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2014 | Buch

A Brief Introduction to Optical Nanoprobes Kapitel lesen Erstes Kapitel lesen

Novel Optical Nanoprobes for Chemical and Biological Analysis

verfasst von: Lingxin Chen, Yunqing Wang, Xiuli Fu, Ling Chen

Verlag: Springer Berlin Heidelberg

Buchreihe : SpringerBriefs in Molecular Science

Enthalten in: Springer Professional "Wirtschaft+Technik" , Springer Professional "Technik"

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SUCHEN

Über dieses Buch

Novel Optical Nanoprobes for Chemical and Biological Analysis starts with a brief introduction to several kinds of versatile nanomaterials with novel optical properties, such as gold/silver nanoparticles, quantum dots, upconversion nanoparticles and graphene. It mainly focuses on the latest sensor design strategies, which apply the optical properties of nanomaterials to various detection techniques including colorimetry, fluorescence, and surface-enhanced Raman scattering (SERS). These sensors are attractive owing to their high sensitivity, high specificity, and potential for easy quantification of targets in many applications, such as conventional chemical and biological analysis, clinical diagnosis, and intracellular system sensing as well as single-molecule detection. The challenges and future perspectives for optical nanoprobes are also presented, such as the increase in sensitivity for real environmental and clinical samples, the design and application of multifunctional nanoplatforms, and biocompatibility of nanomaterials.

Inhaltsverzeichnis

Frontmatter
Chapter 1. A Brief Introduction to Optical Nanoprobes
Abstract
Nanomaterial-based novel optical nanoprobes have been extensively developed because of their high sensitivity, high specificity, and potential for easy quantification of species in chemical and biological analysis. With the development of nanotechnology, various kinds of nanomaterials with novel optical properties have been generated, laying the foundation of optical nanoprobes. By further integrating receptors (chemical ligand, aptamer, molecular imprinting polymer, etc.), the chemical information of binding specific targets will transform into analytically useful optical variation signals, employing different detection techniques including colorimetry/UV–Vis spectra, fluorometry and surface enhanced Raman scatting. In this chapter, a brief introduction of optical nanoprobes is given in terms of nanomaterials, recognition units, and optical detection.
Lingxin Chen, Yunqing Wang, Xiuli Fu, Ling Chen
Chapter 2. Colorimetric Nanoprobes
Abstract
The development of highly sensitive, cost-effective, miniature nanoparticle-based colorimetric nanoprobes attracted great attention in recent years. Depending on their excellent performance in environmental and biological analysis, colorimetric nanoprobes have been widely used for sensing a wide range of analytes/targets, such as metallic cations, anions, small organic molecules, oligonucleotides, proteins, cancer cells, etc. In this chapter, we first introduce the optical absorption properties of nanomaterial, mainly focusing on the noble metal nanomaterials, such as sphere gold nanoparticles, gold nanorods, and silver nanoparticles. Then we discuss the colorimetric sensing strategies for ions, small molecules, oligonucleotides, and protein detection and cellular analysis, highlighting some of their technical challenges and the new trends by means of a set of selected recent applications.
Lingxin Chen, Yunqing Wang, Xiuli Fu, Ling Chen
Chapter 3. Fluorescent Nanoprobes
Abstract
With the development of nanotechnology, nanomaterials-based fluorescence sensors have been successfully fabricated for various applications. These nanomaterials include quantum dots, noble metal nanoclusters, upconversion nanoparticles, carbon nanostructures, and so on. In this chapter, the overviews of the fluorescence properties of nanomaterials, fluorescence sensing strategies, as well as their applications in biological and chemical sensing are given in detail.
Lingxin Chen, Yunqing Wang, Xiuli Fu, Ling Chen
Chapter 4. Surface-Enhanced Raman Scattering Nanoprobes
Abstract
During the last decade, novel nanoprobes named surface-enhanced Raman scattering (SERS) nanoprobes have drawn much attention of chemists. SERS nanoprobes produce strong, characteristic Raman signals, demonstrating optical labeling capability similar to those of commonly reported organic dyes and fluorescent quantum dots. However, this new generation of optical nanoprobes has the ultra-sensitivity, multiplexing, and quantitative abilities of the SERS technique, and shows extraordinary features for bioanalysis. In this chapter, we focus on the most recent advances of SERS nanoprobes. A brief overview of the basic concept and the synthesis of SERS nanoprobes is given. Also we discuss the nanoprobes’ growing popularity for bioanalysis at different levels of molecular multiplex detection, for bacterial and live-cell sensing, and for in vivo imaging from the aspect of different sensing mechanisms.
Lingxin Chen, Yunqing Wang, Xiuli Fu, Ling Chen
Chapter 5. Challenges and Perspectives of Optical Nanoprobes
Abstract
In recent years, the design of optical nanoprobes has achieved dramatic advances and certain nanosensors have been successfully applied to biological analysis and imaging. Still, challenges of optical nanoprobes also remain, such as increasing sensing performance for real environmental and clinical samples, the design and application of multifunctional nanoplatforms, and biocompatibility research.
Lingxin Chen, Yunqing Wang, Xiuli Fu, Ling Chen
Metadaten
Titel
Novel Optical Nanoprobes for Chemical and Biological Analysis
verfasst von
Lingxin Chen
Yunqing Wang
Xiuli Fu
Ling Chen
Copyright-Jahr
2014
Verlag
Springer Berlin Heidelberg
Electronic ISBN
978-3-662-43624-0
Print ISBN
978-3-662-43623-3
DOI
https://doi.org/10.1007/978-3-662-43624-0

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