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Erschienen in:
2017 | OriginalPaper | Buchkapitel
Modeling PI3K/PDK1/Akt and MAPK Signaling Pathways Using Continuous Petri Nets
verfasst von : Giulia Russo, Marzio Pennisi, Roberta Boscarino, Francesco Pappalardo
Erschienen in: Intelligent Computing Theories and Application
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Abstract
Malignant melanoma is an invasive skin cancer commonly resistant to conventional therapeutic approaches. Genetic and molecular alterations as mutations of BRAF gene, able to constitutively activate MAPK and PI3K/PDK1/Akt signalling pathways, seem to be responsible of malignant melanocytic transformation and lead to aberrant cellular physiological processes. Specific regulators and modulators of both signaling pathways may represent promising therapeutic targets to investigate drug resistance typical of BRAF-inhibitors such as Dabrafenib. We developed a continuous Petri Net model that simulates both MAPK and PI3K/PDK1/Akt pathways and their interactions in order to analyze the complex kinase cascades in melanoma and to predict new crucial nodes involved in drug resistance like in the Ras arm.