Skip to main content
Erschienen in: Journal of Nanoparticle Research 4/2013

01.04.2013 | Review

Nanomedicine highlights in atherosclerosis

verfasst von: Varvara Karagkiozaki

Erschienen in: Journal of Nanoparticle Research | Ausgabe 4/2013

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Atherosclerosis is a multifactorial disease and many different approaches have been attempted for its accurate diagnosis and treatment. The disease is induced by a low-grade inflammatory process in the vascular wall, leading through a cascade of events to the eventual formation of atheromatous plaque and arterial stenosis. Different types of cells participate in the process making more difficult to recognize the potential cellular targets within the plaques for their effective treatment. The rise of nanomedicine over the last decade has provided new types of drug delivery nanosystems that are able to be delivered to a specific diseased site of the vessel for imaging while simultaneously act as therapeutic agents. In this paper, a review of the recent advances in nanomedicine that has provided novel insights to the disease diagnosis and treatment will be given in line with different nanotechnology-based approaches to advance the cardiovascular stents. The main complications of bare metal stents such as restenosis and of drug-eluting stents which is the late stent thrombosis are analyzed to comprehend the demand for emerging therapeutic strategies based on nanotechnology.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Literatur
Zurück zum Zitat Aggarwal P, Hall JB, McLeland CB, Dobrovolskaia M, McNeil SE (2009) Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. Adv Drug Deliv Rev 61:428–437. doi:10.1016/j.addr.2009.03.009 CrossRef Aggarwal P, Hall JB, McLeland CB, Dobrovolskaia M, McNeil SE (2009) Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. Adv Drug Deliv Rev 61:428–437. doi:10.​1016/​j.​addr.​2009.​03.​009 CrossRef
Zurück zum Zitat Alfonso F (2009) Treatment of In-stent Restenosis—Past, Present and Future. Eur Cardiol 5:74–78 Alfonso F (2009) Treatment of In-stent Restenosis—Past, Present and Future. Eur Cardiol 5:74–78
Zurück zum Zitat Babu RV, Mallikarjun V, Nikhat SR, Srikanth G, Theoharis S, Krueger U et al (2009) Targeting gene delivery to activated vascular endothelium using anti e/p-selectin antibody linked to PAMAM dendrimers. J Immunol Meth 343:79–90. doi:10.1016/j.jim.2008.12.005 CrossRef Babu RV, Mallikarjun V, Nikhat SR, Srikanth G, Theoharis S, Krueger U et al (2009) Targeting gene delivery to activated vascular endothelium using anti e/p-selectin antibody linked to PAMAM dendrimers. J Immunol Meth 343:79–90. doi:10.​1016/​j.​jim.​2008.​12.​005 CrossRef
Zurück zum Zitat Banquy X, Leclair G, Rabanel JM, Argaw A, Bouchard J-Fo, Hildgen P, Giasson S (2008) Selectins ligand decorated drug carriers for activated endothelial cell targeting. J Bioconjug Chem 19:2030–2039. doi:10.1021/bc800257m CrossRef Banquy X, Leclair G, Rabanel JM, Argaw A, Bouchard J-Fo, Hildgen P, Giasson S (2008) Selectins ligand decorated drug carriers for activated endothelial cell targeting. J Bioconjug Chem 19:2030–2039. doi:10.​1021/​bc800257m CrossRef
Zurück zum Zitat Bhargava B, Reddy K, Karthikeyan G, Raju R, Mishra S, Singh S (2006) A novel paclitaxel-eluting porous carbon–carbon NP coated nonpolymeric cobalt–chromium stent: evaluation in a porcine model. J Cath Cardiovasc Interv 67:698–702. doi:10.1002/ccd.20698 CrossRef Bhargava B, Reddy K, Karthikeyan G, Raju R, Mishra S, Singh S (2006) A novel paclitaxel-eluting porous carbon–carbon NP coated nonpolymeric cobalt–chromium stent: evaluation in a porcine model. J Cath Cardiovasc Interv 67:698–702. doi:10.​1002/​ccd.​20698 CrossRef
Zurück zum Zitat Briley-Saebo KC, Johansson LO, Hustvedt SO, Haldorsen AG, Bjornerud A, Fayad ZA, Ahlstrom HK (2006) Clearance of iron oxide particles in rat liver—effect of hydrated particle size and coating material on liver metabolism. Invest Radiol 41:560–571. doi:10.1097/01.rli.0000221321.90261.09 CrossRef Briley-Saebo KC, Johansson LO, Hustvedt SO, Haldorsen AG, Bjornerud A, Fayad ZA, Ahlstrom HK (2006) Clearance of iron oxide particles in rat liver—effect of hydrated particle size and coating material on liver metabolism. Invest Radiol 41:560–571. doi:10.​1097/​01.​rli.​0000221321.​90261.​09 CrossRef
Zurück zum Zitat Burtea C, Ballet S, Laurent S, Rousseaux O, Dencausse A, Gonzalez W et al (2012) Development of a magnetic resonance imaging protocol for the characterization of atherosclerotic plaque by using vascular cell adhesion molecule-1 and apoptosis-targeted ultrasmall superparamagnetic iron oxide derivatives. Arterioscler Thromb Vasc Biol 32:e36–e48. doi:10.1161/ATVBAHA.112.245415 CrossRef Burtea C, Ballet S, Laurent S, Rousseaux O, Dencausse A, Gonzalez W et al (2012) Development of a magnetic resonance imaging protocol for the characterization of atherosclerotic plaque by using vascular cell adhesion molecule-1 and apoptosis-targeted ultrasmall superparamagnetic iron oxide derivatives. Arterioscler Thromb Vasc Biol 32:e36–e48. doi:10.​1161/​ATVBAHA.​112.​245415 CrossRef
Zurück zum Zitat Caruthers SD, Cyrus T, Winter PM, Wickline SA, Lanza GM M (2009) Anti-angiogenic perfluorocarbon nanoparticles for diagnosis and treatment of atherosclerosis. Nanomed Nanobiotechnol 3:11–23. doi:10.1002/wnan.9 Caruthers SD, Cyrus T, Winter PM, Wickline SA, Lanza GM M (2009) Anti-angiogenic perfluorocarbon nanoparticles for diagnosis and treatment of atherosclerosis. Nanomed Nanobiotechnol 3:11–23. doi:10.​1002/​wnan.​9
Zurück zum Zitat Chaw CS, Chooi KW, Liu XM, Tan CW, Wang L, Yang YY (2004) Thermally responsive core-shell nanoparticles self-assembled from cholesteryl end-capped and grafted polyacrylamides: drug incorporation and in vitro release. Biomaterials 25:4297–4308. doi:10.1016/j.biomaterials.2003.10.095 CrossRef Chaw CS, Chooi KW, Liu XM, Tan CW, Wang L, Yang YY (2004) Thermally responsive core-shell nanoparticles self-assembled from cholesteryl end-capped and grafted polyacrylamides: drug incorporation and in vitro release. Biomaterials 25:4297–4308. doi:10.​1016/​j.​biomaterials.​2003.​10.​095 CrossRef
Zurück zum Zitat Choi HS, Ashitate Y, Lee JH, Kim SH, Matsui A, Insin N, Bawendi MG, Semmler-Behnke M, Frangioni JV, Tsuda A (2010) Rapid translocation of nanoparticles from the lung airspaces to the body. Nat Biotech 28:1300–1303. doi:10.1038/nbt.1696 CrossRef Choi HS, Ashitate Y, Lee JH, Kim SH, Matsui A, Insin N, Bawendi MG, Semmler-Behnke M, Frangioni JV, Tsuda A (2010) Rapid translocation of nanoparticles from the lung airspaces to the body. Nat Biotech 28:1300–1303. doi:10.​1038/​nbt.​1696 CrossRef
Zurück zum Zitat Chorny M, Fishbein Yellen BB, Alferiev IS, Bakay M, Ganta S, Adamo R et al (2010) Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields. Proc Natl Acad Sci USA 107:8346–8351. doi:10.1073/pnas.0909506107 CrossRef Chorny M, Fishbein Yellen BB, Alferiev IS, Bakay M, Ganta S, Adamo R et al (2010) Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields. Proc Natl Acad Sci USA 107:8346–8351. doi:10.​1073/​pnas.​0909506107 CrossRef
Zurück zum Zitat Cyrus T, Zhang H, Allen JS, Williams TA, Hu G, Caruthers SD, Wickline SA, Lanza GM (2008) Intramural delivery of rapamycin with alphavbeta3-targeted paramagnetic nanoparticles inhibits stenosis after balloon injury. Arterioscler Thromb Vasc Biol 28:820–826. doi:10.1161/ATVBAHA.107.156281 CrossRef Cyrus T, Zhang H, Allen JS, Williams TA, Hu G, Caruthers SD, Wickline SA, Lanza GM (2008) Intramural delivery of rapamycin with alphavbeta3-targeted paramagnetic nanoparticles inhibits stenosis after balloon injury. Arterioscler Thromb Vasc Biol 28:820–826. doi:10.​1161/​ATVBAHA.​107.​156281 CrossRef
Zurück zum Zitat De Graaf J, Hak-Lemmers HL, Hectors MP, Demacker PN et al (1991) Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects. Arterioscler Thromb Vasc Biol 11:298–306. doi:10.1161/01.ATV.11.2.298 CrossRef De Graaf J, Hak-Lemmers HL, Hectors MP, Demacker PN et al (1991) Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects. Arterioscler Thromb Vasc Biol 11:298–306. doi:10.​1161/​01.​ATV.​11.​2.​298 CrossRef
Zurück zum Zitat Deosarkar SP, Malgor R, Fu J, Kohn LD, Hanes J, Goetz DJ (2008) Polymeric particles conjugated with a ligand to VCAM-1 exhibit selective avid and focal adhesion to sites of atherosclerosis. J Biotechnol Bioeng 101:400–752. doi:10.1002/bit.21885 CrossRef Deosarkar SP, Malgor R, Fu J, Kohn LD, Hanes J, Goetz DJ (2008) Polymeric particles conjugated with a ligand to VCAM-1 exhibit selective avid and focal adhesion to sites of atherosclerosis. J Biotechnol Bioeng 101:400–752. doi:10.​1002/​bit.​21885 CrossRef
Zurück zum Zitat Finn A, Nakazawa G, Ladich E, Kolodgie F, Virmani R (2008) Does underlying plaque morphology play a role in vessel healing after drug-eluting stent implantation? J Am Coll Cardiol Imaging 1:485–488. doi:10.1016/j.jcmg.2008.04.007 Finn A, Nakazawa G, Ladich E, Kolodgie F, Virmani R (2008) Does underlying plaque morphology play a role in vessel healing after drug-eluting stent implantation? J Am Coll Cardiol Imaging 1:485–488. doi:10.​1016/​j.​jcmg.​2008.​04.​007
Zurück zum Zitat Frias JC, Williams KJ, Fisher EA, Fayad ZA (2004) Recombinant HDL-like nanoparticles: a specific contrast agent for MRI of atherosclerotic plaques. J Am Chem Soc 126:16316-7. doi:10.1021/ja044911a Frias JC, Williams KJ, Fisher EA, Fayad ZA (2004) Recombinant HDL-like nanoparticles: a specific contrast agent for MRI of atherosclerotic plaques. J Am Chem Soc 126:16316-7. doi:10.​1021/​ja044911a
Zurück zum Zitat Genders TS, Meijboom WB, Meijs MFL, Schuijf JD, Mollet NR, Weustink AC, Pugliese F, Bax JJ, Cramer MJ et al (2009) CT coronary angiography in patients suspected of having coronary artery disease: decision making from various perspectives in the face of uncertainty. Radiology 253:734–744. doi:10.1148/radiol.2533090507 CrossRef Genders TS, Meijboom WB, Meijs MFL, Schuijf JD, Mollet NR, Weustink AC, Pugliese F, Bax JJ, Cramer MJ et al (2009) CT coronary angiography in patients suspected of having coronary artery disease: decision making from various perspectives in the face of uncertainty. Radiology 253:734–744. doi:10.​1148/​radiol.​2533090507 CrossRef
Zurück zum Zitat Hildebrandt N, Hermsdorf D, Signorell R, Schmitz SA, Diederichsena U (2007) Superparamagnetic iron oxide nanoparticles functionalized with peptides by electrostatic interactions. Arkivoc (v): 79–90. doi:10.1039/B406193D Hildebrandt N, Hermsdorf D, Signorell R, Schmitz SA, Diederichsena U (2007) Superparamagnetic iron oxide nanoparticles functionalized with peptides by electrostatic interactions. Arkivoc (v): 79–90. doi:10.​1039/​B406193D
Zurück zum Zitat Hoshino A, Fujioka K, Oku T et al (2004) Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Lett 4:2163–3163. doi:10.1021/nl048715d CrossRef Hoshino A, Fujioka K, Oku T et al (2004) Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Lett 4:2163–3163. doi:10.​1021/​nl048715d CrossRef
Zurück zum Zitat Inoue T, Croce K, Morooka T, Sakuma M, Node K, Simon DI (2011) Vascular inflammation and repair. Implications for re-endothelialization, restenosis, and stent thrombosis. J Am Coll Cardiol 10:1057–1066. doi:10.1016/j.jcin.2011.05.025 Inoue T, Croce K, Morooka T, Sakuma M, Node K, Simon DI (2011) Vascular inflammation and repair. Implications for re-endothelialization, restenosis, and stent thrombosis. J Am Coll Cardiol 10:1057–1066. doi:10.​1016/​j.​jcin.​2011.​05.​025
Zurück zum Zitat Joner M, Morimoto K, Kasukawa H, Steigerwald K, Merl S et al (2008) Site-specific targeting of nanoparticle prednisolone reduces in-stent restenosis in a rabbit model of established atheroma. Arterioscler Thromb Vasc Biol 28:1960–1966. doi:10.1161/ATVBAHA.108.170662 CrossRef Joner M, Morimoto K, Kasukawa H, Steigerwald K, Merl S et al (2008) Site-specific targeting of nanoparticle prednisolone reduces in-stent restenosis in a rabbit model of established atheroma. Arterioscler Thromb Vasc Biol 28:1960–1966. doi:10.​1161/​ATVBAHA.​108.​170662 CrossRef
Zurück zum Zitat Joo J, Nam HY, Nam SH, Baek I, Park JS (2009) A novel deposition method of plga nanoparticles on coronary stents. Bull Korean Chem Soc 30:1085–1087CrossRef Joo J, Nam HY, Nam SH, Baek I, Park JS (2009) A novel deposition method of plga nanoparticles on coronary stents. Bull Korean Chem Soc 30:1085–1087CrossRef
Zurück zum Zitat Kang HW, Josephson L, Petrovsky A, Weissleder R, Bogdanov A (2002) Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture. Bioconjug Chem 13:122–127. doi:10.1021/bc0155521 CrossRef Kang HW, Josephson L, Petrovsky A, Weissleder R, Bogdanov A (2002) Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture. Bioconjug Chem 13:122–127. doi:10.​1021/​bc0155521 CrossRef
Zurück zum Zitat Karagkiozaki V, Logothetidis S, Lousinian S, Giannoglou G (2008) Impact of surface electric properties of carbon-based thin films on platelets activation for nano-medical and nano-sensing applications. J Int Nanomed 3:461–469. doi:http://dx.doi.org/10.2147/IJN.S3607 Karagkiozaki V, Logothetidis S, Lousinian S, Giannoglou G (2008) Impact of surface electric properties of carbon-based thin films on platelets activation for nano-medical and nano-sensing applications. J Int Nanomed 3:461–469. doi:http://​dx.​doi.​org/​10.​2147/​IJN.​S3607
Zurück zum Zitat Karagkiozaki V, Logothetidis S, Kalfagiannis N, Lousinian S, Giannoglou G (2009) AFM probing platelets activation behavior on titanium nitride nanocoatings for biomedical applications. J Nanomed 5:64–72. doi:10.1016/j.nano.2008.07.005 Karagkiozaki V, Logothetidis S, Kalfagiannis N, Lousinian S, Giannoglou G (2009) AFM probing platelets activation behavior on titanium nitride nanocoatings for biomedical applications. J Nanomed 5:64–72. doi:10.​1016/​j.​nano.​2008.​07.​005
Zurück zum Zitat Karagkiozaki V, Karagiannidis P, Kalfagiannis N, Kavatzikidou P, Patsalas P, Georgiou D, Logothetidis S (2012a) Novel nanostructured biomaterials: implications for coronary stent thrombosis. Int J Nanomed 7:6063–6076. doi:10.2147/IJN.S34320 Karagkiozaki V, Karagiannidis P, Kalfagiannis N, Kavatzikidou P, Patsalas P, Georgiou D, Logothetidis S (2012a) Novel nanostructured biomaterials: implications for coronary stent thrombosis. Int J Nanomed 7:6063–6076. doi:10.​2147/​IJN.​S34320
Zurück zum Zitat Karagkiozaki V, Vavoulidis E, Karagiannidis PG, Gioti M, Fatouros DG, Vizirianakis IS, Logothetidis S (2012b) Development of a nanoporous and multilayer drug-delivery platform for medical implants. Int J Nanomed 7: 5327–38. doi:http://dx.doi.org/10.2147/IJN.S31185 Karagkiozaki V, Vavoulidis E, Karagiannidis PG, Gioti M, Fatouros DG, Vizirianakis IS, Logothetidis S (2012b) Development of a nanoporous and multilayer drug-delivery platform for medical implants. Int J Nanomed 7: 5327–38. doi:http://​dx.​doi.​org/​10.​2147/​IJN.​S31185
Zurück zum Zitat Karagkiozaki V, Vavoulidis E, Logothetidis S (2012c) Nanomedicine pillars and monitoring nanobiointeractions. In: Logothetidis S (ed) Nanomedicine and nanobiotechnology, 1st edn. Springer-Verlag, Berlin Heidelberg, pp 27–52CrossRef Karagkiozaki V, Vavoulidis E, Logothetidis S (2012c) Nanomedicine pillars and monitoring nanobiointeractions. In: Logothetidis S (ed) Nanomedicine and nanobiotechnology, 1st edn. Springer-Verlag, Berlin Heidelberg, pp 27–52CrossRef
Zurück zum Zitat Kolodgie FD, John M, Khurana C, Farb A, Wilson PS, Acampado E et al (2002) Sustained reduction of in-stent neointimal growth with the use of a novel systemic nanoparticle paclitaxel. Circulation 106:1195–1198. doi:10.1161/01 CrossRef Kolodgie FD, John M, Khurana C, Farb A, Wilson PS, Acampado E et al (2002) Sustained reduction of in-stent neointimal growth with the use of a novel systemic nanoparticle paclitaxel. Circulation 106:1195–1198. doi:10.​1161/​01 CrossRef
Zurück zum Zitat Lanza GM, Yu X, Winter PM, Abendschein DR, Karukstis KK, Scott MJ et al (2002) Targeted antiproliferative drug delivery to vascular smooth muscle cells with a magnetic resonance imaging nanoparticle contrast agent: implications for rational therapy of restenosis. Circulation 106:2842–2847. doi:10.1161/01.CIR.0000044020.27990.32 CrossRef Lanza GM, Yu X, Winter PM, Abendschein DR, Karukstis KK, Scott MJ et al (2002) Targeted antiproliferative drug delivery to vascular smooth muscle cells with a magnetic resonance imaging nanoparticle contrast agent: implications for rational therapy of restenosis. Circulation 106:2842–2847. doi:10.​1161/​01.​CIR.​0000044020.​27990.​32 CrossRef
Zurück zum Zitat Li W, Tutton S, Vu AT, Pierchala L et al (2005) First-pass contrast-enhanced magnetic resonance angiography in humans using ferumoxytol, a novel USPIO-based blood pool agent. J Magn Reson Imaging 21:46–52. doi:10.1002/jmri.20235 CrossRef Li W, Tutton S, Vu AT, Pierchala L et al (2005) First-pass contrast-enhanced magnetic resonance angiography in humans using ferumoxytol, a novel USPIO-based blood pool agent. J Magn Reson Imaging 21:46–52. doi:10.​1002/​jmri.​20235 CrossRef
Zurück zum Zitat Li D, Patel AR, Klibanov AL, Kramer CM, Ruiz M et al (2010) Molecular imaging of atherosclerotic plaques targeted to oxidized LDL receptor LOX-1by SPECT/CT and magnetic resonance. J Circ Cardiovasc Imaging 3:464–472. doi:10.1161/CIRCIMAGING.109.896654 CrossRef Li D, Patel AR, Klibanov AL, Kramer CM, Ruiz M et al (2010) Molecular imaging of atherosclerotic plaques targeted to oxidized LDL receptor LOX-1by SPECT/CT and magnetic resonance. J Circ Cardiovasc Imaging 3:464–472. doi:10.​1161/​CIRCIMAGING.​109.​896654 CrossRef
Zurück zum Zitat Lipinski MJ, Amirbekian V, Frias JC, Aguinaldo JG, Mani V, Briley-Saebo KC, Fuster V, Fallon JT, Fisher EA, Fayad ZA (2006) MRI to detect atherosclerosis with gadolinium-containing immunomicelles targeting the macrophage scavenger receptor. Magn Reson Med 56:601–610. doi:10.1002/mrm.20995 CrossRef Lipinski MJ, Amirbekian V, Frias JC, Aguinaldo JG, Mani V, Briley-Saebo KC, Fuster V, Fallon JT, Fisher EA, Fayad ZA (2006) MRI to detect atherosclerosis with gadolinium-containing immunomicelles targeting the macrophage scavenger receptor. Magn Reson Med 56:601–610. doi:10.​1002/​mrm.​20995 CrossRef
Zurück zum Zitat Lipinski MJ, Frias JC, Amirbekian V, Briley-Saebo KC et al (2009) Macrophage-specific lipid-based nanoparticles improve mri detection and characterization of human atherosclerosis. J Am Coll Cardiol Cardiovasc Imaging 2:637–647. doi:10.1016/j.jcmg.2008.08.009 CrossRef Lipinski MJ, Frias JC, Amirbekian V, Briley-Saebo KC et al (2009) Macrophage-specific lipid-based nanoparticles improve mri detection and characterization of human atherosclerosis. J Am Coll Cardiol Cardiovasc Imaging 2:637–647. doi:10.​1016/​j.​jcmg.​2008.​08.​009 CrossRef
Zurück zum Zitat Liu SQ, Tong YW, Yang YY (2005) Incorporation and in vitro release of doxorubicin in thermally sensitive micelles made from poly(N-isopropylacrylamide co-N, N-dimethylacrylamide)-b-poly(d, l-lactide-coglycolide) with varying compositions. Biomaterials 26:5064–5074CrossRef Liu SQ, Tong YW, Yang YY (2005) Incorporation and in vitro release of doxorubicin in thermally sensitive micelles made from poly(N-isopropylacrylamide co-N, N-dimethylacrylamide)-b-poly(d, l-lactide-coglycolide) with varying compositions. Biomaterials 26:5064–5074CrossRef
Zurück zum Zitat Lobatto ME, Fayad ZA, Silvera S, Vucic E, Calcagno C, Mani V et al (2010) Multimodal clinical imaging to longitudinally assess a nanomedical anti-inflammatory treatment in experimental atherosclerosis. J Mol Pharm 7:2020–2029. doi:10.1021/mp100309y CrossRef Lobatto ME, Fayad ZA, Silvera S, Vucic E, Calcagno C, Mani V et al (2010) Multimodal clinical imaging to longitudinally assess a nanomedical anti-inflammatory treatment in experimental atherosclerosis. J Mol Pharm 7:2020–2029. doi:10.​1021/​mp100309y CrossRef
Zurück zum Zitat Lobatto ME, Fuster V, Fayad ZA, Mulder WJ (2011) Perspectives and opportunities for nanomedicine in the management of atherosclerosis. Nat Rev Drug Discov 10:835–852. doi:10.1038/nrd3578 CrossRef Lobatto ME, Fuster V, Fayad ZA, Mulder WJ (2011) Perspectives and opportunities for nanomedicine in the management of atherosclerosis. Nat Rev Drug Discov 10:835–852. doi:10.​1038/​nrd3578 CrossRef
Zurück zum Zitat Lockman PR, Koziara JM, Mumper RJ, Allen DD (2004) Nanoparticle surface charges alter blood-brain barrier integrity and permeability. J Drug Target 12:635-641. doi:10.1080/10611860400015936 Lockman PR, Koziara JM, Mumper RJ, Allen DD (2004) Nanoparticle surface charges alter blood-brain barrier integrity and permeability. J Drug Target 12:635-641. doi:10.​1080/​1061186040001593​6
Zurück zum Zitat Logothetidis S (2012) Nanomedicine and nanobiotechnology. Springer, Berlin HeidelbergCrossRef Logothetidis S (2012) Nanomedicine and nanobiotechnology. Springer, Berlin HeidelbergCrossRef
Zurück zum Zitat Maguire PD, McLaughlin JA, Okpalugo TIT, Papakonstantinou P, McAdams ET et al (2005) Mechanical stability, corrosion performance and bioresponse of amorphous DLC for medical stents and guidewires. J Diam Relat Mater 14:1277–1288. doi:10.1016/j.diamond.2004.12.023 CrossRef Maguire PD, McLaughlin JA, Okpalugo TIT, Papakonstantinou P, McAdams ET et al (2005) Mechanical stability, corrosion performance and bioresponse of amorphous DLC for medical stents and guidewires. J Diam Relat Mater 14:1277–1288. doi:10.​1016/​j.​diamond.​2004.​12.​023 CrossRef
Zurück zum Zitat Maiseyeu A, Mihai G, Roy S, Kherada N, Simonetti O, Sen C, Sun Q, Parthasarathy S, Rajagopalan S (2010) Detection of macrophages via paramagnetic vesicles incorporating oxidatively tailored cholesterol ester: an approach for atherosclerosis imaging. J Nanomed 5:1341–1356. doi:10.2217/nnm.10.87 CrossRef Maiseyeu A, Mihai G, Roy S, Kherada N, Simonetti O, Sen C, Sun Q, Parthasarathy S, Rajagopalan S (2010) Detection of macrophages via paramagnetic vesicles incorporating oxidatively tailored cholesterol ester: an approach for atherosclerosis imaging. J Nanomed 5:1341–1356. doi:10.​2217/​nnm.​10.​87 CrossRef
Zurück zum Zitat Marambio-Jones C, Hoek E (2010) A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment. J Nanopart Res 12:1531–1551. doi. 10.1007/s11051-010-9900-y Marambio-Jones C, Hoek E (2010) A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment. J Nanopart Res 12:1531–1551. doi. 10.​1007/​s11051-010-9900-y
Zurück zum Zitat McCarthy JR, Korngold E, Weissleder R, Jaffer AF (2010) A light-activated theranostic nanoagent for targeted macrophage ablation in inflammatory atherosclerosis. Small 6:2041–2049. doi:10.1002/smll.201000596 CrossRef McCarthy JR, Korngold E, Weissleder R, Jaffer AF (2010) A light-activated theranostic nanoagent for targeted macrophage ablation in inflammatory atherosclerosis. Small 6:2041–2049. doi:10.​1002/​smll.​201000596 CrossRef
Zurück zum Zitat Monopoli MP, Walczyk D, Campbell A, Elia G, Lynch I, Bombelli FB, Dawson KA (2011) Physical–chemical aspects of protein corona: relevance to in vitro and in vivo biological impacts of nanoparticles. J Am Chem Soc 133:2525–2534. doi:10.1021/ja107583h CrossRef Monopoli MP, Walczyk D, Campbell A, Elia G, Lynch I, Bombelli FB, Dawson KA (2011) Physical–chemical aspects of protein corona: relevance to in vitro and in vivo biological impacts of nanoparticles. J Am Chem Soc 133:2525–2534. doi:10.​1021/​ja107583h CrossRef
Zurück zum Zitat Morris JB, Olzinski AR, Bernard RE, Aravindhan K, Mirabile RC, Boyce R et al (2008) p38 MAPK inhibition reduces aortic ultrasmall superparamagnetic iron oxide uptake in a mouse model of atherosclerosis: mRI assessment. Arterioscler Thromb Vasc Biol 28:265–271. doi:10.1161/ATVBAHA.107.151175 CrossRef Morris JB, Olzinski AR, Bernard RE, Aravindhan K, Mirabile RC, Boyce R et al (2008) p38 MAPK inhibition reduces aortic ultrasmall superparamagnetic iron oxide uptake in a mouse model of atherosclerosis: mRI assessment. Arterioscler Thromb Vasc Biol 28:265–271. doi:10.​1161/​ATVBAHA.​107.​151175 CrossRef
Zurück zum Zitat Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R (2006) Non-invasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. J Circ 114:1504–1511. doi:10.1161/CIRCULATIONAHA.106.646380 CrossRef Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R (2006) Non-invasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. J Circ 114:1504–1511. doi:10.​1161/​CIRCULATIONAHA.​106.​646380 CrossRef
Zurück zum Zitat Nakano K, Egashira K, Masuda S, Funakoshi K, Zhao G, Kimura S et al (2009) Formulation of nanoparticle-eluting stents by a cationic electrodeposition coating technology efficient nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries. J Am Coll Cardiol Interv 2:277–283. doi:10.1016/j.jcin.2008.08.023 Nakano K, Egashira K, Masuda S, Funakoshi K, Zhao G, Kimura S et al (2009) Formulation of nanoparticle-eluting stents by a cationic electrodeposition coating technology efficient nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries. J Am Coll Cardiol Interv 2:277–283. doi:10.​1016/​j.​jcin.​2008.​08.​023
Zurück zum Zitat Nakazawa G, Finn AV, Joner M, Ladich E et al (2008) Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients: an autopsy study. J Circ 118:1138–1145. doi:10.1161/CIRCULATIONAHA.107.762047 CrossRef Nakazawa G, Finn AV, Joner M, Ladich E et al (2008) Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients: an autopsy study. J Circ 118:1138–1145. doi:10.​1161/​CIRCULATIONAHA.​107.​762047 CrossRef
Zurück zum Zitat Pache J, Kastrati A, Mehilli J et al (2003) Intracoronary stenting and angiographic results: strut thickness effect on restenosis outcome (ISAR-STEREO-2) trial. J Am Coll Cardiol 41:1283–1288. doi:10.1016/S0735-1097(03)00119-0 CrossRef Pache J, Kastrati A, Mehilli J et al (2003) Intracoronary stenting and angiographic results: strut thickness effect on restenosis outcome (ISAR-STEREO-2) trial. J Am Coll Cardiol 41:1283–1288. doi:10.​1016/​S0735-1097(03)00119-0 CrossRef
Zurück zum Zitat Peters D, Kastantin M, Kotamraju VK, Karmali PP, Gujraty K, Tirrell M, Ruoslahti E (2009) Targeting atherosclerosis by using modular, multifunctional micelles. Proc Natl Acad Sci USA 106:9815–9819. doi:10.1073/pnas.0903369106 Peters D, Kastantin M, Kotamraju VK, Karmali PP, Gujraty K, Tirrell M, Ruoslahti E (2009) Targeting atherosclerosis by using modular, multifunctional micelles. Proc Natl Acad Sci USA 106:9815–9819. doi:10.​1073/​pnas.​0903369106
Zurück zum Zitat Potineni A, Lynn DM, Langer R, Amiji MM (2003) Poly(ethylene oxide)-modified poly(b-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery. J Control Release 86:223–234. doi:10.1016/S0168-3659(02)00374-7 CrossRef Potineni A, Lynn DM, Langer R, Amiji MM (2003) Poly(ethylene oxide)-modified poly(b-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery. J Control Release 86:223–234. doi:10.​1016/​S0168-3659(02)00374-7 CrossRef
Zurück zum Zitat Schmehl J, Harder C, Hans P, Wendel H, Claus D, Claussen C, Tepe G (2008) Silicon carbide coating of nitinol stents to increase antithrombogenic properties and reduce nickel release. J Card Revasc Med 9:255–262. doi:10.1016/j.carrev.2008.03.004 CrossRef Schmehl J, Harder C, Hans P, Wendel H, Claus D, Claussen C, Tepe G (2008) Silicon carbide coating of nitinol stents to increase antithrombogenic properties and reduce nickel release. J Card Revasc Med 9:255–262. doi:10.​1016/​j.​carrev.​2008.​03.​004 CrossRef
Zurück zum Zitat Song CX, Labhasetwar V, Murphy H, Qu X, Humphrey WR, Shebuski RJ, Levy RJ (1997) Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery. J Control Release 43:197–212. doi:10.1016/S0168-3659(96)01484-8 CrossRef Song CX, Labhasetwar V, Murphy H, Qu X, Humphrey WR, Shebuski RJ, Levy RJ (1997) Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery. J Control Release 43:197–212. doi:10.​1016/​S0168-3659(96)01484-8 CrossRef
Zurück zum Zitat Southworth R, Kaneda M, Chen J, Zhang L, Zhang H, Yang X, et al (2009) Renal vascular inflammation induced by Western diet in ApoE-null mice quantified by 19F NMR of VCAM-1 targeted nanobeacons. Nanomedicine 5:359–367. doi:10.1016/j.nano.2008.12.002 Southworth R, Kaneda M, Chen J, Zhang L, Zhang H, Yang X, et al (2009) Renal vascular inflammation induced by Western diet in ApoE-null mice quantified by 19F NMR of VCAM-1 targeted nanobeacons. Nanomedicine 5:359–367. doi:10.​1016/​j.​nano.​2008.​12.​002
Zurück zum Zitat Stone G, Moses J, Ellis S, Schofer J, Dawkins K, Morice M, Colombo A et al (2007) Safety and efficacy of sirolimus and paclitaxel-eluting stents. J N Engl Med 356:998–1008. doi:10.1056/NEJMoa067193 CrossRef Stone G, Moses J, Ellis S, Schofer J, Dawkins K, Morice M, Colombo A et al (2007) Safety and efficacy of sirolimus and paclitaxel-eluting stents. J N Engl Med 356:998–1008. doi:10.​1056/​NEJMoa067193 CrossRef
Zurück zum Zitat Tang TY, Howarth SP, Miller SR, Graves MJ, Patterson AJ, et al (2009b) The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study. Evaluation using ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging in carotid disease. J Am Coll Cardiol 53:2039–50. doi:10.1016/j.jacc.2009.03.018 Tang TY, Howarth SP, Miller SR, Graves MJ, Patterson AJ, et al (2009b) The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study. Evaluation using ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging in carotid disease. J Am Coll Cardiol 53:2039–50. doi:10.​1016/​j.​jacc.​2009.​03.​018
Zurück zum Zitat Tassa C, Shaw SY, Weissleder R (2011) Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics and therapy. Acc Chem Res 44:842–852. doi:10.1021/ar200084x CrossRef Tassa C, Shaw SY, Weissleder R (2011) Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics and therapy. Acc Chem Res 44:842–852. doi:10.​1021/​ar200084x CrossRef
Zurück zum Zitat Tenzer S, Docter D, Rosfa S, Wlodarski A, Kuharev J, Rekik A, Knauer SK, Bantz C, Nawroth T, Bier C et al (2011) Nanoparticle size is a critical physicochemical determinant of the human blood plasma corona: a comprehensive quantitative proteomic analysis. ACS Nano 5:7155–7167. doi:10.1021/nn201950e CrossRef Tenzer S, Docter D, Rosfa S, Wlodarski A, Kuharev J, Rekik A, Knauer SK, Bantz C, Nawroth T, Bier C et al (2011) Nanoparticle size is a critical physicochemical determinant of the human blood plasma corona: a comprehensive quantitative proteomic analysis. ACS Nano 5:7155–7167. doi:10.​1021/​nn201950e CrossRef
Zurück zum Zitat Tong S, Hou S, Zheng Z, Zhou J, Bao G (2010) Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity. Nano Lett 10:4607–4613. doi:10.1021/nl102623x CrossRef Tong S, Hou S, Zheng Z, Zhou J, Bao G (2010) Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity. Nano Lett 10:4607–4613. doi:10.​1021/​nl102623x CrossRef
Zurück zum Zitat Vroman L, Adams AL, Fischer GC, Munoz PC (1980) Interaction of high molecular weight kininogen, factor XII, and fibrinogen in plasma at interfaces. Blood 55:156–159 Vroman L, Adams AL, Fischer GC, Munoz PC (1980) Interaction of high molecular weight kininogen, factor XII, and fibrinogen in plasma at interfaces. Blood 55:156–159
Zurück zum Zitat Winter PM, Caruthers SD, Kassner A et al (2003) Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel αvβ3 -targeted nanoparticle and 1.5 tesla magnetic resonance imaging. J Cancer Res 63:5838–5843 Winter PM, Caruthers SD, Kassner A et al (2003) Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel αvβ3 -targeted nanoparticle and 1.5 tesla magnetic resonance imaging. J Cancer Res 63:5838–5843
Zurück zum Zitat Yancy AD, Olzinski AR, Hu TC, Lenhard SC, Aravindhan K, Gruver SM, Jacobs PM, Willette RN, Jucker BM (2005) Differential uptake of ferumoxtran-10 and ferumoxytol, ultrasmall superparamagnetic iron oxide contrast agents in rabbit: critical determinants of atherosclerotic plaque labeling. J Magn Reson Imaging 21:432–442. doi:10.1002/jmri.20283 CrossRef Yancy AD, Olzinski AR, Hu TC, Lenhard SC, Aravindhan K, Gruver SM, Jacobs PM, Willette RN, Jucker BM (2005) Differential uptake of ferumoxtran-10 and ferumoxytol, ultrasmall superparamagnetic iron oxide contrast agents in rabbit: critical determinants of atherosclerotic plaque labeling. J Magn Reson Imaging 21:432–442. doi:10.​1002/​jmri.​20283 CrossRef
Metadaten
Titel
Nanomedicine highlights in atherosclerosis
verfasst von
Varvara Karagkiozaki
Publikationsdatum
01.04.2013
Verlag
Springer Netherlands
Erschienen in
Journal of Nanoparticle Research / Ausgabe 4/2013
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI
https://doi.org/10.1007/s11051-013-1529-1

Weitere Artikel der Ausgabe 4/2013

Journal of Nanoparticle Research 4/2013 Zur Ausgabe

    Marktübersichten

    Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen.