2016) Flow cytometry combined with viSNE for the analysis of microbial biofilms and detection of microplastics. Nat Commun 7:11587. doi:10.​1038/​ncomms11587 CrossRef
9.
Zurück zum Zitat McMillin DW, Negri JM, Mitsiades CS (2013) The role of tumour-stromal interactions in modifying drug response: challenges and opportunities. Nat Rev Drug Discov 12:217–228. doi:10.1038/nrd3870 CrossRef McMillin DW, Negri JM, Mitsiades CS (2013) The role of tumour-stromal interactions in modifying drug response: challenges and opportunities. Nat Rev Drug Discov 12:217–228. doi:10.​1038/​nrd3870 CrossRef
10.
12.
13.
Zurück zum Zitat Pitt JM, Marabelle A, Eggermont A, Soria JC, Kroemer G, Zitvogel L (2016) Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy. Ann Oncol 27:1482–1492. doi:10.1093/annonc/mdw168 CrossRef Pitt JM, Marabelle A, Eggermont A, Soria JC, Kroemer G, Zitvogel L (2016) Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy. Ann Oncol 27:1482–1492. doi:10.​1093/​annonc/​mdw168 CrossRef
17.
Zurück zum Zitat Barker HE, Paget JT, Khan AA, Harrington KJ (2015) The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat Rev Cancer 15:409–425. doi:10.1038/nrc3958 CrossRef Barker HE, Paget JT, Khan AA, Harrington KJ (2015) The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat Rev Cancer 15:409–425. doi:10.​1038/​nrc3958 CrossRef
18.
Zurück zum Zitat Ratajczak MZ, Suszynska M, Kucia M (2016) Does it make sense to target one tumor cell chemotactic factor or its receptor when several chemotactic axes are involved in metastasis of the same cancer? Clin Transl Med 5:28. doi:10.1186/s40169-016-0113-6 CrossRef Ratajczak MZ, Suszynska M, Kucia M (2016) Does it make sense to target one tumor cell chemotactic factor or its receptor when several chemotactic axes are involved in metastasis of the same cancer? Clin Transl Med 5:28. doi:10.​1186/​s40169-016-0113-6 CrossRef
19.
Zurück zum Zitat Smith PJ, Khan IA, and Errington RJ (2009) Cytomics and cellular informatics—coping with asymmetry and heterogeneity in biological systems. Drug Discov Today 14:271–277. doi: 10.1016/j.drudis.2008.11.012, S1359–6446(08)00404-2 [pii] Smith PJ, Khan IA, and Errington RJ (2009) Cytomics and cellular informatics—coping with asymmetry and heterogeneity in biological systems. Drug Discov Today 14:271–277. doi: 10.​1016/​j.​drudis.​2008.​11.​012, S1359–6446(08)00404-2 [pii]
20.
Zurück zum Zitat Smith PJ, Falconer RA, Errington RJ (2013) Micro-community cytometry: sensing changes in cell health and glycoconjugate expression by imaging and flow cytometry. J Microsc 251:113–122. doi:10.1111/jmi.12060 CrossRef Smith PJ, Falconer RA, Errington RJ (2013) Micro-community cytometry: sensing changes in cell health and glycoconjugate expression by imaging and flow cytometry. J Microsc 251:113–122. doi:10.​1111/​jmi.​12060 CrossRef
22.
23.
Zurück zum Zitat Mair F, Hartmann FJ, Mrdjen D, Tosevski V, Krieg C, Becher B (2016) The end of gating? An introduction to automated analysis of high dimensional cytometry data. Eur J Immunol 46:34–43. doi:10.1002/eji.201545774 CrossRef Mair F, Hartmann FJ, Mrdjen D, Tosevski V, Krieg C, Becher B (2016) The end of gating? An introduction to automated analysis of high dimensional cytometry data. Eur J Immunol 46:34–43. doi:10.​1002/​eji.​201545774 CrossRef
26.
Zurück zum Zitat Haldane JB, Waddington CH (1931) Inbreeding and linkage. Genetics 16:357–374 Haldane JB, Waddington CH (1931) Inbreeding and linkage. Genetics 16:357–374
27.
Zurück zum Zitat Waddington CH (1939) Introduction to modern genetics. Macmillan, New York Waddington CH (1939) Introduction to modern genetics. Macmillan, New York
28.
Zurück zum Zitat Esteller M (2009) Epigenetics in biology and medicine. In: Esteller M (ed) C. Press, UK Esteller M (2009) Epigenetics in biology and medicine. In: Esteller M (ed) C. Press, UK
29.
35.
Zurück zum Zitat Li Q, Wennborg A, Aurell E, Dekel E, Zou JZ, Xu Y, Huang S, Ernberg I (2016) Dynamics inside the cancer cell attractor reveal cell heterogeneity, limits of stability, and escape. Proc Natl Acad Sci USA 113:2672–2677. doi:10.1073/pnas.1519210113 CrossRef Li Q, Wennborg A, Aurell E, Dekel E, Zou JZ, Xu Y, Huang S, Ernberg I (2016) Dynamics inside the cancer cell attractor reveal cell heterogeneity, limits of stability, and escape. Proc Natl Acad Sci USA 113:2672–2677. doi:10.​1073/​pnas.​1519210113 CrossRef
37.
Zurück zum Zitat Bennun SV, Hizal DB, Heffner K, Can O, Zhang H, Betenbaugh MJ (2016) Systems glycobiology: integrating glycogenomics, glycoproteomics, glycomics, and other ‘omics data sets to characterize cellular glycosylation processes’. J Mol Biol 428:3337–3352. doi:10.1016/j.jmb.2016.07.005 CrossRef Bennun SV, Hizal DB, Heffner K, Can O, Zhang H, Betenbaugh MJ (2016) Systems glycobiology: integrating glycogenomics, glycoproteomics, glycomics, and other ‘omics data sets to characterize cellular glycosylation processes’. J Mol Biol 428:3337–3352. doi:10.​1016/​j.​jmb.​2016.​07.​005 CrossRef
40.
Zurück zum Zitat Falconer RA, Errington RJ, Shnyder SD, Smith PJ, Patterson LH (2012) Polysialyltransferase: a new target in metastatic cancer. Curr Cancer Drug Targets 12:925–939 Falconer RA, Errington RJ, Shnyder SD, Smith PJ, Patterson LH (2012) Polysialyltransferase: a new target in metastatic cancer. Curr Cancer Drug Targets 12:925–939
41.
Zurück zum Zitat Rutishauser U (1992) NCAM and its polysialic acid moiety: a mechanism for pull/push regulation of cell interactions during development? Dev Suppl 99–104 Rutishauser U (1992) NCAM and its polysialic acid moiety: a mechanism for pull/push regulation of cell interactions during development? Dev Suppl 99–104
42.
Zurück zum Zitat Rutishauser U (2008) Polysialic acid in the plasticity of the developing and adult vertebrate nervous system. Nat Rev Neurosci 9:26–35. doi:10.1038/nrn2285 CrossRef Rutishauser U (2008) Polysialic acid in the plasticity of the developing and adult vertebrate nervous system. Nat Rev Neurosci 9:26–35. doi:10.​1038/​nrn2285 CrossRef
44.
Zurück zum Zitat Al-Saraireh YM, Sutherland M, Springett BR, Freiberger F, Ribeiro Morais G, Loadman PM, Errington RJ, Smith PJ, Fukuda M, Gerardy-Schahn R, Patterson LH, Shnyder SD, Falconer RA (2013) Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration. PLoS ONE 8:e73366. doi:10.1371/journal.pone.0073366 CrossRef Al-Saraireh YM, Sutherland M, Springett BR, Freiberger F, Ribeiro Morais G, Loadman PM, Errington RJ, Smith PJ, Fukuda M, Gerardy-Schahn R, Patterson LH, Shnyder SD, Falconer RA (2013) Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration. PLoS ONE 8:e73366. doi:10.​1371/​journal.​pone.​0073366 CrossRef
45.
Zurück zum Zitat Jokilammi A, Ollikka P, Korja M, Jakobsson E, Loimaranta V, Haataja S, Hirvonen H, Finne J (2004) Construction of antibody mimics from a noncatalytic enzyme-detection of polysialic acid. J Immunol Methods 295:149–160. doi:10.1016/j.jim.2004.10.006, S0022-1759(04)00367-9 [pii] Jokilammi A, Ollikka P, Korja M, Jakobsson E, Loimaranta V, Haataja S, Hirvonen H, Finne J (2004) Construction of antibody mimics from a noncatalytic enzyme-detection of polysialic acid. J Immunol Methods 295:149–160. doi:10.​1016/​j.​jim.​2004.​10.​006, S0022-1759(04)00367-9 [pii]
46.
47.
Zurück zum Zitat Smith PJ, Furon E, Wiltshire M, Chappell S, Patterson LH, Shnyder SD, Falconer RA, Errington RJ (2013) NCAM polysialylation during adherence transitions: live cell monitoring using an antibody-mimetic EGFP-endosialidase and the viability dye DRAQ7. Cytometry A 83:659–671. doi:10.1002/cyto.a.22306 CrossRef Smith PJ, Furon E, Wiltshire M, Chappell S, Patterson LH, Shnyder SD, Falconer RA, Errington RJ (2013) NCAM polysialylation during adherence transitions: live cell monitoring using an antibody-mimetic EGFP-endosialidase and the viability dye DRAQ7. Cytometry A 83:659–671. doi:10.​1002/​cyto.​a.​22306 CrossRef
49.
Zurück zum Zitat Frattini A, Fabbri M, Valli R, De Paoli E, Montalbano G, Gribaldo L, Pasquali F, Maserati E (2015) High variability of genomic instability and gene expression profiling in different HeLa clones. Sci Rep 5:15377. doi:10.1038/srep15377 CrossRef Frattini A, Fabbri M, Valli R, De Paoli E, Montalbano G, Gribaldo L, Pasquali F, Maserati E (2015) High variability of genomic instability and gene expression profiling in different HeLa clones. Sci Rep 5:15377. doi:10.​1038/​srep15377 CrossRef
51.
Zurück zum Zitat Raslova H, Kauffmann A, Sekkai D, Ripoche H, Larbret F, Robert T, Le Roux DT, Kroemer G, Debili N, Dessen P, Lazar V, Vainchenker W (2007) Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach. Blood 109:3225–3234. doi:10.1182/blood-2006-07-037838 CrossRef Raslova H, Kauffmann A, Sekkai D, Ripoche H, Larbret F, Robert T, Le Roux DT, Kroemer G, Debili N, Dessen P, Lazar V, Vainchenker W (2007) Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach. Blood 109:3225–3234. doi:10.​1182/​blood-2006-07-037838 CrossRef
56.
Zurück zum Zitat Rello-Varona S, Vitale I, Kepp O, Senovilla L, Jemaa M, Metivier D, Castedo M, Kroemer G (2009) Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5. Cell Cycle 8:1030–1035. doi:10.4161/cc.8.7.7950 CrossRef Rello-Varona S, Vitale I, Kepp O, Senovilla L, Jemaa M, Metivier D, Castedo M, Kroemer G (2009) Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5. Cell Cycle 8:1030–1035. doi:10.​4161/​cc.​8.​7.​7950 CrossRef
57.
60.
Zurück zum Zitat Smith PJ, Marquez N, Wiltshire M, Chappell S, Njoh K, Campbell L, Khan IA, Silvestre O, Errington RJ (2007) Mitotic bypass via an occult cell cycle phase following DNA topoisomerase II inhibition in p 53 functional human tumor cells. Cell Cycle 6:2071–2081. 4585 [pii] Smith PJ, Marquez N, Wiltshire M, Chappell S, Njoh K, Campbell L, Khan IA, Silvestre O, Errington RJ (2007) Mitotic bypass via an occult cell cycle phase following DNA topoisomerase II inhibition in p 53 functional human tumor cells. Cell Cycle 6:2071–2081. 4585 [pii]
65.
Zurück zum Zitat Gong J, Traganos F, Darzynkiewicz Z (1995) Discrimination of G2 and mitotic cells by flow cytometry based on different expression of cyclins A and B1. Exp Cell Res 220:226–231. doi:10.1006/excr.1995.1310 CrossRef Gong J, Traganos F, Darzynkiewicz Z (1995) Discrimination of G2 and mitotic cells by flow cytometry based on different expression of cyclins A and B1. Exp Cell Res 220:226–231. doi:10.​1006/​excr.​1995.​1310 CrossRef
66.
Zurück zum Zitat Thomas N, Kenrick M, Giesler T, Kiser G, Tinkler H, Stubbs S (2005) Characterization and gene expression profiling of a stable cell line expressing a cell cycle GFP sensor. Cell Cycle 4:191–195 Thomas N, Kenrick M, Giesler T, Kiser G, Tinkler H, Stubbs S (2005) Characterization and gene expression profiling of a stable cell line expressing a cell cycle GFP sensor. Cell Cycle 4:191–195
67.
Zurück zum Zitat Nakazawa N, Mehrotra R, Arakawa O, Yanagida M (2016) ICRF-193, an anticancer topoisomerase II inhibitor, induces arched telophase spindles that snap, leading to a ploidy increase in fission yeast. Genes Cells 21:978–993. doi:10.1111/gtc.12397 CrossRef Nakazawa N, Mehrotra R, Arakawa O, Yanagida M (2016) ICRF-193, an anticancer topoisomerase II inhibitor, induces arched telophase spindles that snap, leading to a ploidy increase in fission yeast. Genes Cells 21:978–993. doi:10.​1111/​gtc.​12397 CrossRef
68.
Zurück zum Zitat Smith PJ, Blunt N, Wiltshire M, Hoy T, Teesdale-Spittle P, Craven MR, Watson JV, Amos WB, Errington RJ, Patterson LH (2000) Characteristics of a novel deep red/infrared fluorescent cell-permeant DNA probe, DRAQ5, in intact human cells analyzed by flow cytometry, confocal and multiphoton microscopy. Cytometry 40:280–291 Smith PJ, Blunt N, Wiltshire M, Hoy T, Teesdale-Spittle P, Craven MR, Watson JV, Amos WB, Errington RJ, Patterson LH (2000) Characteristics of a novel deep red/infrared fluorescent cell-permeant DNA probe, DRAQ5, in intact human cells analyzed by flow cytometry, confocal and multiphoton microscopy. Cytometry 40:280–291
69.
Zurück zum Zitat Choi M, Shi J, Jung SH, Chen X, Cho KH (2012) Attractor landscape analysis reveals feedback loops in the p 53 network that control the cellular response to DNA damage. Sci Signal 5:ra83. doi:10.1126/scisignal.2003363 Choi M, Shi J, Jung SH, Chen X, Cho KH (2012) Attractor landscape analysis reveals feedback loops in the p 53 network that control the cellular response to DNA damage. Sci Signal 5:ra83. doi:10.​1126/​scisignal.​2003363
70.
Zurück zum Zitat Shaltiel IA, Krenning L, Bruinsma W, Medema RH (2015) The same, only different—DNA damage checkpoints and their reversal throughout the cell cycle. J Cell Sci 128:607–620. doi:10.1242/jcs.163766 CrossRef Shaltiel IA, Krenning L, Bruinsma W, Medema RH (2015) The same, only different—DNA damage checkpoints and their reversal throughout the cell cycle. J Cell Sci 128:607–620. doi:10.​1242/​jcs.​163766 CrossRef
72.
73.
Zurück zum Zitat Iwai M, Hara A, Andoh T, Ishida R (1997) ICRF-193, a catalytic inhibitor of DNA topoisomerase II, delays the cell cycle progression from metaphase, but not from anaphase to the G1 phase in mammalian cells. FEBS Lett 406:267–70 Iwai M, Hara A, Andoh T, Ishida R (1997) ICRF-193, a catalytic inhibitor of DNA topoisomerase II, delays the cell cycle progression from metaphase, but not from anaphase to the G1 phase in mammalian cells. FEBS Lett 406:267–70
74.
Zurück zum Zitat Smith PJ, Chin SF, Njoh K, Khan IA, Chappell MJ, Errington RJ (2008) Cell cycle checkpoint-guarded routes to catenation-induced chromosomal instability. SEB Exp Biol Ser 59:219–242 Smith PJ, Chin SF, Njoh K, Khan IA, Chappell MJ, Errington RJ (2008) Cell cycle checkpoint-guarded routes to catenation-induced chromosomal instability. SEB Exp Biol Ser 59:219–242
75.
Zurück zum Zitat Chang LJ, Eastman A (2012) Differential regulation of p21 (waf1) protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications. Cancer Biol Ther 13:1047–1057. doi:10.4161/cbt.21047 CrossRef Chang LJ, Eastman A (2012) Differential regulation of p21 (waf1) protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications. Cancer Biol Ther 13:1047–1057. doi:10.​4161/​cbt.​21047 CrossRef
76.
Zurück zum Zitat Chang LJ, Eastman A (2012) Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors. Cell Cycle 11:1818–1826. doi:10.4161/cc.20208 CrossRef Chang LJ, Eastman A (2012) Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors. Cell Cycle 11:1818–1826. doi:10.​4161/​cc.​20208 CrossRef
79.
Zurück zum Zitat Akagi J, Kordon M, Zhao H, Matuszek A, Dobrucki J, Errington R, Smith PJ, Takeda K, Darzynkiewicz Z, Wlodkowic D (2013) Real-time cell viability assays using a new anthracycline derivative DRAQ7(R). Cytometry A 83:227–234. doi:10.1002/cyto.a.22228 CrossRef Akagi J, Kordon M, Zhao H, Matuszek A, Dobrucki J, Errington R, Smith PJ, Takeda K, Darzynkiewicz Z, Wlodkowic D (2013) Real-time cell viability assays using a new anthracycline derivative DRAQ7(R). Cytometry A 83:227–234. doi:10.​1002/​cyto.​a.​22228 CrossRef
82.
Zurück zum Zitat Liu L, Sun B, Pedersen JN, Aw Yong KM, Getzenberg RH, Stone HA, Austin RH (2011) Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape. Proc Natl Acad Sci USA 108:6853–6856. doi:10.1073/pnas.1102808108 CrossRef Liu L, Sun B, Pedersen JN, Aw Yong KM, Getzenberg RH, Stone HA, Austin RH (2011) Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape. Proc Natl Acad Sci USA 108:6853–6856. doi:10.​1073/​pnas.​1102808108 CrossRef
84.
Zurück zum Zitat Smith PJ, Wiltshire M, Chappell SC, Cosentino L, Burns PA, Pors K, Errington RJ (2013) Kinetic analysis of intracellular Hoechst 33342–DNA interactions by flow cytometry: misinterpretation of side population status? Cytometry A 83:161–169. doi:10.1002/cyto.a.22224 CrossRef Smith PJ, Wiltshire M, Chappell SC, Cosentino L, Burns PA, Pors K, Errington RJ (2013) Kinetic analysis of intracellular Hoechst 33342–DNA interactions by flow cytometry: misinterpretation of side population status? Cytometry A 83:161–169. doi:10.​1002/​cyto.​a.​22224 CrossRef
86.
Zurück zum Zitat Errington RJ, Ameer-Beg SM, Vojnovic B, Patterson LH, Zloh M, Smith PJ (2005) Advanced microscopy solutions for monitoring the kinetics and dynamics of drug-DNA targeting in living cells. Adv Drug Deliv Rev 57:153–167. doi:10.1016/j.addr.2004.05.005 CrossRef Errington RJ, Ameer-Beg SM, Vojnovic B, Patterson LH, Zloh M, Smith PJ (2005) Advanced microscopy solutions for monitoring the kinetics and dynamics of drug-DNA targeting in living cells. Adv Drug Deliv Rev 57:153–167. doi:10.​1016/​j.​addr.​2004.​05.​005 CrossRef
87.
Zurück zum Zitat Evans ND, Errington RJ, Shelley M, Feeney GP, Chapman MJ, Godfrey KR, Smith PJ, Chappell MJ (2004) A mathematical model for the in vitro kinetics of the anti-cancer agent topotecan. Math Biosci 189:185–217. doi:10.1016/j.mbs.2004.01.007, S002555640400063X [pii] Evans ND, Errington RJ, Shelley M, Feeney GP, Chapman MJ, Godfrey KR, Smith PJ, Chappell MJ (2004) A mathematical model for the in vitro kinetics of the anti-cancer agent topotecan. Math Biosci 189:185–217. doi:10.​1016/​j.​mbs.​2004.​01.​007, S002555640400063X [pii]
88.
Zurück zum Zitat Cheung SY, Evans ND, Chappell MJ, Godfrey KR, Smith PJ, Errington RJ (2008) Exploration of the intercellular heterogeneity of topotecan uptake into human breast cancer cells through compartmental modelling. Math Biosci 213:119–134. doi:10.1016/j.mbs.2008.03.008, S0025-5564(08)00059-X [pii] Cheung SY, Evans ND, Chappell MJ, Godfrey KR, Smith PJ, Errington RJ (2008) Exploration of the intercellular heterogeneity of topotecan uptake into human breast cancer cells through compartmental modelling. Math Biosci 213:119–134. doi:10.​1016/​j.​mbs.​2008.​03.​008, S0025-5564(08)00059-X [pii]
90.
Zurück zum Zitat Thanos CG, Bintz B, Emerich DF (2010) Microencapsulated choroid plexus epithelial cell transplants for repair of the brain. Adv Exp Med Biol 670:80–91 Thanos CG, Bintz B, Emerich DF (2010) Microencapsulated choroid plexus epithelial cell transplants for repair of the brain. Adv Exp Med Biol 670:80–91
91.
Zurück zum Zitat Uludag H, De Vos P, Tresco PA (2000) Technology of mammalian cell encapsulation. Adv Drug Deliv Rev 42:29–64 Uludag H, De Vos P, Tresco PA (2000) Technology of mammalian cell encapsulation. Adv Drug Deliv Rev 42:29–64
92.
Zurück zum Zitat Workman VL, Dunnett SB, Kille P, Palmer DD (2007) Microfluidic chip-based synthesis of alginate microspheres for encapsulation of immortalized human cells. Biomicrofluidics 1(1):014105. doi:10.1063/1.2431860 Workman VL, Dunnett SB, Kille P, Palmer DD (2007) Microfluidic chip-based synthesis of alginate microspheres for encapsulation of immortalized human cells. Biomicrofluidics 1(1):014105. doi:10.​1063/​1.​2431860
93.
Zurück zum Zitat Lanza RP, Butler DH, Borland KM, Staruk JE, Faustman DL, Solomon BA, Muller TE, Rupp RG, Maki T, Monaco AP, Chick WL (1991) Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression. Proc Nat Acad Sci USA 88:11100–11104 Lanza RP, Butler DH, Borland KM, Staruk JE, Faustman DL, Solomon BA, Muller TE, Rupp RG, Maki T, Monaco AP, Chick WL (1991) Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression. Proc Nat Acad Sci USA 88:11100–11104
94.
Zurück zum Zitat Hollingshead MG, Alley MC, Camalier RF, Abbott BJ, Mayo JG, Malspeis L, Grever MR (1995) In vivo cultivation of tumor cells in hollow fibers. Life Sci 57:131–141 Hollingshead MG, Alley MC, Camalier RF, Abbott BJ, Mayo JG, Malspeis L, Grever MR (1995) In vivo cultivation of tumor cells in hollow fibers. Life Sci 57:131–141
95.
Zurück zum Zitat Casciari JJ, Hollingshead MG, Alley MC, Mayo JG, Malspeis L, Miyauchi S, Grever MR, Weinstein JN (1994) Growth and chemotherapeutic response of cells in a hollow-fiber in-vitro solid tumor-model. J Nat Cancer Inst 86:1846–1852 Casciari JJ, Hollingshead MG, Alley MC, Mayo JG, Malspeis L, Miyauchi S, Grever MR, Weinstein JN (1994) Growth and chemotherapeutic response of cells in a hollow-fiber in-vitro solid tumor-model. J Nat Cancer Inst 86:1846–1852
96.
Zurück zum Zitat Roberts I, Baila S, Rice RB, Janssens ME, Nguyen K, Moens N, Ruban L, Hernandez D, Coffey P, Mason C (2012) Scale-up of human embryonic stem cell culture using a hollow fibre bioreactor. Biotechnol Lett 34:2307–2315. doi:10.1007/s10529-012-1033-1 CrossRef Roberts I, Baila S, Rice RB, Janssens ME, Nguyen K, Moens N, Ruban L, Hernandez D, Coffey P, Mason C (2012) Scale-up of human embryonic stem cell culture using a hollow fibre bioreactor. Biotechnol Lett 34:2307–2315. doi:10.​1007/​s10529-012-1033-1 CrossRef
98.
Zurück zum Zitat Bettahalli NM, Groen N, Steg H, Unadkat H, de Boer J, van Blitterswijk CA, Wessling M, Stamatialis D (2014) Development of multilayer constructs for tissue engineering. J Tissue Eng Regen Med 8:106–119. doi:10.1002/term.1504 CrossRef Bettahalli NM, Groen N, Steg H, Unadkat H, de Boer J, van Blitterswijk CA, Wessling M, Stamatialis D (2014) Development of multilayer constructs for tissue engineering. J Tissue Eng Regen Med 8:106–119. doi:10.​1002/​term.​1504 CrossRef
100.
Zurück zum Zitat Lamers CHJ, Gratama JW, Luider-Vrieling B, Bolhuis RLH, and Bast E (1999) Large-scale production of natural cytokines during activation and expansion of human T lymphocytes in hollow fiber bioreactor cultures. J Immunother 22:299–307 Lamers CHJ, Gratama JW, Luider-Vrieling B, Bolhuis RLH, and Bast E (1999) Large-scale production of natural cytokines during activation and expansion of human T lymphocytes in hollow fiber bioreactor cultures. J Immunother 22:299–307
102.
Zurück zum Zitat Kalbfuss B, Genzel Y, Wolff M, Zimmermann A, Morenweiser R, Reichl U (2007) Harvesting and concentration of human influenza A virus produced in serum-free mammalian cell culture for the production of vaccines. Biotechnol Bioeng 97:73–85. doi:10.1002/bit.21139 CrossRef Kalbfuss B, Genzel Y, Wolff M, Zimmermann A, Morenweiser R, Reichl U (2007) Harvesting and concentration of human influenza A virus produced in serum-free mammalian cell culture for the production of vaccines. Biotechnol Bioeng 97:73–85. doi:10.​1002/​bit.​21139 CrossRef
103.
Zurück zum Zitat Schmelzer E, Triolo F, Turner ME, Thompson RL, Zeilinger K, Reid LM, Gridelli B, Gerlach JC (2010) Three-dimensional perfusion bioreactor culture supports differentiation of human fetal liver cells. Tissue Eng Part A 16:2007–2016. doi:10.1089/ten.tea.2009.0569 CrossRef Schmelzer E, Triolo F, Turner ME, Thompson RL, Zeilinger K, Reid LM, Gridelli B, Gerlach JC (2010) Three-dimensional perfusion bioreactor culture supports differentiation of human fetal liver cells. Tissue Eng Part A 16:2007–2016. doi:10.​1089/​ten.​tea.​2009.​0569 CrossRef
104.
Zurück zum Zitat Lu HF, Lim WS, Zhang PC, Chia SM, Yu H, Mao HQ, Leong KW (2005) Galactosylated poly(vinylidene difluoride) hollow fiber bioreactor for hepatocyte culture. Tissue Eng 11:1667–1677 Lu HF, Lim WS, Zhang PC, Chia SM, Yu H, Mao HQ, Leong KW (2005) Galactosylated poly(vinylidene difluoride) hollow fiber bioreactor for hepatocyte culture. Tissue Eng 11:1667–1677
106.
Zurück zum Zitat Chen G, Palmer AF (2009) Hemoglobin-based oxygen carrier and convection enhanced oxygen transport in a hollow fiber bioreactor. Biotechnol Bioeng 102:1603–1612. doi:10.1002/bit.22200 CrossRef Chen G, Palmer AF (2009) Hemoglobin-based oxygen carrier and convection enhanced oxygen transport in a hollow fiber bioreactor. Biotechnol Bioeng 102:1603–1612. doi:10.​1002/​bit.​22200 CrossRef
107.
Zurück zum Zitat Westmuckett AD, Lupu C, Roquefeuil S, Krausz T, Kakkar VV, and Lupu F (2000) Fluid flow induces upregulation of synthesis and release of tissue factor pathway inhibitor in vitro. Arterioscler Thromb Vasc Biol 20:2474–2482 Westmuckett AD, Lupu C, Roquefeuil S, Krausz T, Kakkar VV, and Lupu F (2000) Fluid flow induces upregulation of synthesis and release of tissue factor pathway inhibitor in vitro. Arterioscler Thromb Vasc Biol 20:2474–2482
108.
Zurück zum Zitat Godara P, McFarland CD, Nordon RE (2008) Design of bioreactors for mesenchymal stem cell tissue engineering. J Chem Technol Biotechnol 83:408–420 Godara P, McFarland CD, Nordon RE (2008) Design of bioreactors for mesenchymal stem cell tissue engineering. J Chem Technol Biotechnol 83:408–420
109.
Zurück zum Zitat Cucullo L, Couraud PO, Weksler B, Romero IA, Hossain M, Rapp E, Janigro D (2008) Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies. J Cereb Blood Flow Metab 28:312–328. doi:10.1038/sj.jcbfm.9600525 CrossRef Cucullo L, Couraud PO, Weksler B, Romero IA, Hossain M, Rapp E, Janigro D (2008) Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies. J Cereb Blood Flow Metab 28:312–328. doi:10.​1038/​sj.​jcbfm.​9600525 CrossRef
110.
111.
112.
Zurück zum Zitat Li M, Tilles AW, Milwid JM, Hammad M, Lee J, Yarmush ML, Parekkadan B (2012) Phenotypic and functional characterization of human bone marrow stromal cells in hollow-fibre bioreactors. J Tissue Eng Regen Med 6:369–377. doi:10.1002/term.439 CrossRef Li M, Tilles AW, Milwid JM, Hammad M, Lee J, Yarmush ML, Parekkadan B (2012) Phenotypic and functional characterization of human bone marrow stromal cells in hollow-fibre bioreactors. J Tissue Eng Regen Med 6:369–377. doi:10.​1002/​term.​439 CrossRef
113.
Zurück zum Zitat Lubberstedt M, Muller-Vieira U, Biemel KM, Darnell M, Hoffmann SA, Knospel F, Wonne EC, Knobeloch D, Nussler AK, Gerlach JC, Andersson TB, Zeilinger K (2015) Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies. J Tissue Eng Regen Med 9:1017–1026. doi:10.1002/term.1652 CrossRef Lubberstedt M, Muller-Vieira U, Biemel KM, Darnell M, Hoffmann SA, Knospel F, Wonne EC, Knobeloch D, Nussler AK, Gerlach JC, Andersson TB, Zeilinger K (2015) Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies. J Tissue Eng Regen Med 9:1017–1026. doi:10.​1002/​term.​1652 CrossRef
114.
Zurück zum Zitat Billecke N, Raschzok N, Rohn S, Morgul MH, Schwartlander R, Mogl M, Wollersheim S, Schmitt KR, Sauer IM (2012) An operational concept for long-term cinemicrography of cells in mono- and co-culture under highly controlled conditions—the SlideObserver. J Biotechnol 159:83–89. doi:10.1016/j.jbiotec.2012.01.033 CrossRef Billecke N, Raschzok N, Rohn S, Morgul MH, Schwartlander R, Mogl M, Wollersheim S, Schmitt KR, Sauer IM (2012) An operational concept for long-term cinemicrography of cells in mono- and co-culture under highly controlled conditions—the SlideObserver. J Biotechnol 159:83–89. doi:10.​1016/​j.​jbiotec.​2012.​01.​033 CrossRef
115.
Zurück zum Zitat Decker S, Hollingshead M, Bonomi CA, Carter JP, Sausville EA (2004) The hollow fibre model in cancer drug screening: the NCI experience. Eur J Cancer 40:821–826 Decker S, Hollingshead M, Bonomi CA, Carter JP, Sausville EA (2004) The hollow fibre model in cancer drug screening: the NCI experience. Eur J Cancer 40:821–826
116.
Zurück zum Zitat Suggitt M, Bibby MC (2005) 50 years of preclinical anticancer drug screening: Empirical to target-driven approaches. Clin Cancer Res 11:971–981 Suggitt M, Bibby MC (2005) 50 years of preclinical anticancer drug screening: Empirical to target-driven approaches. Clin Cancer Res 11:971–981
117.
Zurück zum Zitat Johnson JI, Decker S, Zaharevitz D, Rubinstein LV, Venditti J, Schepartz S, Kalyandrug S, Christian M, Arbuck S, Hollingshead M, Sausville EA (2001) Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br J Cancer 84:1424–1431 Johnson JI, Decker S, Zaharevitz D, Rubinstein LV, Venditti J, Schepartz S, Kalyandrug S, Christian M, Arbuck S, Hollingshead M, Sausville EA (2001) Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br J Cancer 84:1424–1431
118.
Zurück zum Zitat Sharma SV, Haber DA, Settleman J (2010) Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents. Nat Rev Cancer 10:241–253. doi:10.1038/nrc2820 CrossRef Sharma SV, Haber DA, Settleman J (2010) Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents. Nat Rev Cancer 10:241–253. doi:10.​1038/​nrc2820 CrossRef
119.
Zurück zum Zitat Zhang GJ, Chen TB, Bednar B, Connolly BM, Hargreaves R, Sur C, Williams DL (2007) Optical Imaging of tumor cells in hollow fibers: evaluation of the antitumor activities of anticancer drugs and target validation. Neoplasia 9:652–661. doi:10.1593/neo.07421 CrossRef Zhang GJ, Chen TB, Bednar B, Connolly BM, Hargreaves R, Sur C, Williams DL (2007) Optical Imaging of tumor cells in hollow fibers: evaluation of the antitumor activities of anticancer drugs and target validation. Neoplasia 9:652–661. doi:10.​1593/​neo.​07421 CrossRef
120.
Zurück zum Zitat Zhang GJ, Safran M, Wei WY, Sorensen E, Lassota P, Zhelev N, Neuberg DS, Shapiro G, Kaelin WG (2004) Bioluminescent imaging of Cdk2 inhibition in vivo. Nat Med 10:643–648 Zhang GJ, Safran M, Wei WY, Sorensen E, Lassota P, Zhelev N, Neuberg DS, Shapiro G, Kaelin WG (2004) Bioluminescent imaging of Cdk2 inhibition in vivo. Nat Med 10:643–648
121.
Zurück zum Zitat Pearce CJ, Lantvit DD, Shen Q, Jarjoura D, Zhang X, Oberlies NH, Kroll DJ, Wani MC, Orjala J, Soejarto DD, Farnsworth NR, de Blanco EJ, Fuchs JR, Kinghorn AD, Swanson SM (2012) Use of the hollow fiber assay for the discovery of novel anticancer agents from fungi. Methods Mol Biol 944:267–277. doi:10.1007/978-1-62703-122-6_20 CrossRef Pearce CJ, Lantvit DD, Shen Q, Jarjoura D, Zhang X, Oberlies NH, Kroll DJ, Wani MC, Orjala J, Soejarto DD, Farnsworth NR, de Blanco EJ, Fuchs JR, Kinghorn AD, Swanson SM (2012) Use of the hollow fiber assay for the discovery of novel anticancer agents from fungi. Methods Mol Biol 944:267–277. doi:10.​1007/​978-1-62703-122-6_​20 CrossRef
122.
Zurück zum Zitat Mi Q, Pezzuto JM, Farnsworth NR, Wani MC, Kinghorn AD, Swanson SM (2009) Use of the in vivo hollow fiber assay in natural products anticancer drug discovery. J Nat Prod 72:573–580. doi:10.1021/np800767a CrossRef Mi Q, Pezzuto JM, Farnsworth NR, Wani MC, Kinghorn AD, Swanson SM (2009) Use of the in vivo hollow fiber assay in natural products anticancer drug discovery. J Nat Prod 72:573–580. doi:10.​1021/​np800767a CrossRef
123.
Zurück zum Zitat Shnyder SD (2009) Use of the hollow fibre assay for studies of tumor neovasculature. Methods Mol Biol 467:331–42 Shnyder SD (2009) Use of the hollow fibre assay for studies of tumor neovasculature. Methods Mol Biol 467:331–42
124.
Zurück zum Zitat Shnyder SD, Hasan J, Cooper PA, Pilarinou E, Jubb E, Jayson GC, Bibby MC (2005) Development of a modified hollow fibre assay for studying agents targeting the tumour neovasculature. Anticancer Res 25:1889–1894 Shnyder SD, Hasan J, Cooper PA, Pilarinou E, Jubb E, Jayson GC, Bibby MC (2005) Development of a modified hollow fibre assay for studying agents targeting the tumour neovasculature. Anticancer Res 25:1889–1894
125.
Zurück zum Zitat Temmink OH, Prins HJ, van Gelderop E, Peters GJ (2007) The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells. Br J Cancer 96:61–66 Temmink OH, Prins HJ, van Gelderop E, Peters GJ (2007) The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells. Br J Cancer 96:61–66
127.
Zurück zum Zitat Thomas N (2003) Lighting the circle of life: fluorescent sensors for covert surveillance of the cell cycle. Cell cycle 2:545–549 (Georgetown, Tex) Thomas N (2003) Lighting the circle of life: fluorescent sensors for covert surveillance of the cell cycle. Cell cycle 2:545–549 (Georgetown, Tex)
128.
129.
Zurück zum Zitat Hassan SB, de la Torre M, Nygren P, Karlsson MO, Larsson R, Jonsson E (2001) A hollow fiber model for in vitro studies of cytotoxic compounds: activity of the cyanoguanidine CHS 828. AntiCancer Drugs 12:33–42 Hassan SB, de la Torre M, Nygren P, Karlsson MO, Larsson R, Jonsson E (2001) A hollow fiber model for in vitro studies of cytotoxic compounds: activity of the cyanoguanidine CHS 828. AntiCancer Drugs 12:33–42
130.
Zurück zum Zitat Sadar MD, Akopian VA, Beraldi E (2002) Characterization of a new in vivo hollow fiber model for the study of progression of prostate cancer to androgen independence. Mol Cancer Ther 1:629–637 Sadar MD, Akopian VA, Beraldi E (2002) Characterization of a new in vivo hollow fiber model for the study of progression of prostate cancer to androgen independence. Mol Cancer Ther 1:629–637
131.
Zurück zum Zitat Liu D, Queva C, Ready S, Webster K, Zabludoff S (2004) Testing cell cycle regulation effect of a compound using a hollow fibre cell implant. Patent number: WO2004106924 Liu D, Queva C, Ready S, Webster K, Zabludoff S (2004) Testing cell cycle regulation effect of a compound using a hollow fibre cell implant. Patent number: WO2004106924
132.
Zurück zum Zitat Suggitt M, Swaine DJ, Pettit GR, Bibby MC (2004) Characterization of the hollow fiber assay for the determination of microtubule disruption in vivo. Clin Cancer Res 10:6677–6685 Suggitt M, Swaine DJ, Pettit GR, Bibby MC (2004) Characterization of the hollow fiber assay for the determination of microtubule disruption in vivo. Clin Cancer Res 10:6677–6685
133.
Zurück zum Zitat Bishai WR, Karakousis PC (2006) Hollow fiber technique for in vivo study of cell populations. Patent Number US2006182685 Bishai WR, Karakousis PC (2006) Hollow fiber technique for in vivo study of cell populations. Patent Number US2006182685
134.
Zurück zum Zitat Bridges EM, Bibby MC, Burchill SA (2006) The hollow fiber assay for drug responsiveness in the Ewing’s sarcoma family of tumors. J Pediatr 149:103–111 Bridges EM, Bibby MC, Burchill SA (2006) The hollow fiber assay for drug responsiveness in the Ewing’s sarcoma family of tumors. J Pediatr 149:103–111
137.
Zurück zum Zitat Hollingshead MG, Bonomi CA, Borgel SD, Carter JP, Shoemaker R, Melillo G, Sausville EA (2004) A potential role for imaging technology in anticancer efficacy evaluations. Eur J Cancer 40:890–898 Hollingshead MG, Bonomi CA, Borgel SD, Carter JP, Shoemaker R, Melillo G, Sausville EA (2004) A potential role for imaging technology in anticancer efficacy evaluations. Eur J Cancer 40:890–898
138.
Zurück zum Zitat Zhang GJ, Chen TB, Hargreaves R, Sur C, Williams DL (2008) Bioluminescence imaging of hollow fibers in living animals: its application in monitoring molecular pathways. Nat Protoc 3:891–899. doi:10.1038/nprot.2008.52 CrossRef Zhang GJ, Chen TB, Hargreaves R, Sur C, Williams DL (2008) Bioluminescence imaging of hollow fibers in living animals: its application in monitoring molecular pathways. Nat Protoc 3:891–899. doi:10.​1038/​nprot.​2008.​52 CrossRef
139.
Zurück zum Zitat Zhang GJ, Kaelin WG (2005) Bioluminescent imaging of ubiquitin ligase activity: measuring cdk2 activity in vivo through changes in p 27 turnover. In: Ubiquitin and Protein Degradation, Pt B. 2005, Elsevier Academic Press Inc, San Diego, p 530-+ Zhang GJ, Kaelin WG (2005) Bioluminescent imaging of ubiquitin ligase activity: measuring cdk2 activity in vivo through changes in p 27 turnover. In: Ubiquitin and Protein Degradation, Pt B. 2005, Elsevier Academic Press Inc, San Diego, p 530-+
142.
143.
Zurück zum Zitat Chouaib S, Noman MZ, Kosmatopoulos K, Curran MA (2016) Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer. Oncogene. doi:10.1038/onc.2016.225 Chouaib S, Noman MZ, Kosmatopoulos K, Curran MA (2016) Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer. Oncogene. doi:10.​1038/​onc.​2016.​225
145.
Zurück zum Zitat Ming L, Byrne NM, Camac SN, Mitchell CA, Ward C, Waugh DJ, McKeown SR, Worthington J (2013) Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours: informed scheduling of the bioreductive drug AQ4N improves treatment response. Int J Cancer 132:1323–1332. doi:10.1002/ijc.27796 CrossRef Ming L, Byrne NM, Camac SN, Mitchell CA, Ward C, Waugh DJ, McKeown SR, Worthington J (2013) Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours: informed scheduling of the bioreductive drug AQ4N improves treatment response. Int J Cancer 132:1323–1332. doi:10.​1002/​ijc.​27796 CrossRef
146.
Zurück zum Zitat Dubois LJ, Niemans R, van Kuijk SJ, Panth KM, Parvathaneni NK, Peeters SG, Zegers CM, Rekers NH, van Gisbergen MW, Biemans R, Lieuwes NG, Spiegelberg L, Yaromina A, Winum JY, Vooijs M, Lambin P (2015) New ways to image and target tumour hypoxia and its molecular responses. Radiother Oncol 116:352–357. doi:10.1016/j.radonc.2015.08.022 CrossRef Dubois LJ, Niemans R, van Kuijk SJ, Panth KM, Parvathaneni NK, Peeters SG, Zegers CM, Rekers NH, van Gisbergen MW, Biemans R, Lieuwes NG, Spiegelberg L, Yaromina A, Winum JY, Vooijs M, Lambin P (2015) New ways to image and target tumour hypoxia and its molecular responses. Radiother Oncol 116:352–357. doi:10.​1016/​j.​radonc.​2015.​08.​022 CrossRef
147.
Zurück zum Zitat Ljungkvist AS, Bussink J, Kaanders JH, van der Kogel AJ (2007) Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers. Radiat Res 167:127–45 Ljungkvist AS, Bussink J, Kaanders JH, van der Kogel AJ (2007) Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers. Radiat Res 167:127–45
148.
Zurück zum Zitat Tafreshi NK, Lloyd MC, Proemsey JB, Bui MM, Kim J, Gillies RJ, Morse DL (2016) Evaluation of CAIX and CAXII expression in breast cancer at varied O2 levels: CAIX is the superior surrogate imaging biomarker of tumor hypoxia. Mol Imaging Biol 18:219–231. doi:10.1007/s11307-015-0885-x CrossRef Tafreshi NK, Lloyd MC, Proemsey JB, Bui MM, Kim J, Gillies RJ, Morse DL (2016) Evaluation of CAIX and CAXII expression in breast cancer at varied O2 levels: CAIX is the superior surrogate imaging biomarker of tumor hypoxia. Mol Imaging Biol 18:219–231. doi:10.​1007/​s11307-015-0885-x CrossRef
149.
Zurück zum Zitat Fleming IN, Manavaki R, Blower PJ, West C, Williams KJ, Harris AL, Domarkas J, Lord S, Baldry C, Gilbert FJ (2015) Imaging tumour hypoxia with positron emission tomography. Br J Cancer 112:238–250. doi:10.1038/bjc.2014.610 CrossRef Fleming IN, Manavaki R, Blower PJ, West C, Williams KJ, Harris AL, Domarkas J, Lord S, Baldry C, Gilbert FJ (2015) Imaging tumour hypoxia with positron emission tomography. Br J Cancer 112:238–250. doi:10.​1038/​bjc.​2014.​610 CrossRef
150.
Zurück zum Zitat Tran LB, Bol A, Labar D, Jordan B, Magat J, Mignion L, Gregoire V, Gallez B (2012) Hypoxia imaging with the nitroimidazole 18F-FAZA PET tracer: a comparison with OxyLite, EPR oximetry and 19F-MRI relaxometry. Radiother Oncol 105:29–35. doi:10.1016/j.radonc.2012.04.011 CrossRef Tran LB, Bol A, Labar D, Jordan B, Magat J, Mignion L, Gregoire V, Gallez B (2012) Hypoxia imaging with the nitroimidazole 18F-FAZA PET tracer: a comparison with OxyLite, EPR oximetry and 19F-MRI relaxometry. Radiother Oncol 105:29–35. doi:10.​1016/​j.​radonc.​2012.​04.​011 CrossRef
151.
Zurück zum Zitat Andersen AP, Moreira JMA, Pedersen SF (2014) Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment. Philos Trans Royal Soc B Biol Sci 369:20130098. doi:10.1098/rstb.2013.0098 CrossRef Andersen AP, Moreira JMA, Pedersen SF (2014) Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment. Philos Trans Royal Soc B Biol Sci 369:20130098. doi:10.​1098/​rstb.​2013.​0098 CrossRef
153.
Zurück zum Zitat Davies LC, Rosas M, Smith PJ, Fraser DJ, Jones SA, Taylor PR (2011) A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. Eur J Immunol 41:2155–2164. doi:10.1002/eji.201141817 CrossRef Davies LC, Rosas M, Smith PJ, Fraser DJ, Jones SA, Taylor PR (2011) A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. Eur J Immunol 41:2155–2164. doi:10.​1002/​eji.​201141817 CrossRef
154.
Zurück zum Zitat Zhang G, Liu H, Huang J, Chen S, Pan X, Huang H, Wang L (2016) TREM-1low is a novel characteristic for tumor-associated macrophages in lung cancer. Oncotarget 7:40508–40517. doi:10.18632/oncotarget.9639 Zhang G, Liu H, Huang J, Chen S, Pan X, Huang H, Wang L (2016) TREM-1low is a novel characteristic for tumor-associated macrophages in lung cancer. Oncotarget 7:40508–40517. doi:10.​18632/​oncotarget.​9639
155.
156.
Zurück zum Zitat Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, Cyrus N, Brokowski CE, Eisenbarth SC, Phillips GM, Cline GW, Phillips AJ, Medzhitov R (2014) Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature 513:559–563. doi:10.1038/nature13490 CrossRef Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, Cyrus N, Brokowski CE, Eisenbarth SC, Phillips GM, Cline GW, Phillips AJ, Medzhitov R (2014) Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature 513:559–563. doi:10.​1038/​nature13490 CrossRef
157.
Zurück zum Zitat Kao SH, Wu KJ, Lee WH (2016) Hypoxia, epithelial-mesenchymal transition, and TET-mediated epigenetic changes. J Clin Med 5. doi:10.3390/jcm5020024 Kao SH, Wu KJ, Lee WH (2016) Hypoxia, epithelial-mesenchymal transition, and TET-mediated epigenetic changes. J Clin Med 5. doi:10.​3390/​jcm5020024
158.
Zurück zum Zitat Kusuma S, Zhao S, Gerecht S (2012) The extracellular matrix is a novel attribute of endothelial progenitors and of hypoxic mature endothelial cells. Faseb J 26:4925–4936. doi:10.1096/fj.12-209296 CrossRef Kusuma S, Zhao S, Gerecht S (2012) The extracellular matrix is a novel attribute of endothelial progenitors and of hypoxic mature endothelial cells. Faseb J 26:4925–4936. doi:10.​1096/​fj.​12-209296 CrossRef
159.
Zurück zum Zitat Ioannou M, Papamichali R, Kouvaras E, Mylonis I, Vageli D, Kerenidou T, Barbanis S, Daponte A, Simos G, Gourgoulianis K, Koukoulis GK (2009) Hypoxia inducible factor-1 alpha and vascular endothelial growth factor in biopsies of small cell lung carcinoma. Lung 187:321–329. doi:10.1007/s00408-009-9169-z CrossRef Ioannou M, Papamichali R, Kouvaras E, Mylonis I, Vageli D, Kerenidou T, Barbanis S, Daponte A, Simos G, Gourgoulianis K, Koukoulis GK (2009) Hypoxia inducible factor-1 alpha and vascular endothelial growth factor in biopsies of small cell lung carcinoma. Lung 187:321–329. doi:10.​1007/​s00408-009-9169-z CrossRef
161.
162.
Zurück zum Zitat Thomlinson RH, Gray LH (1955) The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 9:539–49 Thomlinson RH, Gray LH (1955) The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 9:539–49
163.
Zurück zum Zitat Margolin AA (2013) Oncogenic driver mutations: Neither tissue-specific nor independent. Sci Transl Med 5:214ec200 Margolin AA (2013) Oncogenic driver mutations: Neither tissue-specific nor independent. Sci Transl Med 5:214ec200
164.
Zurück zum Zitat Liang D, Miller GH, Tranmer GK (2015) Hypoxia activated prodrugs: factors influencing design and development. Curr Med Chem 22:4313–25 Liang D, Miller GH, Tranmer GK (2015) Hypoxia activated prodrugs: factors influencing design and development. Curr Med Chem 22:4313–25
167.
Zurück zum Zitat Guise CP, Mowday AM, Ashoorzadeh A, Yuan R, Lin WH, Wu DH, Smaill JB, Patterson AV, Ding K (2014) Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia. Chin J Cancer 33:80–86. doi:10.5732/cjc.012.10285 CrossRef Guise CP, Mowday AM, Ashoorzadeh A, Yuan R, Lin WH, Wu DH, Smaill JB, Patterson AV, Ding K (2014) Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia. Chin J Cancer 33:80–86. doi:10.​5732/​cjc.​012.​10285 CrossRef
168.
169.
Zurück zum Zitat Foehrenbacher A, Secomb TW, Wilson WR, Hicks KO (2013) Design of optimized hypoxia-activated prodrugs using pharmacokinetic/pharmacodynamic modeling. Front Oncol 3:314. doi:10.3389/fonc.2013.00314 Foehrenbacher A, Secomb TW, Wilson WR, Hicks KO (2013) Design of optimized hypoxia-activated prodrugs using pharmacokinetic/pharmacodynamic modeling. Front Oncol 3:314. doi:10.​3389/​fonc.​2013.​00314
170.
Zurück zum Zitat Meng F, Evans JW, Bhupathi D, Banica M, Lan L, Lorente G, Duan JX, Cai X, Mowday AM, Guise CP, Maroz A, Anderson RF, Patterson AV, Stachelek GC, Glazer PM, Matteucci MD, Hart CP (2012) Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302. Mol Cancer Ther 11:740–751. doi:10.1158/1535-7163.mct-11-0634 CrossRef Meng F, Evans JW, Bhupathi D, Banica M, Lan L, Lorente G, Duan JX, Cai X, Mowday AM, Guise CP, Maroz A, Anderson RF, Patterson AV, Stachelek GC, Glazer PM, Matteucci MD, Hart CP (2012) Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302. Mol Cancer Ther 11:740–751. doi:10.​1158/​1535-7163.​mct-11-0634 CrossRef
171.
Zurück zum Zitat Albertella MR, Loadman PM, Jones PH, Phillips RM, Rampling R, Burnet N, Alcock C, Anthoney A, Vjaters E, Dunk CR, Harris PA, Wong A, Lalani AS, Twelves CJ (2008) Hypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: results of a phase I study. Clin Cancer Res 14:1096–1104. doi:10.1158/1078-0432.ccr-07-4020 CrossRef Albertella MR, Loadman PM, Jones PH, Phillips RM, Rampling R, Burnet N, Alcock C, Anthoney A, Vjaters E, Dunk CR, Harris PA, Wong A, Lalani AS, Twelves CJ (2008) Hypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: results of a phase I study. Clin Cancer Res 14:1096–1104. doi:10.​1158/​1078-0432.​ccr-07-4020 CrossRef
172.
Zurück zum Zitat Nesbitt H, Byrne NM, Williams N, Ming L, Worthington J, Errington RJ, Patterson LH, Smith P, McKeown SR, McKenna DJ (2016) Targeting hypoxic prostate tumours using the novel hypoxia-activated prodrug OCT1002 inhibits expression of genes associated with malignant progression. Clin Cancer Res. doi:10.1158/1078-0432.ccr-16-1361 Nesbitt H, Byrne NM, Williams N, Ming L, Worthington J, Errington RJ, Patterson LH, Smith P, McKeown SR, McKenna DJ (2016) Targeting hypoxic prostate tumours using the novel hypoxia-activated prodrug OCT1002 inhibits expression of genes associated with malignant progression. Clin Cancer Res. doi:10.​1158/​1078-0432.​ccr-16-1361
Metadaten
Titel
Microenvironment Cytometry
verfasst von
Paul J. Smith
Victoria Griesdoorn
Oscar F. Silvestre
Rachel J. Errington
Copyright-Jahr
2017
Verlag
Springer Singapore
DOI
https://doi.org/10.1007/978-981-10-4499-1_1

Neuer Inhalt