Skip to main content
Erschienen in: International Journal of Computer Assisted Radiology and Surgery 4/2013

01.07.2013 | Original Article

Multimodality GPU-based computer-assisted diagnosis of breast cancer using ultrasound and digital mammography images

verfasst von: Konstantinos P. Sidiropoulos, Spiros A. Kostopoulos, Dimitris T. Glotsos, Emmanouil I. Athanasiadis, Nikos D. Dimitropoulos, John T. Stonham, Dionisis A. Cavouras

Erschienen in: International Journal of Computer Assisted Radiology and Surgery | Ausgabe 4/2013

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Purpose To improve the computer-aided diagnosis of breast lesions, by designing a pattern recognition system (PR-system) on commercial graphics processing unit (GPU) cards using parallel programming and textural information from multimodality imaging.
Material and methods Patients with histologically verified breast lesions underwent both ultrasound (US) and digital mammography (DM), lesions were outlined on the images by an experienced radiologist, and textural features were calculated. The PR-system was designed to provide highest possible precision by programming in parallel the multiprocessors of the NVIDIA’s GPU cards, GeForce 8800GT or 580GTX, and using the CUDA programming framework and C++. The PR-system was built around the probabilistic neural network classifier, and its performance was evaluated by a re-substitution method, for estimating the system’s highest accuracy, and by the external cross-validation method, for assessing the PR-system’s unbiased accuracy to new, “unseen” by the system, data.
Results Classification accuracies for discriminating malignant from benign lesions were as follows: 85.5 % using US-features alone, 82.3 % employing DM features alone, and 93.5 % combining US and DM features. Mean accuracy to new “unseen” data for the combined US and DM features was 81 %. Those classification accuracies were about 10 % higher than accuracies achieved on a single CPU, using sequential programming methods, and 150-fold faster.
Conclusion The proposed PR-system improves breast-lesion discrimination accuracy, it may be redesigned on site when new verified data are incorporated in its depository, and it may serve as a second opinion tool in a clinical environment.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Laine HR, Tukeva T, Mikkola P et al (1996) Assessment of mammography and ultrasound examination in the diagnosis of breast cancer. Eur J Ultrasound 3(1):9–14CrossRef Laine HR, Tukeva T, Mikkola P et al (1996) Assessment of mammography and ultrasound examination in the diagnosis of breast cancer. Eur J Ultrasound 3(1):9–14CrossRef
2.
Zurück zum Zitat Tang J, Rangayyan RM, Xu J et al (2009) Computer-aided detection and diagnosis of breast cancer with mammography: recent advances. IEEE Trans Inf Technol Biomed 13(2):236–251PubMedCrossRef Tang J, Rangayyan RM, Xu J et al (2009) Computer-aided detection and diagnosis of breast cancer with mammography: recent advances. IEEE Trans Inf Technol Biomed 13(2):236–251PubMedCrossRef
3.
Zurück zum Zitat Humphrey LL, Helfand M, Chan BK et al (2002) Breast cancer screening: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med 137((5 Part 1)):347–360PubMedCrossRef Humphrey LL, Helfand M, Chan BK et al (2002) Breast cancer screening: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med 137((5 Part 1)):347–360PubMedCrossRef
4.
Zurück zum Zitat Majid AS, de Paredes ES, Doherty RD et al (2003) Missed breast carcinoma: pitfalls and pearls. Radiographics 23(4):881–895PubMedCrossRef Majid AS, de Paredes ES, Doherty RD et al (2003) Missed breast carcinoma: pitfalls and pearls. Radiographics 23(4):881–895PubMedCrossRef
5.
Zurück zum Zitat Wang X, Lederman D, Tan J et al (2010) Computerized detection of breast tissue asymmetry depicted on bilateral mammograms: a preliminary study of breast risk stratification. Acad Radiol 17(10):1234–1241PubMedCrossRef Wang X, Lederman D, Tan J et al (2010) Computerized detection of breast tissue asymmetry depicted on bilateral mammograms: a preliminary study of breast risk stratification. Acad Radiol 17(10):1234–1241PubMedCrossRef
6.
Zurück zum Zitat Farber R (2011) CUDA application design and development. Morgan Kaufmann, Los Altos, CA Farber R (2011) CUDA application design and development. Morgan Kaufmann, Los Altos, CA
7.
Zurück zum Zitat Evers K (2001) Diagnostic breast imaging. Am J Roentgenol 177(5):1094CrossRef Evers K (2001) Diagnostic breast imaging. Am J Roentgenol 177(5):1094CrossRef
8.
Zurück zum Zitat Harms SE (1999) Technical report of the international working group on breast MRI. J Magn Reson Imaging 10(6):979PubMedCrossRef Harms SE (1999) Technical report of the international working group on breast MRI. J Magn Reson Imaging 10(6):979PubMedCrossRef
9.
Zurück zum Zitat Bird RE, Wallace TW, Yankaskas BC (1992) Analysis of cancers missed at screening mammography. Radiology 184(3):613–617PubMed Bird RE, Wallace TW, Yankaskas BC (1992) Analysis of cancers missed at screening mammography. Radiology 184(3):613–617PubMed
10.
Zurück zum Zitat Beam CA, Layde PM, Sullivan DC (1996) Variability in the interpretation of screening mammograms by US radiologists. Findings from a national sample. Arch Intern Med 156(2):209–213PubMedCrossRef Beam CA, Layde PM, Sullivan DC (1996) Variability in the interpretation of screening mammograms by US radiologists. Findings from a national sample. Arch Intern Med 156(2):209–213PubMedCrossRef
11.
Zurück zum Zitat Sardanelli F, Podo F, D’Agnolo G et al (2007) Multicenter comparative multimodality surveillance of women at genetic-familial high risk for breast cancer (HIBCRIT study): interim results. Radiology 242(3):698–715PubMedCrossRef Sardanelli F, Podo F, D’Agnolo G et al (2007) Multicenter comparative multimodality surveillance of women at genetic-familial high risk for breast cancer (HIBCRIT study): interim results. Radiology 242(3):698–715PubMedCrossRef
12.
Zurück zum Zitat Lee JM, Halpern EF, Rafferty EA et al (2009) Evaluating the correlation between film mammography and MRI for screening women with increased breast cancer risk. Acad Radiol 16(11):1323–1328PubMedCrossRef Lee JM, Halpern EF, Rafferty EA et al (2009) Evaluating the correlation between film mammography and MRI for screening women with increased breast cancer risk. Acad Radiol 16(11):1323–1328PubMedCrossRef
13.
Zurück zum Zitat Houssami N, Ciatto S (2011) The evolving role of new imaging methods in breast screening. Prev Med 53(3):123–126PubMedCrossRef Houssami N, Ciatto S (2011) The evolving role of new imaging methods in breast screening. Prev Med 53(3):123–126PubMedCrossRef
14.
Zurück zum Zitat Malvindi MA, Greco A, Conversano F et al (2011) Magnetic/silica nanocomposites as dual-mode contrast agents for combined magnetic resonance imaging and ultrasonography. Adv Funct Mater 21(13):2548–2555CrossRef Malvindi MA, Greco A, Conversano F et al (2011) Magnetic/silica nanocomposites as dual-mode contrast agents for combined magnetic resonance imaging and ultrasonography. Adv Funct Mater 21(13):2548–2555CrossRef
15.
Zurück zum Zitat Soloperto G, Conversano F, Greco A et al (2012) Advanced spectral analyses for real-time automatic echographic tissue-typing of simulated tumor masses at different compression stages. IEEE Trans Ultrason Ferroelectr Freq Control 59(12):2692–2701PubMedCrossRef Soloperto G, Conversano F, Greco A et al (2012) Advanced spectral analyses for real-time automatic echographic tissue-typing of simulated tumor masses at different compression stages. IEEE Trans Ultrason Ferroelectr Freq Control 59(12):2692–2701PubMedCrossRef
16.
Zurück zum Zitat Yuan Y, Giger ML, Li H et al (2010) Multimodality computer-aided breast cancer diagnosis with FFDM and DCE-MRI. Acad Radiol 17(9):1158–1167PubMedCrossRef Yuan Y, Giger ML, Li H et al (2010) Multimodality computer-aided breast cancer diagnosis with FFDM and DCE-MRI. Acad Radiol 17(9):1158–1167PubMedCrossRef
17.
Zurück zum Zitat Drukker K, Horsch K, Giger ML (2005) Multimodality computerized diagnosis of breast lesions using mammography and sonography. Acad Radiol 12(8):970–979PubMedCrossRef Drukker K, Horsch K, Giger ML (2005) Multimodality computerized diagnosis of breast lesions using mammography and sonography. Acad Radiol 12(8):970–979PubMedCrossRef
18.
Zurück zum Zitat Sahiner B, Chan HP, Hadjiiski LM et al (2009) Multi-modality CADx: ROC study of the effect on radiologists’ accuracy in characterizing breast masses on mammograms and 3D ultrasound images. Acad Radiol 16(7):810–818PubMedCrossRef Sahiner B, Chan HP, Hadjiiski LM et al (2009) Multi-modality CADx: ROC study of the effect on radiologists’ accuracy in characterizing breast masses on mammograms and 3D ultrasound images. Acad Radiol 16(7):810–818PubMedCrossRef
19.
Zurück zum Zitat Horsch K, Giger ML, Vyborny CJ et al (2006) Classification of breast lesions with multimodality computer-aided diagnosis: observer study results on an independent clinical data set. Radiology 240(2):357–368PubMedCrossRef Horsch K, Giger ML, Vyborny CJ et al (2006) Classification of breast lesions with multimodality computer-aided diagnosis: observer study results on an independent clinical data set. Radiology 240(2):357–368PubMedCrossRef
20.
Zurück zum Zitat Theodoridis S, Koutroumbas K (2008) Pattern recognition, 4th edn. Academic Press, San Diego Theodoridis S, Koutroumbas K (2008) Pattern recognition, 4th edn. Academic Press, San Diego
21.
Zurück zum Zitat Xu F, Mueller K (2007) Real-time 3D computed tomographic reconstruction using commodity graphics hardware. Phys Med Biol 52(12):3405–3419PubMedCrossRef Xu F, Mueller K (2007) Real-time 3D computed tomographic reconstruction using commodity graphics hardware. Phys Med Biol 52(12):3405–3419PubMedCrossRef
22.
Zurück zum Zitat Ruiz A, Sertel O, Ujaldon M et al (2009) Stroma classification for neuroblastoma on graphics processors. Int J Data Min Bioinform 3(3):280–298PubMedCrossRef Ruiz A, Sertel O, Ujaldon M et al (2009) Stroma classification for neuroblastoma on graphics processors. Int J Data Min Bioinform 3(3):280–298PubMedCrossRef
23.
Zurück zum Zitat Lapeer RJ, Shah SK, Rowland RS (2010) An optimised radial basis function algorithm for fast non-rigid registration of medical images. Comput Biol Med 40(1):1–7PubMedCrossRef Lapeer RJ, Shah SK, Rowland RS (2010) An optimised radial basis function algorithm for fast non-rigid registration of medical images. Comput Biol Med 40(1):1–7PubMedCrossRef
24.
Zurück zum Zitat Shams R, Sadeghi P, Kennedy R et al (2010) Parallel computation of mutual information on the GPU with application to real-time registration of 3D medical images. Comput Methods Programs Biomed 99(2):133–146PubMedCrossRef Shams R, Sadeghi P, Kennedy R et al (2010) Parallel computation of mutual information on the GPU with application to real-time registration of 3D medical images. Comput Methods Programs Biomed 99(2):133–146PubMedCrossRef
25.
Zurück zum Zitat Dai Y, Tian J, Dong D et al (2010) Real-time visualized freehand 3D ultrasound reconstruction based on GPU. IEEE Trans Inf Technol Biomed 14(6):1338–1345PubMedCrossRef Dai Y, Tian J, Dong D et al (2010) Real-time visualized freehand 3D ultrasound reconstruction based on GPU. IEEE Trans Inf Technol Biomed 14(6):1338–1345PubMedCrossRef
26.
Zurück zum Zitat Sidiropoulos K, Glotsos D, Kostopoulos S et al (2012) Real time decision support system for diagnosis of rare cancers, trained in parallel, on a graphics processing unit. Comput Biol Med 42(4):376–386PubMedCrossRef Sidiropoulos K, Glotsos D, Kostopoulos S et al (2012) Real time decision support system for diagnosis of rare cancers, trained in parallel, on a graphics processing unit. Comput Biol Med 42(4):376–386PubMedCrossRef
27.
Zurück zum Zitat Kirk DB, W-mW Hwu (2010) Programming massively parallel processors: a hands-on approach. Morgan Kaufmann, Amsterdam Kirk DB, W-mW Hwu (2010) Programming massively parallel processors: a hands-on approach. Morgan Kaufmann, Amsterdam
28.
Zurück zum Zitat BI-RADS Breast Imaging Reporting and Data System Breast Imaging Atlas (2003) American College of Radiology. Reston, VA BI-RADS Breast Imaging Reporting and Data System Breast Imaging Atlas (2003) American College of Radiology. Reston, VA
29.
Zurück zum Zitat Haralick RM, Shanmugam K, Dinstein IH (1973) Textural features for image classification. IEEE Trans Sys Man Cyb 3:610–621CrossRef Haralick RM, Shanmugam K, Dinstein IH (1973) Textural features for image classification. IEEE Trans Sys Man Cyb 3:610–621CrossRef
30.
Zurück zum Zitat Galloway MM (1975) Texture analysis using gray-level run lengths. Comput Graph Image Process 4:172–179CrossRef Galloway MM (1975) Texture analysis using gray-level run lengths. Comput Graph Image Process 4:172–179CrossRef
31.
Zurück zum Zitat Gose E, Johnsonbaugh R, Jost S (1996) Pattern recognition and image analysis. Prentice Hall PTR, New Jersey Gose E, Johnsonbaugh R, Jost S (1996) Pattern recognition and image analysis. Prentice Hall PTR, New Jersey
32.
Zurück zum Zitat Gonzalez R, Woods R (2002) Digital image processing. 2nd edn. Addison-Wesley Pub, NY Gonzalez R, Woods R (2002) Digital image processing. 2nd edn. Addison-Wesley Pub, NY
33.
Zurück zum Zitat Specht DF (1990) Probabilistic neural networks. Neural Netw 3:109–118CrossRef Specht DF (1990) Probabilistic neural networks. Neural Netw 3:109–118CrossRef
34.
Zurück zum Zitat Kuncheva LI (2004) Combining pattern classifiers: methods and algorithms. Wiley, Hoboken, NJCrossRef Kuncheva LI (2004) Combining pattern classifiers: methods and algorithms. Wiley, Hoboken, NJCrossRef
35.
Zurück zum Zitat Kecman V (2001) Learning and soft computing: Support vector machines, Neural Networks, and Fuzzy logic models. MIT Press, Cambridge, pp 121–184 Kecman V (2001) Learning and soft computing: Support vector machines, Neural Networks, and Fuzzy logic models. MIT Press, Cambridge, pp 121–184
36.
Zurück zum Zitat Gunal S, Gerek ON, Ece DG et al (2009) The search for optimal feature set in power quality event classification. Expert Syst Appl 36(7):10266–10273CrossRef Gunal S, Gerek ON, Ece DG et al (2009) The search for optimal feature set in power quality event classification. Expert Syst Appl 36(7):10266–10273CrossRef
37.
Zurück zum Zitat Ambroise C, McLachlan GJ (2002) Selection bias in gene extraction on the basis of microarray gene-expression data. Proc Natl Acad Sci USA 99(10):6562–6566PubMedCrossRef Ambroise C, McLachlan GJ (2002) Selection bias in gene extraction on the basis of microarray gene-expression data. Proc Natl Acad Sci USA 99(10):6562–6566PubMedCrossRef
38.
Zurück zum Zitat Romero E, Sopena JM (2008) Performing feature selection with multilayer perceptrons. IEEE Trans Neural Netw 19(3):431–441PubMedCrossRef Romero E, Sopena JM (2008) Performing feature selection with multilayer perceptrons. IEEE Trans Neural Netw 19(3):431–441PubMedCrossRef
39.
Zurück zum Zitat Ahmed N, Rao KR (1975) Orthogonal transforms for digital signal processing. Springer, BerlinCrossRef Ahmed N, Rao KR (1975) Orthogonal transforms for digital signal processing. Springer, BerlinCrossRef
40.
Zurück zum Zitat Oh K-S, Jung K (2004) GPU implementation of neural networks. Pattern Recognit 37(6):1311–1314CrossRef Oh K-S, Jung K (2004) GPU implementation of neural networks. Pattern Recognit 37(6):1311–1314CrossRef
41.
Zurück zum Zitat Beliakov G, Li G (2012) Improving the speed and stability of the k-nearest neighbors method. Pattern Recognit Lett 33(10):1296–1301CrossRef Beliakov G, Li G (2012) Improving the speed and stability of the k-nearest neighbors method. Pattern Recognit Lett 33(10):1296–1301CrossRef
42.
Zurück zum Zitat Pang WM, Qin J, Lu Y et al (2011) Accelerating simultaneous algebraic reconstruction technique with motion compensation using CUDA-enabled GPU. Int J Comput Assist Radiol Surg 6(2):187–199PubMedCrossRef Pang WM, Qin J, Lu Y et al (2011) Accelerating simultaneous algebraic reconstruction technique with motion compensation using CUDA-enabled GPU. Int J Comput Assist Radiol Surg 6(2):187–199PubMedCrossRef
43.
Zurück zum Zitat Santhanam AP, Min Y, Neelakkantan H et al (2012) A multi-GPU real-time dose simulation software framework for lung radiotherapy. Int J Comput Assist Radiol Surg 7(5):705–719PubMedCrossRef Santhanam AP, Min Y, Neelakkantan H et al (2012) A multi-GPU real-time dose simulation software framework for lung radiotherapy. Int J Comput Assist Radiol Surg 7(5):705–719PubMedCrossRef
44.
Zurück zum Zitat Foley D (1972) Considerations of sample and feature size. IEEE Trans Inf Theory 18(5):618–626CrossRef Foley D (1972) Considerations of sample and feature size. IEEE Trans Inf Theory 18(5):618–626CrossRef
45.
Zurück zum Zitat Karahaliou AN, Boniatis IS, Skiadopoulos SG et al (2008) Breast cancer diagnosis: analyzing texture of tissue surrounding microcalcifications. IEEE Trans Inf Technol Biomed 12(6):731–738PubMedCrossRef Karahaliou AN, Boniatis IS, Skiadopoulos SG et al (2008) Breast cancer diagnosis: analyzing texture of tissue surrounding microcalcifications. IEEE Trans Inf Technol Biomed 12(6):731–738PubMedCrossRef
Metadaten
Titel
Multimodality GPU-based computer-assisted diagnosis of breast cancer using ultrasound and digital mammography images
verfasst von
Konstantinos P. Sidiropoulos
Spiros A. Kostopoulos
Dimitris T. Glotsos
Emmanouil I. Athanasiadis
Nikos D. Dimitropoulos
John T. Stonham
Dionisis A. Cavouras
Publikationsdatum
01.07.2013
Verlag
Springer Berlin Heidelberg
Erschienen in
International Journal of Computer Assisted Radiology and Surgery / Ausgabe 4/2013
Print ISSN: 1861-6410
Elektronische ISSN: 1861-6429
DOI
https://doi.org/10.1007/s11548-013-0813-y

Weitere Artikel der Ausgabe 4/2013

International Journal of Computer Assisted Radiology and Surgery 4/2013 Zur Ausgabe