In this paper we rule out output polynomial listing algorithms for the general problem of discovering theories for a conjunction of monotone and anti-monotone constraints as well as for the particular subproblem in which all constraints are frequency-based. For the general problem we prove a concrete exponential lower time bound that holds for any correct algorithm and even in cases in which the size of the theory as well as the only previous bound are constant. For the case of frequency-based constraints our result holds unless
P = NP
. These findings motivate further research to identify tractable subproblems and justify approaches with exponential worst case complexity.