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Journal of Polymer Research

Erschienen in:

01.11.2017 | ORIGINAL PAPER

Novel hybrid block copolymer nanocarrier systems to load lipophilic drugs prepared by microphase inversion method

verfasst von: Andrea Granada, Issei Otsuka, Thiago Caon, Marcos Antonio Segatto Silva, Valdir Soldi, Redouane Borsali

Erschienen in: Journal of Polymer Research | Ausgabe 12/2017

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Abstract

Nanoparticles based on block copolymers of oligosaccharides [β-cyclodextrin (βCyD) and maltoheptaose (Mal₇)] and poly(ε-caprolactone) (PCL) were prepared by microphase inversion method. Zeta-potential, particle size measurements and morphological analysis of drug-free and drug-loaded nanoparticles were performed by using, respectively, laser-doppler anemometry, dynamic and static light scattering and transmission electron microscopy. ρ-Ratio values were correlated with transmission electron microscopy observations. Both types of amphiphilic block copolymers, βCyD-b-PCL_5k and Mal₇-b-PCL_5k, self-assembled in water to form spherical vesicles, presented a hydrodynamic diameter of 72 and 34 nm, respectively. The incorporation of drugs into nanoparticles did not affect significantly the particle size for βCyD-b-PCL_5k-based nanoparticles with progesterone, unlike the other tested systems. On the other hand, all nanoparticles (with and without drug) were negatively charged. Both nanoparticulate systems showed high drug loading efficiency (higher than 95%), confirming their suitability as delivery system for lipophilic drugs.

Vorheriger Artikel Exploring the roles of molecular structure on the β-crystallization of polypropylene random copolymer

Nächster Artikel Preparation and enhanced mechanical properties of hydroxyapatite hybrid hydrogels via novel photocatalytic polymerization

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Titel: Novel hybrid block copolymer nanocarrier systems to load lipophilic drugs prepared by microphase inversion method
verfasst von: Andrea Granada
Issei Otsuka
Thiago Caon
Marcos Antonio Segatto Silva
Valdir Soldi
Redouane Borsali
Publikationsdatum: 01.11.2017
Verlag: Springer Netherlands
Erschienen in: Journal of Polymer Research / Ausgabe 12/2017
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI: https://doi.org/10.1007/s10965-017-1351-z

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