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Erschienen in:
Nonautonomous Dynamical Systems in the Life Sciences Kapitel lesen Erstes Kapitel lesen

2013 | OriginalPaper | Buchkapitel

6. Multisite Mechanisms for Ultrasensitivity in Signal Transduction

verfasst von : Germán A. Enciso

Erschienen in: Nonautonomous Dynamical Systems in the Life Sciences

Verlag: Springer International Publishing

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Abstract

One of the key aspects in the study of cellular communication is understanding how cells receive a continuous input and transform it into a discrete, all-or-none output. Such so-called ultrasensitive dose responses can also be used in a variety of other contexts, from the efficient transport of oxygen in the blood to the regulation of the cell cycle and gene expression. This chapter provides a self contained mathematical review of the most important molecular models of ultrasensitivity in the literature, with an emphasis on mechanisms involving multisite modifications. The models described include two deeply influential systems based on allosteric behavior, the MWC and the KNF models. Also included is a description of more recent work by the author and colleagues of novel mechanisms using alternative hypotheses to create ultrasensitive behavior.

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Vorheriges Kapitel Coupled Nonautonomous Oscillators
Nächstes Kapitel Mathematical Concepts in Pharmacokinetics and Pharmacodynamics with Application to Tumor Growth
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Metadaten
Titel
Multisite Mechanisms for Ultrasensitivity in Signal Transduction
verfasst von
Germán A. Enciso
Copyright-Jahr
2013
Buch
Nonautonomous Dynamical Systems in the Life Sciences

Print ISBN: 978-3-319-03079-1

Electronic ISBN: 978-3-319-03080-7

Copyright-Jahr: 2013

DOI
https://doi.org/10.1007/978-3-319-03080-7_6