2014 | OriginalPaper | Buchkapitel
Need of Multimodal SPECT/MRI for Tracking of 111In-Labeled Human Mesenchymal Stem Cells in Neuroblastoma Tumor-Bearing Mice
verfasst von : L. Cussó, I. Mirones, S. Peña-Zalbidea, L. Lopez-Sánchez, V. García-Vázquez, J. García-Castro, M. Desco
Erschienen in: XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013
Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.
Wählen Sie Textabschnitte aus um mit Künstlicher Intelligenz passenden Patente zu finden. powered by
Markieren Sie Textabschnitte, um KI-gestützt weitere passende Inhalte zu finden. powered by
Tumor-homing is a complex, multistep process used by many cells, like mesenchymal stem cells (MSCs), to travel from a distant location to a tumor. The purpose of this study is to investigate the applicability of
111
In-oxine for tracking human MSCs in vivo with single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI).
111
In labeled hMSCs (10
6
cells) were infused intraperitoneally in neuroblastoma tumor-bearing mice, and SPECT/MRI images were performed 24 and 48 hour afterwards. High initial hMSC localization occurred in the abdomen cavity and 48 hour later hMSC-injected animals showed tumor uptake. MRI information was essential to properly define Regions of Interest on the images. Tracking
111
In labeled hMSC combining SPECT and MRI is feasible and may be transferable to human studies.