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Acta Mechanica Sinica
Erschienen in: Acta Mechanica Sinica 2/2019

22.02.2019 | Review Paper

Nuclear mechanics during and after constricted migration

verfasst von: Yuntao Xia, Charlotte R. Pfeifer, Dennis E. Discher

Erschienen in: Acta Mechanica Sinica | Ausgabe 2/2019

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Abstract

Cell migration through very narrow spaces in tissues has been seen in both physiological and pathological contexts. For example, immune cells squeeze through the vasculature and the extracellular matrix to reach wound or disease sites, and similarly, cancer cells crawl through interstices in tissues to invade tumor-free regions. The bulky and stiff nucleus of a cell is a barrier to such constricted migration—with smaller pores exponentially more difficult for passage. Cells must actively deform their nuclei to squeeze through constrictions, and this involves the stress-generating cytoskeleton. Here we review: (1) nuclear structures and morphological regulation, (2) proposed mechanisms that drive constricted migration, (3) short-term consequences such as nuclear envelope (NE) rupture and DNA damage during such process, (4) biophysical factors that facilitate NE rupture, and (5) long-term consequences such as genomic variation caused by repetitive NE rupture. Both experimental results and modeling are provided with the intention to better understand constricted migration.
Vorheriger Artikel Mechanical microenvironment as a key cellular regulator in the liver
Nächster Artikel Effects of hypoxia on the biological behavior of MSCs seeded in demineralized bone scaffolds with different stiffness

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Metadaten
Titel
Nuclear mechanics during and after constricted migration
verfasst von
Yuntao Xia
Charlotte R. Pfeifer
Dennis E. Discher
Publikationsdatum
22.02.2019
Verlag
The Chinese Society of Theoretical and Applied Mechanics; Institute of Mechanics, Chinese Academy of Sciences
Erschienen in
Acta Mechanica Sinica / Ausgabe 2/2019
Print ISSN: 0567-7718
Elektronische ISSN: 1614-3116
DOI
https://doi.org/10.1007/s10409-018-00836-9

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