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Erschienen in:
1990 | OriginalPaper | Buchkapitel
Mutation and Transformation
verfasst von : Professor Dr. Jürgen Kiefer
Erschienen in: Biological Radiation Effects
Verlag: Springer Berlin Heidelberg
Enthalten in: Professional Book Archive
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This chapter deals with genetic alterations at the cellular level. At the beginning the general fundamental questions and techniques are discussed followed by an outline of experiments in bacteria where the relation to repair processes is well understood. Investigations with mammalian cells are treated in more detail (dependence of radiation quality and cell cycle stages etc). A comparison of different systems shows that mutation frequencies per unit dose increases with DNA content which has consequences for the interpretation of mechanisms. The very important technique of in vitro neoplastic transformation and some results obtained are introduced in the last section.