Skip to main content

2010 | OriginalPaper | Buchkapitel

11. Noninvasive Assessment of Left Ventricular Remodeling: Geometry, Wall Stress, and Function

verfasst von : Liang Zhong, Ru San Tan, Yi Su, Si Yong Yeo, Terrace Chua, Tian Hai Koh, Dhanjoo Ghista, Ghassan Kassab

Erschienen in: Computational Cardiovascular Mechanics

Verlag: Springer US

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Left ventricular (LV) remodeling after myocardial infarction (MI) plays an important role in the progression of heart failure (HF). Changes in the shape, size, and function of the LV are caused by altered mechanical properties of the injured myocardium. As the survival rate after MI improves with medical advances, the incidence of HF patients increases. Hence, an accurate depiction of the LV remodeling process facilitates disease surveillance and monitoring of therapeutic efficacy. It may also help determine the choice of treatment, e.g., surgery to remove the infarcted wall segment and reduce the LV cavity size. Traditionally, there are several ways of characterizing LV remodeling: changes in LV diameter, LV volume, ejection fraction, and qualitative or semi-quantitative descriptors of LV shape. In this chapter, we present a new approach to quantify LV shape (in terms of curvedness), wall stress, and function by using computational modeling.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Cohn JN, Ferrari R, Sharpe N. Cardiac remodeling – concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol. 2000;35:569–382.CrossRef Cohn JN, Ferrari R, Sharpe N. Cardiac remodeling – concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol. 2000;35:569–382.CrossRef
2.
Zurück zum Zitat Maron BJ. Distinguishing hypertrophic cardiomyopathy from athlete’s heart: a clinical problem of increasing magnitude and significance. Heart 2005;91(11):1380–82.CrossRef Maron BJ. Distinguishing hypertrophic cardiomyopathy from athlete’s heart: a clinical problem of increasing magnitude and significance. Heart 2005;91(11):1380–82.CrossRef
3.
Zurück zum Zitat Pfeffer JM, Pfeffer MA, Fletcher PJ, Braunwald E. Progressive ventricular remodeling rat with myocardialinfarction. Am J Physiol Heart Circ. 1991;260:H1406–14. Pfeffer JM, Pfeffer MA, Fletcher PJ, Braunwald E. Progressive ventricular remodeling rat with myocardialinfarction. Am J Physiol Heart Circ. 1991;260:H1406–14.
4.
Zurück zum Zitat Ganau A, Devereux RB, Roman MJ. Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension. J Am Coll Cardiol. 1992;19(7):1559–60.CrossRef Ganau A, Devereux RB, Roman MJ. Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension. J Am Coll Cardiol. 1992;19(7):1559–60.CrossRef
5.
Zurück zum Zitat Cohen MV, Yang XM, Neumann T. Favorable remodeling enhances recovery of regional myocardial function in the weeks after infarction in ischemically preconditioned hearts. Circulation. 2000;102:579–83.CrossRef Cohen MV, Yang XM, Neumann T. Favorable remodeling enhances recovery of regional myocardial function in the weeks after infarction in ischemically preconditioned hearts. Circulation. 2000;102:579–83.CrossRef
6.
Zurück zum Zitat Zhong L, Su Y, Yeo SY, Tan RS, Ghista DN, Kassab GS. Left ventricular regional wall curvedness and wall stress in patients with ischemic dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2009b;296(3):H573–84.CrossRef Zhong L, Su Y, Yeo SY, Tan RS, Ghista DN, Kassab GS. Left ventricular regional wall curvedness and wall stress in patients with ischemic dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2009b;296(3):H573–84.CrossRef
7.
Zurück zum Zitat Greenberg B, Quinones MA, Koilpillai C, Limacher M, Shindler D, Benedict C, Shelton B. Effects of long-term enalapril therapy on cardiac structure and function in patients with left ventricular dysfunction. Circulation. 1995;91:2573–81.CrossRef Greenberg B, Quinones MA, Koilpillai C, Limacher M, Shindler D, Benedict C, Shelton B. Effects of long-term enalapril therapy on cardiac structure and function in patients with left ventricular dysfunction. Circulation. 1995;91:2573–81.CrossRef
8.
Zurück zum Zitat The Digitalis Investigation Group. The effects of digoxin on morality and morbidity in patients with heart failure. N Engl J Med. 1997;336:525–33.CrossRef The Digitalis Investigation Group. The effects of digoxin on morality and morbidity in patients with heart failure. N Engl J Med. 1997;336:525–33.CrossRef
9.
Zurück zum Zitat Rubin SA, Fishbein MC, Swan HJC. Compensatory hypertrophy in the heart after myocardial infarction in the rat. J Am Coll Cardiol. 1983;61:1435–41.CrossRef Rubin SA, Fishbein MC, Swan HJC. Compensatory hypertrophy in the heart after myocardial infarction in the rat. J Am Coll Cardiol. 1983;61:1435–41.CrossRef
10.
Zurück zum Zitat Gaballa MA, Goldman S. Ventricular remodeling in heart failure. J Card Fail. 2002;8:S476–85.CrossRef Gaballa MA, Goldman S. Ventricular remodeling in heart failure. J Card Fail. 2002;8:S476–85.CrossRef
11.
Zurück zum Zitat Mitchell GF, Lamas GA, Vaughan DE, Pfeffer MA. Left ventricular remodeling in the year after first anterior myocardial infarction: a quantitative analysis of contractile segment lengths and ventricular shape. J Am Coll Cardiol. 1992;19:1136–44.CrossRef Mitchell GF, Lamas GA, Vaughan DE, Pfeffer MA. Left ventricular remodeling in the year after first anterior myocardial infarction: a quantitative analysis of contractile segment lengths and ventricular shape. J Am Coll Cardiol. 1992;19:1136–44.CrossRef
12.
Zurück zum Zitat Kono T, Sabbah HN, Steain PD, Brymer JF, Khaja F. Left ventricular shape as a determinant of mitral regurgitation in patients with several heart failures secondary to either coronary artery disease or idiopathic dilated cardiomyopathy. Am J Cardiol. 1991;68:355–9.CrossRef Kono T, Sabbah HN, Steain PD, Brymer JF, Khaja F. Left ventricular shape as a determinant of mitral regurgitation in patients with several heart failures secondary to either coronary artery disease or idiopathic dilated cardiomyopathy. Am J Cardiol. 1991;68:355–9.CrossRef
13.
Zurück zum Zitat Kass DA, Trail TA, Keating M, Altieri PI. Abnormalities of dynamic ventricular shape change in patients with aortic and mitral valvular regurgitation: assessment by Fourier shape analysis and global geometric indexes. Circ Res. 1988;62:127–38.CrossRef Kass DA, Trail TA, Keating M, Altieri PI. Abnormalities of dynamic ventricular shape change in patients with aortic and mitral valvular regurgitation: assessment by Fourier shape analysis and global geometric indexes. Circ Res. 1988;62:127–38.CrossRef
14.
Zurück zum Zitat Manici GB, DeBoe SF, Anselmo E, Simon SB. Quantitative regional curvature analysis: an application of shape determination of the assessment of segmental left ventricular function in man. Am Heart J. 1987;113:326–34.CrossRef Manici GB, DeBoe SF, Anselmo E, Simon SB. Quantitative regional curvature analysis: an application of shape determination of the assessment of segmental left ventricular function in man. Am Heart J. 1987;113:326–34.CrossRef
15.
Zurück zum Zitat Yeo SY, Zhong L, Su Y, Tan RS, Ghista DN. A curvature-based approach for left ventricular shape analysis from cardiac magnetic resonance imaging. Med Biol Eng Comput. 2009;47(3):313–22.CrossRef Yeo SY, Zhong L, Su Y, Tan RS, Ghista DN. A curvature-based approach for left ventricular shape analysis from cardiac magnetic resonance imaging. Med Biol Eng Comput. 2009;47(3):313–22.CrossRef
16.
Zurück zum Zitat Radhakrishnan S, Ghista DN, Jayaraman G. Mechanical analysis of the development of left ventricular aneurysms. J Biomech. 1980;13:1031–9.CrossRef Radhakrishnan S, Ghista DN, Jayaraman G. Mechanical analysis of the development of left ventricular aneurysms. J Biomech. 1980;13:1031–9.CrossRef
17.
Zurück zum Zitat Litwin SE, Litwin CM, Raya TE, Warner A, Goldman S. Contractility and stiffness of noninfarcted myocardium following coronary ligation in rats: effects of chronic angiotensin converting enzyme inhibition. Circulation. 1991;83:1028–37.CrossRef Litwin SE, Litwin CM, Raya TE, Warner A, Goldman S. Contractility and stiffness of noninfarcted myocardium following coronary ligation in rats: effects of chronic angiotensin converting enzyme inhibition. Circulation. 1991;83:1028–37.CrossRef
18.
Zurück zum Zitat Hirota Y, Shimizu G, Kaku K, Saito T, Kino M, Kawamura K. Mechanisms of compensation and decompensation in dilated cardiomyopathy. Am J Cardiol. 1984;54:1033–38.CrossRef Hirota Y, Shimizu G, Kaku K, Saito T, Kino M, Kawamura K. Mechanisms of compensation and decompensation in dilated cardiomyopathy. Am J Cardiol. 1984;54:1033–38.CrossRef
19.
Zurück zum Zitat Bing OH, Brooks WW, Conrad CH, Weinstein KB, Spadaro J, Padvany P. Myocardial mechanics of infarcted and hypertrophied non-infarcted myocardium following experimental coronary artery occlusion. In: International Erwin Riesch Symposium, 1983,pp. 235–44. Bing OH, Brooks WW, Conrad CH, Weinstein KB, Spadaro J, Padvany P. Myocardial mechanics of infarcted and hypertrophied non-infarcted myocardium following experimental coronary artery occlusion. In: International Erwin Riesch Symposium, 1983,pp. 235–44.
20.
Zurück zum Zitat Borrow KM, Neumann A, Marcus RH. Effects of simultaneous alterations in preload and afterload on measurements of left ventricular contractility in patients with dilated cardiomyopathy: comparisons of ejection phase, isovolumetric and end-systolic force–velocity indexes. J Am Coll Cardiol. 1992;20:787–95.CrossRef Borrow KM, Neumann A, Marcus RH. Effects of simultaneous alterations in preload and afterload on measurements of left ventricular contractility in patients with dilated cardiomyopathy: comparisons of ejection phase, isovolumetric and end-systolic force–velocity indexes. J Am Coll Cardiol. 1992;20:787–95.CrossRef
21.
Zurück zum Zitat Zile MR, Gaasch WH, Carroll JD. Chronic mitral regurgitation: predictive value of preoperative echocardiographic indexes of left ventricular function and wall stress. J Am Coll Cardiol. 1984;3:235–42.CrossRef Zile MR, Gaasch WH, Carroll JD. Chronic mitral regurgitation: predictive value of preoperative echocardiographic indexes of left ventricular function and wall stress. J Am Coll Cardiol. 1984;3:235–42.CrossRef
22.
Zurück zum Zitat Gunther S, Grossman W. Determinants of ventricular function in pressure-overload hypertrophy in man. Circulation. 1979;59:679–88.CrossRef Gunther S, Grossman W. Determinants of ventricular function in pressure-overload hypertrophy in man. Circulation. 1979;59:679–88.CrossRef
23.
Zurück zum Zitat Broughton A., Korner PI. Steady-state effects of preload and afterload on isovolumic indices of contractility in autonomically blocked dogs. Cardiovasc Res. 1980;14:245–53.CrossRef Broughton A., Korner PI. Steady-state effects of preload and afterload on isovolumic indices of contractility in autonomically blocked dogs. Cardiovasc Res. 1980;14:245–53.CrossRef
24.
Zurück zum Zitat Suga H, Sagawa K, Shoukas AA. Load independence of the instantaneous pressure–volume ratio of the canine left ventricular and effects of epinephrine and heart rate on the ratio. Circ Res. 1973;32:314–22.CrossRef Suga H, Sagawa K, Shoukas AA. Load independence of the instantaneous pressure–volume ratio of the canine left ventricular and effects of epinephrine and heart rate on the ratio. Circ Res. 1973;32:314–22.CrossRef
25.
Zurück zum Zitat Zhong L, Ghista DN, Ng EY, Lim ST. Passive and active ventricular elastances of the left ventricle. Biomed Eng Online. 2005;4(1):14.CrossRef Zhong L, Ghista DN, Ng EY, Lim ST. Passive and active ventricular elastances of the left ventricle. Biomed Eng Online. 2005;4(1):14.CrossRef
26.
Zurück zum Zitat Kass DA, Beyer R. Evaluation of contractile state by maximal ventricular power divided by the square of end-diastolic volume. Circulation. 1991;84:1698–708.CrossRef Kass DA, Beyer R. Evaluation of contractile state by maximal ventricular power divided by the square of end-diastolic volume. Circulation. 1991;84:1698–708.CrossRef
27.
Zurück zum Zitat Zhong L, Tan RS, Ghista DN, Ng EY, Chua LP, Kassab GS. Validation of a novel noninvasive cardiac index of left ventricular contractility in patients. Am J Physiol Heart Circ Physiol. 2007;292(6):H2764–72.CrossRef Zhong L, Tan RS, Ghista DN, Ng EY, Chua LP, Kassab GS. Validation of a novel noninvasive cardiac index of left ventricular contractility in patients. Am J Physiol Heart Circ Physiol. 2007;292(6):H2764–72.CrossRef
28.
Zurück zum Zitat Zhong L, Sola S, Tan RS, Ghista DN, Kurra V, Navia JL, Kassab GS. Effects of surgical ventricular restoration on left ventricular contractility assessed by a novel contractility index in patients with ischemic cardiomyopathy. Am J Cardiol. 2009a;103:674–79.CrossRef Zhong L, Sola S, Tan RS, Ghista DN, Kurra V, Navia JL, Kassab GS. Effects of surgical ventricular restoration on left ventricular contractility assessed by a novel contractility index in patients with ischemic cardiomyopathy. Am J Cardiol. 2009a;103:674–79.CrossRef
29.
Zurück zum Zitat Voigt JU, Lindenmeier G, Werner D, Flachskampf FA, Nixdorff U, Hatle L, Sutherland GR, Daniel WG. Strain rate imaging for the assessment of preload-dependent changes in regional left ventricular diastolic longitudinal function. J Am Soc Echocardiogr. 2002;15(1):13–19.CrossRef Voigt JU, Lindenmeier G, Werner D, Flachskampf FA, Nixdorff U, Hatle L, Sutherland GR, Daniel WG. Strain rate imaging for the assessment of preload-dependent changes in regional left ventricular diastolic longitudinal function. J Am Soc Echocardiogr. 2002;15(1):13–19.CrossRef
30.
Zurück zum Zitat Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM. Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm. J Thorac Cardiovasc Surg. 2005a;135:1094–102.CrossRef Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM. Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm. J Thorac Cardiovasc Surg. 2005a;135:1094–102.CrossRef
31.
Zurück zum Zitat Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM. MRI-based finite-element analysis of left ventricular aneurysm. Am J Physiol Heart Circ Physiol. 2005b;289:H692–700.CrossRef Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM. MRI-based finite-element analysis of left ventricular aneurysm. Am J Physiol Heart Circ Physiol. 2005b;289:H692–700.CrossRef
32.
33.
Zurück zum Zitat Jana R. Estimation of local myocardial stress. Am J Physiol Heart Circ Physiol. 1982;242:H875–81. Jana R. Estimation of local myocardial stress. Am J Physiol Heart Circ Physiol. 1982;242:H875–81.
34.
Zurück zum Zitat Beyar R, Shapiro E, Graves W, Guier W, Carey G, Soulen R, Zerhouni E, Weisfeldt M, Weiss J. Quantification and validation of left ventricular wall thickening by a three-dimensional element magnetic resonance imaging approach. Circulation. 1990;81:297–307.CrossRef Beyar R, Shapiro E, Graves W, Guier W, Carey G, Soulen R, Zerhouni E, Weisfeldt M, Weiss J. Quantification and validation of left ventricular wall thickening by a three-dimensional element magnetic resonance imaging approach. Circulation. 1990;81:297–307.CrossRef
35.
Zurück zum Zitat Linzbach AJ. Heart failure from the point of view of quantitative anatomy. Am J Cardiol. 1960;5:370–82.CrossRef Linzbach AJ. Heart failure from the point of view of quantitative anatomy. Am J Cardiol. 1960;5:370–82.CrossRef
36.
Zurück zum Zitat Pouleur H, Rousseau MF, van Eyll C, Meilin J, Youngblood M, Yusuf S. Cardiac mechanics during development of heart failure. SOLVD Investigators. Circulation. 1993;87:V14–20. Pouleur H, Rousseau MF, van Eyll C, Meilin J, Youngblood M, Yusuf S. Cardiac mechanics during development of heart failure. SOLVD Investigators. Circulation. 1993;87:V14–20.
37.
Zurück zum Zitat Shannon RP, Komamura K, Shen YT, Bishop SP, Vatner SF. Impaired regional subendocardial coronary flow reserve in conscious dogs with pacing-induced heart failure. Am J Physiol Heart Circ Physiol. 1993;265:H801–09. Shannon RP, Komamura K, Shen YT, Bishop SP, Vatner SF. Impaired regional subendocardial coronary flow reserve in conscious dogs with pacing-induced heart failure. Am J Physiol Heart Circ Physiol. 1993;265:H801–09.
38.
Zurück zum Zitat Drerup B, Hierholzer E. Objective determination of anatomical landmarks on the body surface: measurement of the vertebra prominens from surface curvature. J Biomech. 1985;18:467–74.CrossRef Drerup B, Hierholzer E. Objective determination of anatomical landmarks on the body surface: measurement of the vertebra prominens from surface curvature. J Biomech. 1985;18:467–74.CrossRef
39.
Zurück zum Zitat Liu X, Kim W, Drerup B, Mahadev A. Tibial torsion measurement by surface curvature. Clin Biomech. 2005;20:443–50.CrossRef Liu X, Kim W, Drerup B, Mahadev A. Tibial torsion measurement by surface curvature. Clin Biomech. 2005;20:443–50.CrossRef
40.
Zurück zum Zitat Willmore TJ. An introduction to differential geometry. Oxford University Press, Delhi, 1985. Willmore TJ. An introduction to differential geometry. Oxford University Press, Delhi, 1985.
41.
Zurück zum Zitat Koenderink JJ, van Doom AJ. Surface shape and curvature scales. Image Vis Comput. 1992;10:557–65.CrossRef Koenderink JJ, van Doom AJ. Surface shape and curvature scales. Image Vis Comput. 1992;10:557–65.CrossRef
42.
Zurück zum Zitat Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professional from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002;105:539–42.CrossRef Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professional from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002;105:539–42.CrossRef
43.
Zurück zum Zitat Grossman W, Braunwald E, Mann T, McLaurin L, Green L. Contractile state of the left ventricle in man as evaluated from end-systolic pressure–volume relations. Circulation. 1977;56:845–52.CrossRef Grossman W, Braunwald E, Mann T, McLaurin L, Green L. Contractile state of the left ventricle in man as evaluated from end-systolic pressure–volume relations. Circulation. 1977;56:845–52.CrossRef
44.
Zurück zum Zitat Reichek N, Wilson J, St. John Sutton M, Plappert, TA, Goldberg S, Hirshfeld JW. Noninvasive determination of left ventricular end-systolic stress: validation of the method and initial application. Circulation. 1982;65:99–108.CrossRef Reichek N, Wilson J, St. John Sutton M, Plappert, TA, Goldberg S, Hirshfeld JW. Noninvasive determination of left ventricular end-systolic stress: validation of the method and initial application. Circulation. 1982;65:99–108.CrossRef
45.
Zurück zum Zitat Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Hsu EW, Saloner DA, Guccione JM. Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm. J Thorac Cardiovasc Surg. 2008;35:1094–1102.CrossRef Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Hsu EW, Saloner DA, Guccione JM. Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm. J Thorac Cardiovasc Surg. 2008;35:1094–1102.CrossRef
Metadaten
Titel
Noninvasive Assessment of Left Ventricular Remodeling: Geometry, Wall Stress, and Function
verfasst von
Liang Zhong
Ru San Tan
Yi Su
Si Yong Yeo
Terrace Chua
Tian Hai Koh
Dhanjoo Ghista
Ghassan Kassab
Copyright-Jahr
2010
Verlag
Springer US
DOI
https://doi.org/10.1007/978-1-4419-0730-1_11

Neuer Inhalt