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2014 | OriginalPaper | Buchkapitel

Models and Optimal Control in Freezing and Thawing of Living Cells and Tissues

verfasst von : Karl-Heinz Hoffmann, Nikolai D. Botkin, Varvara L. Turova

Erschienen in: Trends in PDE Constrained Optimization

Verlag: Springer International Publishing

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Abstract

This paper outlines results obtained by the authors in the framework of the DFG Priority Program “Optimization with partial differential equations” (SPP 1253). The intention of the authors was related to the application of the theory of partial differential equations and optimal control techniques to the minimization of damaging factors in cryopreservation of living cells and tissues in order to increase the survival rate of frozen and subsequently thawed out cells. The paper presents mathematical models of the processes of freezing and thawing and describes the application of optimal control theory to the design of optimal cooling and warming protocols which reduce damaging effects and improve the survival rate of cells.

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Metadaten
Titel
Models and Optimal Control in Freezing and Thawing of Living Cells and Tissues
verfasst von
Karl-Heinz Hoffmann
Nikolai D. Botkin
Varvara L. Turova
Copyright-Jahr
2014
DOI
https://doi.org/10.1007/978-3-319-05083-6_10