The objective of the present work was to obtain chemopreventive compounds that can trap direct-acting carcinogens within the lumen of the gastrointestinal tract and thus prevent these carcinogens from attacking tissues of the host. Many direct-acting carcinogens are electrophiles (19, 36). One possible strategy for blocking their action is by trapping them with nucleophiles (electron donors). In the studies to be presented, emphasis has been placed on trapping direct-acting carcinogens in two sites, i.e., the stomach and the large intestine. To some extent different considerations pertain for each.
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- Nucleophiles as Anticarcinogens
Lee W. Wattenberg
J. Bradley Hochalter
Usha D. G. Prabhu
Arthur R. Galbraith
- Springer US