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Erschienen in:
2015 | OriginalPaper | Buchkapitel
Nucleation Kinetics of Carbamazepine-Saccharin (CBZ-SAC) Co-crystal
verfasst von : Khairool Azizul Mohammad, Syarifah Abd Rahim, Mohd Rushdi Abu Bakar
Erschienen in: ICGSCE 2014
Verlag: Springer Singapore
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Abstract
In this study the effect of the heating/cooling rate of various CBZ-SAC mixture in ethanol was investigated in order to deduce the metastable zone width (MSZW) and the nucleation order. Nývlt’s equation involving the maximum temperature difference \(\varDelta T_{ \hbox{max} }\) between dissolution and crystallization temperatures of CBZ-SAC co-crystals with the heating/cooling rate r was applied for the study of nucleation kinetics by the polythermal method. A step towards the determination of dissolution temperature of the crystals has been improved. The results showed that dissolution temperature for CBZ-SAC co-crystal mixture increased with the increase in heating rate, CBZ-concentration and the ratio of SAC to CBZ in ethanol solution. The analysis revealed that a nucleation order for CBZ-SAC co-crystals increases with the SAC to CBZ ratio and is in the range of 1.58–6.31.