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Erschienen in:
2018 | OriginalPaper | Buchkapitel
Milligels Synthesis and Characterization: Mebeverine Hydrochloride Uptake and Release
verfasst von : N. Baït, B. Grassl, A. Benaboura
Erschienen in: Proceedings of the Third International Symposium on Materials and Sustainable Development
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Abstract
This study describes the millifluidic-based synthesis of conventional Polyacrylamide (PAM), Polyacrylamide-Sodium Montmorillonite (PAM-NaMMT) and Polyacrylamide-Organo-modified Montmorillonite (PAM-OMMT) composite milligels. These hydrogel particles with millimeter size are intended to be used for the design of Drug Delivery Systems (DDS) combining hydrogels and Clay performances. The composite hydrogels structure, the interactions between the PAM chains and the Clay and the networks thermal behavior were evidenced by Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) respectively. PAM, PAM-NaMMT and PAM-OMMT milligels potential loading and release of Mebeverine Hydrochloride, taken as a model molecule, was investigated by UV Spectroscopy. This potential was examined as a function of the release medium, the networks chemical composition, the Montmorillonite (MMT) nature and its content.