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Abstract
Gold and silver that are beautiful and resistant to water and air were always fascinating for people. Metals and noble metals remain important even in the present ages of wood, polymer, carbon, and silicon. Different pathways have been proposed for the preparation of noble metal nanoparticles with tailor-made size and shape in the present decades. The nanometer regime covers the transition from condensed matter behavior to atomic and molecular properties and thus is a very rich but also very demanding area in materials science. Decreasing the dimension of nanoparticles has pronounced effect on the physical properties that significantly differ from the bulk material. They represent the missing link between metal atoms and microparticles. The role of interfaces is rapidly increasing in science and nanotechnology and they are the key to new functions. Separation and purification techniques play important role in separation of the nanomaterials (NMs) and their conjugates from the original reactants and by-products. Characterization includes assessment of composition, morphology, dimensionality, and physical and chemical properties. Size, volume, aspect ratio, perimeter, projected area, surface roughness, etc., are typical morphology parameters that are assessed. A variety of well-developed techniques which already have been successfully applied to the characterization of bare NMs are now being extended to examining NM-conjugates. These include separation-based, scattering, microscopy, spectroscopy, mass spectroscopy, and thermal techniques. Dialysis, filtration, extraction, and differential precipitation represent the most common methods applied to nanoparticle-(bio)conjugate purification. Chemical extraction and differential precipitation are other potentially efficient but largely underused purification techniques. Top-down approaches, such as photolithography, e-beam lithography (EBL), and Focused ion beam (FIB), offer high fidelity and high controllability in terms of design and prediction. Some bottom-up approaches based on self-assembly can produce high-resolution (sub)nanostructures over a large area with a low cost. The utilization of spectroscopic techniques for the detection of cancerous and precancerous lesions is based on the analysis of specific light-tissue interactions to assess the state of biological tissue. As light illuminates the targeted tissue, these biomolecules, termed fluorophores, absorb the energy in the illuminating light and respond by emitting fluorescent light of lower energy (and longer wavelength). Advances in bioengineering and the continued refinement of optical detection techniques have led to the development of multimodal optical detection systems. The ultimate goal of the optical detection systems centers on the achievement of an “optical biopsy.” Nanotechnology is increasingly gaining a foothold in clinical medicine, especially in oncology. The fabrication of nanodevices as probes is complex, most likely the assembly of building blocks including nanoparticles, nanowires, nanotubes, and substrates.
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generally refers to a measurable indicator of some biological state or condition. The term is also occasionally used to refer to a substance the presence of which indicates the existence of a living organism.
Fluorophore (or fluorochrome, similarly to a chromophore)
is a fluorescent chemical compound that can re-emit light upon light excitation. Fluorophores typically contain several combined aromatic groups, or planar or cyclic molecules with several π bonds.
Immunodeficiency (or immune deficiency)
is a state in which the immune system’s ability to fight infectious disease and cancer is compromised or entirely absent.
Monoclonal antibodies (mAb or moAb)
are antibodies that are made by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies can have monovalent affinity, in that they bind to the same epitope (the part of an antigen that is recognized by the antibody).
Non-Hodgkin lymphoma (sometimes called NHL, or just lymphoma)
is a cancer that starts in cells called lymphocytes, which are part of the body’s immune system.
Photothermal therapy (PTT)
refers to efforts to use electromagnetic radiation (most often in infrared wavelengths) for the treatment of various medical conditions, including cancer. This approach is an extension of photodynamic therapy, in which a photosensitizer is excited with specific band light. This activation brings the sensitizer to an excited state, where it then releases vibrational energy (heat), which is what kills the targeted cells.
Premalignant (precancerous) lesions
are morphologically atypical tissue which appears abnormal under microscopic examination, in which cancer is more likely to occur than in its apparently normal counterpart.
Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen.